(RS)-(TETRAZOL-5-YL)GLYCINE

Product Name: (RS)-(TETRAZOL-5-YL)GLYCINE
CAS No.: 138199-51-6
Chemical Name: (RS)-(TETRAZOL-5-YL)GLYCINE
Synonyms: C13738;LY 285265;Tet-glycine;Tetrazolyl Glycine;5-Tetrazolyl-glycine;(RS)-(Tetrazol-5-yl);(tetrazol-5-yl)glycine;L-(tetrazol-5-yl)glycine;(RS)-(TETRAZOL-5-YL)GLYCINE;aMino(2H-tetrazol-5-yl)acetic acid
CBNumber: CB0429449
Molecular Formula: C3H5N5O2
Formula Weight: 143.1
MOL File: 138199-51-6.mol

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(RS)-(TETRAZOL-5-YL)GLYCINE Property

Boiling point:: 447.1±55.0 °C(Predicted)
Density: 1.804±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: DMSO: 0.25mg/mL; PBS (pH 7.2): 0.2mg/mL
form: Powder
pka: 1.04±0.10(Predicted)
Water Solubility: Soluble to 50 mM in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28408
Product name: Tetrazolyl Glycine
Packaging: 10mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 28408
Product name: Tetrazolyl Glycine
Packaging: 100mg
Price: $693
Updated: 2021/12/16

Cayman Chemical

Product number: 28408
Product name: Tetrazolyl Glycine
Packaging: 25mg
Price: $287
Updated: 2024/03/01

Cayman Chemical

Product number: 28408
Product name: Tetrazolyl Glycine
Packaging: 50mg
Price: $543
Updated: 2024/03/01

Tocris

Product number: 0312
Product name: (RS)-(Tetrazol-5-yl)glycine
Purity: ≥98%(HPLC)
Packaging: 50
Price: $910
Updated: 2021/12/16

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(RS)-(TETRAZOL-5-YL)GLYCINE Chemical Properties,Usage,Production

Description

Tetrazolyl glycine is an NMDA receptor agonist. It binds to rat brain membranes with IC₅₀ values of 98 and 36 nM for [³H]CGS19755 and [³H]glutamate, respectively, in radioligand binding assays. It induces depolarization in rat cortical slices, an effect that is blocked by the NMDA receptor antagonist LY233053. It induces degeneration of GABAergic and cholinergic neurons in the striatum of adult rats and the formation of excitotoxic lesions and seizures in neonatal rats (ED₅₀ = 0.071 mg/kg). Intrastriatal injection of tetrazolyl glycine (5 μM) increases COX-2 expression in striatal neurons and the vasculature near the striatal injection site in a mouse model of excitotoxicity-induced neuronal injury.

Uses

(RS)-(Tetrazol-5-yl)glycine is a highly potent NMDA receptor agonist demonstrating ~ 20X more activity than NMDA.

Definition

ChEBI: Tet-glycine is a non-proteinogenic alpha-amino acid.

storage

Store at RT

(RS)-(TETRAZOL-5-YL)GLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(RS)-(TETRAZOL-5-YL)GLYCINE Suppliers

China 24 Germany 1 Japan 2 South Korea 1 Ukraine 1 United Kingdom 3 United States 7 USA 1 Global 40

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138199-51-6, (RS)-(TETRAZOL-5-YL)GLYCINERelated Search:

5-aminotetrazole Lauroyl glycine SALOR-INT L159409-1EA 2-(2H-TETRAZOL-5-YL)-ETHANOL 1H-TETRAZOLE-5-ACETIC ACID C-(2H-TETRAZOL-5-YL)-METHYLAMINE (RS)-(TETRAZOL-5-YL) GLYCINE, [GLYCINE-1-14C] (RS)-(TETRAZOL-5-YL)GLYCINE CHEMBRDG-BB 4015694

(RS)-(TETRAZOL-5-YL)GLYCINE

(tetrazol-5-yl)glycine

5-Tetrazolyl-glycine

C13738

Tet-glycine

aMino(2H-tetrazol-5-yl)acetic acid

Amino-(1H-tetrazol-5-yl)-acetic acid

2H-Tetrazole-5-acetic acid, a-amino-

alpha-Amino-2H-tetrazole-5-acetic acid

LY 285265

2H-Tetrazole-5-acetic acid, α-amino-

(RS)-(Tetrazol-5-yl)

2-Amino-2-(2H-tetrazol-5-yl)acetic acid

Tetrazolyl Glycine

(RS)-(Tetrazol-5-yl)glycine/LY285265

L-(tetrazol-5-yl)glycine

Fos,iGluR,GluN2D,LY-285265,Ionotropic glutamate receptors,inhibit,Inhibitor,(RS)(Tetrazol5yl)glycine,GluN1,(RS) (Tetrazol 5 yl)glycine,GluN2A,LY285265,NMDA,seizure

2H-Tetrazole-5-acetic acid, α-amino-

138199-51-6