N-BENZYL-L-ALANINOL
- Product Name
- N-BENZYL-L-ALANINOL
- CAS No.
- 6940-80-3
- Chemical Name
- N-BENZYL-L-ALANINOL
- Synonyms
- N-Bn-Ala-OL;amino)propan-1-oL;N-BENZYL-L-ALANINOL;(S)-N-benzylalaninol;(S)-2-(benzylaMino)propan-1-ol;(2S)-2-(benzylaMino)propan-1-ol;(S)-2-[(Phenylmethyl)amino]-1-propanol;1-Propanol, 2-[(phenylmethyl)amino]-, (2S)-
- CBNumber
- CB0419572
- Molecular Formula
- C10H15NO
- Formula Weight
- 165.23
- MOL File
- 6940-80-3.mol
N-BENZYL-L-ALANINOL Property
- Melting point:
- 47-49 °C(Solv: cyclohexane (110-82-7); ligroine (8032-32-4))
- Boiling point:
- 120-122 °C(Press: 6 Torr)
- Density
- 1.020±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- Chloroform; Methanol;
- form
- Solid
- pka
- 14.59±0.10(Predicted)
- color
- White
Safety
- HS Code
- 2922190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B233873
- Product name
- (S)-2-(Benzylamino)propan-1-ol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B233873
- Product name
- (S)-2-(Benzylamino)propan-1-ol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB144306
- Product name
- (S)-2-(Benzylamino)propan-1-ol
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- CS-M1051
- Product name
- (S)-2-(benzylamino)propan-1-ol
- Packaging
- 1g
- Price
- $117
- Updated
- 2021/12/16
- Product number
- FB144306
- Product name
- (S)-2-(Benzylamino)propan-1-ol
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
N-BENZYL-L-ALANINOL Chemical Properties,Usage,Production
Uses
(S)-2-(Benzylamino)propan-1-ol is a useful research chemical for the preparation of cross-benzoin products of heteroaromatic aldehydes and amino aldehydes.
Synthesis
2749-11-3
100-52-7
6940-80-3
Step 1: (S)-2-Amino-1-propanol (17.5 g, 233 mmol), benzaldehyde (26 g) and anhydrous magnesium sulfate (70 g) were dissolved in dichloromethane and the reaction was stirred for 19 hours at 25 °C. After completion of the reaction, the reaction solution was filtered and concentrated to give a yellow solid. The residue was dissolved in methanol and cooled to 0 °C. Sodium borohydride (11 g, 288 mmol) was added in batches at 0 °C (note gas generation). After addition, the reaction solution was continued to stir at 25°C for 18 hours. The reaction solution was concentrated and the residue was carefully quenched with 3M aqueous hydrochloric acid (note gas emission and exothermic phenomena). The aqueous phase was extracted with ether (4 x 200 mL). The aqueous phase was cooled to 0 °C and the pH was adjusted to 11-12 by the addition of sodium hydroxide pellets.The aqueous phase was extracted with dichloromethane, the organic phases were combined and dried with anhydrous magnesium sulfate. The dried organic phase was filtered and concentrated to give 23.2 g (60% yield) of the target product (S)-2-(benzylamino)propan-1-ol as a white solid.
References
[1] Tetrahedron, 1996, vol. 52, # 48, p. 15157 - 15170
[2] Synthetic Communications, 1994, vol. 24, # 10, p. 1415 - 1424
[3] Patent: WO2009/5646, 2009, A2. Location in patent: Page/Page column 219-220
[4] Tetrahedron Letters, 1995, vol. 36, # 46, p. 8391 - 8394
[5] Patent: US2006/14948, 2006, A1. Location in patent: Page/Page column 11
N-BENZYL-L-ALANINOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-BENZYL-L-ALANINOL manufacturers
- Product
- (2S)-2-(benzylamino)propan-1-ol 6940-80-3
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09