(R)-1-Boc-3-Hydroxypiperidine

Product Name: (R)-1-Boc-3-Hydroxypiperidine
CAS No.: 143900-43-0
Chemical Name: (R)-1-Boc-3-Hydroxypiperidine
Synonyms: (R)-1-N-BOC-3-HYDROXYPIPERIDINE;tert-Butyl (3R)-3-hydroxypiperidine-1-carboxylate;Ibrutinib INT2;Peridine Impurity 2;(R)-1-BOC-3-PIPERIDINOL;(R)-N-BOC-3-HYDROXYPIPERIDINE;(R)-1-BOC-3-HYDROXYPIPERIDINE;(R)-1-Boc-3-hydroxypiperidine,97%;(R)-1-Boc-3-hydroxypiperidine 95%;(R)-1-Boc-3-hydroxypiperidine
CBNumber: CB3125016
Molecular Formula: C10H19NO3
Formula Weight: 201.26
MOL File: 143900-43-0.mol

More

Less

(R)-1-Boc-3-Hydroxypiperidine Property

Melting point:: 43-50 °C
Boiling point:: 292.3±33.0 °C(Predicted)
Density: 1.107±0.06 g/cm3(Predicted)
Flash point:: 104°C
storage temp.: 2-8°C
solubility: soluble in Methanol
pka: 14.74±0.20(Predicted)
form: Low Melting Solid
color: White to tan
optical activity: [α]/D 22±3°, c = 5 in methanol
InChI: InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m1/s1
InChIKey: UIJXHKXIOCDSEB-MRVPVSSYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@@H](O)C1
CAS DataBase Reference: 143900-43-0(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: T
Risk Statements: 36/37/38-41-37/38-25
Safety Statements: 26-36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 29333990
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 687278
Product name: (R)-1-Boc-3-hydroxypiperidine
Purity: 95%
Packaging: 1g
Price: $88.33
Updated: 2025/07/31

TCI Chemical

Product number: B4199
Product name: (R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
Purity: >98.0%(GC)
Packaging: 1g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: B4199
Product name: (R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $100
Updated: 2025/07/31

TRC

Product number: B656655
Product name: (R)-1-Boc-3-hydroxypiperidine
Packaging: 2.5g
Price: $110
Updated: 2021/12/16

TRC

Product number: B656655
Product name: (R)-1-Boc-3-hydroxypiperidine
Packaging: 25g
Price: $695
Updated: 2021/12/16

More

Less

(R)-1-Boc-3-Hydroxypiperidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

(R)-1-Boc-3-hydroxypiperidine has been used as a reactant for the synthesis of piperidinyl and pyrrolidinyl butyrates. It has also been used for the synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.

Synthesis

A suspension of (3R)-piperidin-3-ol hydrochloride (3.17 g, 0.023 mol) in CH2Cl2 (40 mL) was treated with Na2CO3 (5.13 g, 0) dissolved in H2O (80 mL) 0.048 mol) and then treated with diiron dicarbonate/fluorobutyl ester (5.53 g, 0.025 mol) and additional CH2Cl3 (24 mL). The resulting mixture was stirred for 21 hours. The layers were separated and the aqueous phase was extracted with CH2Cl2 (3x50) mL) to extract the aqueous phase. The combined organic layers were dried with Na2SO4, filtered, and concentrated in vacuo. The residue was analyzed by column chromatography (9:1 CH2Cl2:MeOH) purification to give colorless oily (R)-1-Boc-3-hydroxypiperidine (5.07 g, quantitative). Mass spectrum (M+1): 202.0. 1H NMR (400 MHz, chloroform-D) ??ppm of 1.40-1.56 (M, 2h), 1.44 (s, 9h), 1.67-1.80 (M, 1H), 1.80-1.93 (M, 1 H), 2.95-3.22 (M, 2h), 3.47 (D, J=5.1 Hz, 1H), 3.51 (brs, 1H) and 3.64-3.78 (M, 2 H).

(R)-1-Boc-3-Hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(R)-1-Boc-3-Hydroxypiperidine Suppliers

Americas 1 China 224 Europe 3 Germany 4 India 12 Japan 3 Switzerland 1 United Kingdom 12 United States 46 Global 306

Sichuan Argalbio Technology Co,.Ltd

Tel: 028-028-60651388 13330964498
Email: slyu@hengkangtech.com
Country: China
ProdList: 475
Advantage: 58

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 11777
Advantage: 60

More

Less

View Lastest Price from (R)-1-Boc-3-Hydroxypiperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-1-Boc-3-Hydroxypiperidine 143900-43-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Shanghai UCHEM Inc.

Product: (R)-1-Boc-3-Hydroxypiperidine 143900-43-0
Price: US $63.00-308.00/g
Min. Order: 100g
Purity: 0.99
Supply Ability: 25kg
Release date: 2023-12-15

Henan Bao Enluo International TradeCo.，LTD

Product: (R)-1-Boc-3-Hydroxypiperidine 143900-43-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500t/month
Release date: 2023-08-17

143900-43-0, (R)-1-Boc-3-HydroxypiperidineRelated Search:

RESMETHRIN tert-Butanol tert-Butyl peroxyacetate Diethylene glycol monobutyl ether 3-Hydroxypiperidine 2-Butoxyethanol Lithium tri-tert-butoxyaluminum hydride Butyl acetate Buprofezin tert-Butyl acetate Haloperidol Cyhalofop-butyl (S)-1-BOC-3-HYDROXYPIPERIDINE Butyl acrylate (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)propan-1-one Ibrutinib (R)-tert-Butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate (S)-Ibrutinib

(R)-1-Boc-3-hydroxypiperidine 95%

tert-Butyl (3R)-3-hydroxypiperidine-1-carboxylate, (3R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine

tert- butyl (R)-3-hydroxy piperidine-1-carboxylate

(R)-1-Boc-3-hydroxypiperidine,97%

(R)-1-N-BOC-3-HYDROXYPIPERIDINE

(R)-1-BOC-3-PIPERIDINOL

(R)-1-BOC-3-HYDROXYPIPERIDINE

R-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE

(R)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-N-BOC-3-HYDROXYPIPERIDINE

(R)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE

(R)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE

Ibrutinib INT2

(R)-1-TERT-BUTOXYCARBONYL-3-AMINOPIPERIDINE

1-PIPERIDINECARBOXYLIC ACID, 3-HYDROXY-, 1,1-DIMETHYLETHYL ESTER, (3R)-

(R)-3-Hydroxypiperidine, N-BOC protected

(3R)-3-Hydroxypiperidine, N-BOC protected

tert-Butyl (3R)-3-hydroxypiperidine-1-carboxylate

(R)-tert-butyl 3-hydroxypiperidin-1-carboxylate

(R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine

(3R)-hydroxy-1-piperidinecarboxylic acid 1,1-diMethylethyl ester

(r)-3-hydroxy-piperidine-1-carboxylic acid tert-but

(R)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine &gt

(R)-1-Boc-3-Hydroxypiperidine ISO 9001：2015 REACH

1,1-Dimethylethyl (3R)-3-hydroxy-1-piperidinecarboxylate

tert-Butyl (3R)-3-hydroxy-1-piperidinecarboxylate

Peridine Impurity 2

(<i>R</i>)-1-Boc-3-hydroxypiperidine

143900-43-0

143900-43-00

143900-41-0

New Products for Chemical Synthesis May/June 2007

Ibrutinib intermediate

Piperazine

Piperidines

Piperidine