2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE

Product Name: 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE
CAS No.: 115199-84-3
Chemical Name: 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE
Synonyms: ICI 199;ICI 199441;ICI199441HCl;441 hydrochloride;ICI 199,441 HYDROCHLORIDE;ICI 199,441 hydrochloride, 10 mM in DMSO;(S)-2-(3,4-Dichlorophenyl)-N-methyl-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide hydrochloride;2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE
CBNumber: CB0422208
Molecular Formula: C21H25Cl3N2O
Formula Weight: 427.8
MOL File: 115199-84-3.mol

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2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Property

storage temp.: Store at RT
solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol
form: White solid.
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 0778
Product name: ICI199,441hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $154
Updated: 2021/12/16

Tocris

Product number: 0778
Product name: ICI199,441hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $638
Updated: 2021/12/16

TRC

Product number: I163820
Product name: ICI199441
Packaging: 100mg
Price: $1135
Updated: 2021/12/16

TRC

Product number: I163820
Product name: ICI199441
Packaging: 50mg
Price: $580
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009975
Product name: ICI 199,441 HYDROCHLORIDE
Purity: 95.00%
Packaging: 1MG
Price: $144.9
Updated: 2021/12/16

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2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Opioid agonists exert a broad range of effects on the immune system ranging from inflammatory response modulation to opioid and chemokine receptor expression. ICI 199441 is a selective κ-opioid agonist with analgesic properties.

Biological Activity

Highly potent κ agonist, 146-fold more active than U-50488 (trans-(?-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride ) in vitro .

in vivo

ICI 199441 (Wistar rats, 0.1 mg/kg, IV, once) administered 15 min before ischemia produces a potent antiarrhythmic effect^[1].

IC 50

κ Opioid Receptor/KOR

storage

Store at RT

2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Suppliers

China 39 Germany 1 Switzerland 2 United Kingdom 2 United States 5 USA 1 Global 50

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115199-84-3, 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDERelated Search:

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide (S)-ALPHA-PHENYL-1-PYRROLIDINEETHANAMINE 1,2-Ethanediamine,N2,N2-dimethyl-1-phenyl-,(1S)-(9CI) 2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE (R)-(-)-N-METHYL-1-PHENYL-2-(1-PYRROLIDINO)ETHYLAMINE DIPPA HYDROCHLORIDE

2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE

ICI 199,441 HYDROCHLORIDE

ICI199441HCl

ICI 199441

441 hydrochloride

ICI 199

(S)-2-(3,4-Dichlorophenyl)-N-methyl-N-(1-phenyl-2-(pyrrolidin-1-yl)ethyl)acetamide hydrochloride

ICI 199,441 hydrochloride, 10 mM in DMSO

115199-84-3

C21H24Cl2N2OHCl