ChemicalBook > CAS DataBase List > 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

Product Name
5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
CAS No.
330792-70-6
Chemical Name
5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
Synonyms
IbrutinibN-3;IbrutinibIntermediate4;Ibrutinib intermediate3;Zanubrutinib Impurity 8;Zanubrutinib impurity-20;Ibrutinib intermediates N-3;Zanubrutinib Related Compound 6;3-AMino-4-cyano-5-(4-phenoxyphenyl)pyrazole;3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile;3-amino-5-(4-phenoxyphenyl)-1H-Pyrazole-4-carbonitrile
CBNumber
CB62604963
Molecular Formula
C16H12N4O
Formula Weight
276.29
MOL File
330792-70-6.mol
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5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Property

Boiling point:
585.3±50.0 °C(Predicted)
Density 
1.37±0.1 g/cm3(Predicted)
refractive index 
1.699
Flash point:
307.8℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly)
pka
10.83±0.50(Predicted)
InChI
InChI=1S/C16H12N4O/c17-10-14-15(19-20-16(14)18)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,(H3,18,19,20)
InChIKey
HNIMEQCLCNSCGH-UHFFFAOYSA-N
SMILES
N1C(C2=CC=C(OC3=CC=CC=C3)C=C2)=C(C#N)C(N)=N1
LogP
3.25298
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A603990
Product name
3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole
Packaging
100mg
Price
$165
Updated
2021/12/16
TRC
Product number
A603990
Product name
3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole
Packaging
1g
Price
$1320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0390612
Product name
5-AMINO-3-(4-PHENOXYPHENYL)-1H-PYRAZOLE-4-CARBONITRILE
Purity
95.00%
Packaging
5MG
Price
$496.69
Updated
2021/12/16
ChemScene
Product number
CS-M2596
Product name
1H-Pyrazole-4-carbonitrile,3-amino-5-(4-phenoxyphenyl)-
Purity
99.89%
Packaging
10g
Price
$165
Updated
2021/12/16
ChemScene
Product number
CS-M2596
Product name
1H-Pyrazole-4-carbonitrile,3-amino-5-(4-phenoxyphenyl)-
Purity
99.89%
Packaging
25g
Price
$340
Updated
2021/12/16
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5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Chemical Properties,Usage,Production

Chemical Properties

Light yellow to off-white powder.

Uses

3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole has been used as a reactant in the preparation of ring-fused pyrazole derivatives to be used a inhibitors of lymphocyte-specific kinase (Lck)

Application

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile is an intermediate of Ibrutinib (PCI-32765). it is a heterocyclic intermediate that typically used in the preparation of ACP-196, a selective second-generation BTK inhibitor.

5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile manufacturers

Nanjing Fred Technology Co., Ltd
Product
5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 330792-70-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-28
Henan Fengda Chemical Co., Ltd
Product
5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 330792-70-6
Price
US $10.00-3.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-29
Career Henan Chemical Co
Product
5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 330792-70-6
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-30

330792-70-6, 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrileRelated Search:

Vandetanib Vardenafil hydrochloride tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- 1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim (1R,3R)-Methyl-1,2,3,4-tetrahydro-2-chloroacetyl-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate ent-Tadalafil cis-ent-Tadalafil cis-Tadalafil (S)-1-Boc-3-hydroxypiperidine Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Chloropretadalafil Trelagliptin succinate Tadalafil (1R,3R)-Methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride 5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMine 3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine (R)-1-Boc-3-Hydroxypiperidine

  • 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
  • 3-amino-5-(4-phenoxyphenyl)-1H-Pyrazole-4-carbonitrile
  • 3-AMino-4-cyano-5-(4-phenoxyphenyl)pyrazole
  • 1H-Pyrazole-4-carbonitrile, 3-aMino-5-(4-phenoxyphenyl)-
  • 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile
  • Ibrutinib intermediates N-3
  • Zanubrutinib Related Compound 6
  • Zanubrutinib Impurity 8
  • Ibrutinib intermediate3
  • IbrutinibN-3
  • CAS330792-70-6 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
  • Zanubrutinib KSM-II : (4-isocyano-3-(4-phenoxyphenyl)-1H-pyrazol-5-amine)
  • Zanubrutinib impurity-8 (3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole
  • Zanubrutinib impurity-20
  • IbrutinibIntermediate4
  • 330792-70-6
  • 330790-70-6
  • 330792-70-6