D-Tryptophan methyl ester hydrochloride

Product Name: D-Tryptophan methyl ester hydrochloride
CAS No.: 14907-27-8
Chemical Name: D-Tryptophan methyl ester hydrochloride
Synonyms: D-TRYPTOPHAN METHYL ESTER HCL;Methyl D-Tryptophanate Hydrochloride;Trp-OMe;D-TRYPTOPHAN METHYL ESTER;ANAM-002;D-TRP.OME.HCL;D-Trp-OCH3.Hcl;H-D-TRP-OME·HCL;H-D-TRP-OME HCL;D-Tryptophan methyl
CBNumber: CB9459476
Molecular Formula: C12H15ClN2O2
Formula Weight: 254.71
MOL File: 14907-27-8.mol

More

Less

D-Tryptophan methyl ester hydrochloride Property

Melting point:: 213-216 °C(lit.)
Density: 1.337g/cm3 at 20℃
refractive index: -19 ° (C=5, MeOH)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
optical activity: [α]20/D 18°, c = 5 in methanol
Water Solubility: Soluble in water (150 mg/ml), dimethyl sulfoxide and methanol (50 mg/ml).
InChI: InChI=1/C12H14N2O2.ClH/c1-16-12(15)10(13)6-8-7-14-11-5-3-2-4-9(8)11;/h2-5,7,10,14H,6,13H2,1H3;1H/t10-;/s3
InChIKey: XNFNGGQRDXFYMM-MEQOOBBNNA-N
SMILES: C12C=CC=CC=1NC=C2C[C@@H](N)C(=O)OC.Cl |&1:10,r|
LogP: 1.089
CAS DataBase Reference: 14907-27-8(CAS DataBase Reference)

More

Less

Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PH017490
Product name: Methyl (2R)-2-amino-3-(1H-indol-3-yl)propanoate
Purity: AldrichCPR
Packaging: 1g
Price: $81.6
Updated: 2023/06/20

Sigma-Aldrich

Product number: 364509
Product name: D-Tryptophan methyl ester hydrochloride
Purity: 98%
Packaging: 5g
Price: $42.1
Updated: 2022/05/15

TCI Chemical

Product number: T2442
Product name: D-Tryptophan Methyl Ester Hydrochloride
Purity: >98.0%(N)
Packaging: 5g
Price: $25
Updated: 2024/03/01

TCI Chemical

Product number: T2442
Product name: D-Tryptophan Methyl Ester Hydrochloride
Purity: >98.0%(N)
Packaging: 25g
Price: $100
Updated: 2024/03/01

Alfa Aesar

Product number: H60622
Product name: D-Tryptophan methyl ester hydrochloride, 98%
Packaging: 5g
Price: $79.5
Updated: 2024/03/01

More

Less

D-Tryptophan methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Crystalline Solid

Uses

Intermediate for the synthesis of Tryptophan derivatives.

Uses

D-Tryptophan Methyl Ester Hydrochloride is an intermediate in the synthesis of Tryptophan derivatives.

Application

The Pictet–Spengler reaction of D-Tryptophan methyl ester hydrochloride with piperonal in various solvents has been extensively studied, the solvent-dependence of stereoselectivities could be principally attributed to the solubility difference between cis and trans products 5-HCl in the used solvent, the best stereoselectivity (cis/trans = 99:1) was obtained using nitromethane or acetonitrile as the solvent. Cialis, 12a-epi-Cialis, deuterium-labeled, 3,3,12a-d3-Cialis, and 3,3,12a-d3-12a-epi-Cialis could be efficiently synthesized from D-Tryptophan methyl ester hydrochloride[1].

Synthesis

D-tryptophan and methyl sulfonate are reacted in a solvent at 25 to 100°C to generate D-tryptophan methyl ester sulfonate. Dissolve the obtained D-tryptophan methyl ester sulfonate in water and adjust the pH to alkaline with alkali to convert it into D-tryptophan methyl ester. After the reaction, extract with an organic solvent, add a desiccant for dehydration, and obtain an extract containing D-tryptophan methyl ester. Finally, dry hydrogen chloride gas is passed into the obtained extract containing D-tryptophan methyl ester for reaction to obtain D-tryptophan methyl ester hydrochloride.

References

[1] Xiao-Xin Shi. “Highly stereoselective Pictet–Spengler reaction of d-tryptophan methyl ester with piperonal: convenient syntheses of Cialis (Tadalafil), 12a-epi-Cialis, and their deuterated analogues.” Tetrahedron, asymmetry 19 4 (2008): Pages 435-442.

D-Tryptophan methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

D-Tryptophan methyl ester hydrochloride Suppliers

Canada 1 China 441 Europe 2 France 1 Germany 4 India 20 Japan 2 South Korea 1 Switzerland 3 United Kingdom 9 United States 42 Global 526

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696;
Email: info@hanhongsci.com
Country: China
ProdList: 42982
Advantage: 64

Nanjing Redwood Fine Chemical Co., Ltd.

Tel: 400-8464006 15805183379
Fax: 86-025-58905816
Email: zjp@redwood.com.cn
Country: China
ProdList: 645
Advantage: 60

Nantong puyue biomedical Co., Ltd

Tel: 051389158300 18014392889
Fax: 0513-89158198
Email: sales8@puyerbiopharma.com
Country: China
ProdList: 4316
Advantage: 58

Sichuan Tongsheng Amino acids Co.,Ltd.

Tel: 0838-2809458 13350585791
Fax: +86-838-2274207
Email: pharm@biots.cn
Country: China
ProdList: 348
Advantage: 66

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10287
Advantage: 55

Shandong Mopai Biotechnology Co., Ltd

Tel: 13053322091 13053322091
Email: admin@mopaikeji.com
Country: China
ProdList: 10968
Advantage: 58

SuZhou Yumed Pharmaceutical Technology Co.,Ltd

Tel: 199-4188-3835 19941883835
Email: 746524151@qq.com
Country: China
ProdList: 53
Advantage: 58

Jinan Duowei Innovation Biotechnology Co., Ltd

Tel: 0531-58595315 13864187945
Email: 415834789@qq.com
Country: China
ProdList: 93
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

More

Less

View Lastest Price from D-Tryptophan methyl ester hydrochloride manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: D-Tryptophan methyl ester hydrochloride 14907-27-8
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99
Supply Ability: 20tons
Release date: 2024-02-06

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: D-Tryptophan methyl ester HCL 14907-27-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98+
Supply Ability: 1T
Release date: 2024-04-08

Zibo Hangyu Biotechnology Development Co., Ltd

Product: D-Tryptophan methyl ester hydrochloride 14907-27-8
Price: US $75.00-750.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-10-20

14907-27-8, D-Tryptophan methyl ester hydrochlorideRelated Search:

Tribenuron methyl METSULFURON METHYL Methyl acrylate D(+)-Tryptophan L-5-Hydroxytryptophan Methyl salicylate L-Alanine methyl ester hydrochloride L-Tryptophan Propionic acid Topotecan hydrochloride Thiophanate-methyl Kresoxim-methyl Methyl H-D-TRP-OBZL HCL H-D-TRP-OET HCL 7-METHOXY-D-TRYPTOPHAN 5-Methyl-D-tryptophan 5-BROMO-D-TRYPTOPHAN

(R)-Tryptophan Methyl Ester Monohydrochloride

Methyl D-Tryptophanate Hydrochloride

H-D-TRP-OME·HCL

D-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE 99%

D-TRP.OME.HCL

(S)-2-Amino-3-(1H-indol-3-yl)-propionic acid methyl ester hydrochloride

Methyl (2R)-2-amino-3-(1H-indol-3-yl)propanoate hydrochloride

D-Tryptophane methyl ester hydrochloride

Trp-OMe

Tryptophan Impurity 38

Tadalafil Intermediate 1

D-Tryptophan methyl ester·hydrochloride salt (H-D-Trp-OMe·HCl)

D-Tryptophan methyl

H-D-Trp-OMe·HCl D-tryptophan Methyl ester hydrochloride

(R)-Tryptophane Methyl Ester Hydrochloride

D-Trytophan Methyl ester hydrochloride

(R)-Methyl 2-aMino-3-(1H-indol-3-yl)propanoate hydrochloride

D-Trp-OCH3.Hcl

D-Tryptophan methyl ester hydrochloride≥ 99% (HPLC)

Methyl D-Tryptophanate Hydrochloride,99%e.e.

D-TRYPTOPHAN METHYL ESTER

D-TRYPTOPHAN METHYL ESTER HCL

D-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE

D-TRYPTOPHAN METHYL ESTER HYDROCHLORIDE SALT

D-TRYPTOPHAN-OME HCL

H-D-TRP-OME HCL

D-TRYPTOPHANE METHYL ESTER HCL

ANAM-002

D-Tryptophan, methyl ester, hydrochloride (1:1)

D-Tryptophan methyl ester hydrochloride USP/EP/BP

Julong Factory Supply High Quality CAS?14907-27-8?D-Tryptophan Powder

(2R)-Methyl 2-amino-3-(3H-indol-3-yl)propanoate hydrochloride

High purity 14907-27-8 D-Tryptophan methyl ester hydrochloride

Tadalafil Impurity 83 HCl

D-Tryptophane methyl ester hydrochloride Impurity

14907-27-8

14907-24-8

C12H14N2O2HCl

C12H15N2O2Cl

AMINE

Amino Acid Derivatives

Specialty Synthesis

Peptide Synthesis

Tryptophan

Intermediate of Tadalafil

tadalafil intermediate

Tryptophan

Tryptophan [Trp, W]

Amino Acids and Derivatives

Amino Acids 13C, 2H, 15N

Amino Acid Methyl Esters

Amino Acids (C-Protected)

Biochemistry

Amino hydrochloride

Amino Acids

Amino Acids Derivatives

Amino Acids & Derivatives

Amino Acid Derivatives