ChemicalBook > CAS DataBase List > ZOPICLONE N-OXIDE

ZOPICLONE N-OXIDE

Product Name
ZOPICLONE N-OXIDE
CAS No.
43200-96-0
Chemical Name
ZOPICLONE N-OXIDE
Synonyms
RP 2975;RP 29753;ZOPICLONE N-OXIDE;Eszopiclone IMpurity A;Zopiclone EP Impurity A;Zopiclone-N-oxide solution;Eszopiclone Related CoMpound A;ZOPICLONE EP IMPURITY A (N-OXIDE);Zopiclone N-Oxide Solution, 100ppm;Eszopiclone USP Related Compound A
CBNumber
CB0428563
Molecular Formula
C17H17ClN6O4
Formula Weight
404.81
MOL File
43200-96-0.mol
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ZOPICLONE N-OXIDE Property

Melting point:
>140°C (dec.)
Flash point:
9℃
storage temp. 
2-8°C
solubility 
Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form 
liquid
pka
4.92±0.20(Predicted)
color 
White to Light Brown
InChI
InChI=1S/C17H17ClN6O4/c1-24(27)8-6-22(7-9-24)17(26)28-16-14-13(19-4-5-20-14)15(25)23(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3
InChIKey
IPTIKKTXLHVRKN-UHFFFAOYSA-N
SMILES
N1(C(OC2C3=NC=CN=C3C(=O)N2C2=NC=C(Cl)C=C2)=O)CC[N+]([O-])(C)CC1
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol
WGK Germany 
1
HS Code 
2933790002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Z3001000
Product name
Zopiclone oxide
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
20 mg
Price
$156
Updated
2025/07/31
Sigma-Aldrich
Product number
Z-013
Product name
Zopiclone-N-oxide solution
Purity
100?μg/mL (Methanol with 1% 1 M HCl), ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$161
Updated
2025/07/31
Sigma-Aldrich
Product number
1255861
Product name
Zopiclone-N-oxide solution
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
10mg
Price
$1300
Updated
2025/07/31
Sigma-Aldrich
Product number
Z3001000
Product name
Zopiclone oxide
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
z3001000
Price
$153
Updated
2024/03/01
Usbiological
Product number
292130
Product name
Zopiclone N-oxide
Packaging
2mg
Price
$425
Updated
2021/12/16
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ZOPICLONE N-OXIDE Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Beige Solid

Uses

A metabolite of Zopiclone

Uses

Eszopiclone impurity A.

General Description

Zopiclone N-oxide is a primary, active metabolite of zopiclone in urine as well as a major pharmaceutical impurity of zopiclone known as eszopiclone impurity A. The parent drug, zopiclone, is a non-benzodiazepine hypnotic sold under the trade names Imovane?and ZImovane?and is used in the treatment of insomnia.

ZOPICLONE N-OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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43200-96-0, ZOPICLONE N-OXIDERelated Search:

6-(5-Chloro-2-pyridyl)-6,7-dihydro-7-hydroxy-5H-pyrrolo[3,4-b]pyrazin-5-one Eszopiclone Levetiracetam impurity 1 N-(5-Chloro-2-pyridinyl)-2-pyrazinecarboxaMide (Zopiclone IMpurity) 2-Amino-5-chloropyridine N-Desmethyl Zopiclone HCl Zopiclone RP 48497 (Eszopiclone Impurity C) N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide ZOPICLONE OXIDE Zopiclone iMpurity (5-(Chloropyridine-2-yl-carbaMoyl)pyrazine) Zopiclone iMpurity A 1-Piperazinecarboxylicacid,4-methyl-,ethylester(6CI,9CI) Zopiclone Impurity 10 Zopiclone Impurity 18 Zopiclone Impurity 3 Deschloro-Zopiclone N-Boc-N-desmethyl Zopiclone

  • RP 2975
  • 1-Piperazine-carboxylic Acid 4-Methyl-4-oxide 6-(5-Chloro-pyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5yl Ester
  • Zopiclone N-Oxide (Mixture of diastereomers)
  • RP 29753
  • Zopiclone N-Oxide (Eszopiclone Impurity A) (Mixture of Diastereomers)
  • Zopiclone N-Oxide (Eszopiclone Impurity A)
  • ZOPICLONE N-OXIDE
  • 4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester 4-oxide
  • Eszopiclone IMpurity A
  • Eszopiclone Related CoMpound A
  • (5RS)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate 4-oxide
  • Dexzopiclone impurity A (zopiclone nitrogen oxide)
  • Zopiclone N-Oxide Solution, 100ppm
  • Zopiclone-N-oxide solution
  • Zopiclone Impurity A (Zopiclone N-Oxide)
  • 4-(((6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl)oxy)carbonyl)-1-methylpiperazine1-oxide
  • Zopiclone Impurity 1 (Zopiclone EP Impurity A)
  • Zopiclone EP Impurity A (Zopiclone N-Oxide)
  • Zopiclone EP Impurity A
  • [6-(5-chloropyridin-2-yl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methyl-4-oxidopiperazin-4-ium-1-carboxylate
  • 6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate 4-oxide
  • 1-Piperazinecarboxylic acid, 4-methyl-, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester, 4-oxide
  • 6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]...
  • Zopiclone N-OxideQ: What is Zopiclone N-Oxide Q: What is the CAS Number of Zopiclone N-Oxide Q: What is the storage condition of Zopiclone N-Oxide Q: What are the applications of Zopiclone N-Oxide
  • Eszopiclone Related Compound A (6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo [3,4,b] pyraz (1255861)
  • Eszopiclone USP Related Compound A
  • (5RS)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-Methylpiperazine-1-
  • ZOPICLONE EP IMPURITY A (N-OXIDE)
  • (5RS)-6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-Methylpiperazine-1-carboxylate 4-Oxide (Zopiclone Oxide)
  • Zopiclone Oxide 1.0 mg/ml in Dimethyl Sulfoxide
  • Zopiclone Imp.A (EP): (5RS)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate 4-oxide (zopiclone oxide)
  • 43200-96-0
  • C17H17ClN6O4
  • Isotopically Labeled Pharmaceutical Reference Standard
  • Heterocycles
  • Impurities
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals