(S)-1-Boc-3-hydroxypiperidine
Uses- Product Name
- (S)-1-Boc-3-hydroxypiperidine
- CAS No.
- 143900-44-1
- Chemical Name
- (S)-1-Boc-3-hydroxypiperidine
- Synonyms
- tert-butyl (S)-3-hydroxypiperidine-1-carboxylate;(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;Ibrutinib Interm 0441;1,1-DiMethylethy;(S)-BOC-piperidinol;Ilutinib impurity 7;(S)-1-BOC-3-PIPERIDINOL;（S）-N-BOC-3-piperidinol;(S)-1-BOC-Piperidin-3-ol;(S)-1-Boc-3-Hdroxypiperidine
- CBNumber
- CB6197360
- Molecular Formula
- C10H19NO3
- Formula Weight
- 201.26
- MOL File
- 143900-44-1.mol
(S)-1-Boc-3-hydroxypiperidine Property
- Melting point:
- 34-40 °C
- Boiling point:
- 292.3±33.0 °C(Predicted)
- Density
- 1.107±0.06 g/cm3(Predicted)
- Flash point:
- 110 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Soluble in methanol.
- pka
- 14.74±0.20(Predicted)
- form
- Powder or Crystalline Powder
- color
- White to tan
- optical activity
- [α]22/D +10.0°, c = 1 in chloroform
- InChI
- InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1
- InChIKey
- UIJXHKXIOCDSEB-QMMMGPOBSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC[C@H](O)C1
- CAS DataBase Reference
- 143900-44-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 687367
- Product name
- (S)-1-Boc-3-hydroxypiperidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $112
- Updated
- 2024/03/01
- Product number
- B4446
- Product name
- (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $21
- Updated
- 2024/03/01
- Product number
- B4446
- Product name
- (S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $64
- Updated
- 2024/03/01
- Product number
- H52771
- Product name
- (S)-1-Boc-3-hydroxypiperidine, 97%
- Packaging
- 1g
- Price
- $50.65
- Updated
- 2024/03/01
- Product number
- H52771
- Product name
- (S)-1-Boc-3-hydroxypiperidine, 97%
- Packaging
- 5g
- Price
- $207.65
- Updated
- 2024/03/01
(S)-1-Boc-3-hydroxypiperidine Chemical Properties,Usage,Production
Uses
(S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.
Description
(S)-1-Boc-3-hydroxypiperidine, alias (S)-N-Boc-3-hydroxypiperidine (S-NBHP) is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies.S-NBHP can be prepared in a variety of ways such as chemically or biocatalytically. S-NBHP can be prepared in various ways, such as chemical synthesis or biocatalysis. Biocatalysis is an efficient process for the reduction of N-Boc-piperidin-3-one by recombinant keto reductase (KRED) catalytic to obtain optically pure S-NBHP using 99% yield. The asymmetric reduction of N-Boc-piperidin-3-one (NBPO) to (S)-NBHP can also be catalysed by a reductase (YDR541C) isolated from Saccharomyces cerevisiae in 99% yield.
Chemical Properties
White powder
Uses
(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate.
Uses
A piperidine derivative with an amine protecting group, (S)-1-Boc-3-hydroxypiperidine can be used in the preparation of biologically active compounds such as antagonists of the human P2X7 receptor and selective irreversible inhibitors for bruton's tyrosine kinase.
(S)-1-Boc-3-hydroxypiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-1-Boc-3-hydroxypiperidine Suppliers
View Lastest Price from (S)-1-Boc-3-hydroxypiperidine manufacturers
- Product
- (S)-1-Boc-3-hydroxypiperidine 143900-44-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-28
- Product
- (S)-1-Boc-3-hydroxypiperidine 143900-44-1
- Price
- US $63.00-308.00/g
- Min. Order
- 100g
- Purity
- 0.99
- Supply Ability
- 100kg
- Release date
- 2023-10-26
- Product
- (S)-1-BOC-3-hydroxypiperidine 143900-44-1
- Price
- US $90.00-80.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000kgs
- Release date
- 2023-08-02