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(RS)-(TETRAZOL-5-YL)GLYCINE

Product Name
(RS)-(TETRAZOL-5-YL)GLYCINE
CAS No.
138199-51-6
Chemical Name
(RS)-(TETRAZOL-5-YL)GLYCINE
Synonyms
C13738;LY 285265;Tet-glycine;Tetrazolyl Glycine;5-Tetrazolyl-glycine;(RS)-(Tetrazol-5-yl);(tetrazol-5-yl)glycine;L-(tetrazol-5-yl)glycine;(RS)-(TETRAZOL-5-YL)GLYCINE;aMino(2H-tetrazol-5-yl)acetic acid
CBNumber
CB0429449
Molecular Formula
C3H5N5O2
Formula Weight
143.1
MOL File
138199-51-6.mol
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(RS)-(TETRAZOL-5-YL)GLYCINE Property

Boiling point:
447.1±55.0 °C(Predicted)
Density 
1.804±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: 0.25mg/mL; PBS (pH 7.2): 0.2mg/mL
form 
Powder
pka
1.04±0.10(Predicted)
Water Solubility 
Soluble to 50 mM in water
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28408
Product name
Tetrazolyl Glycine
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
28408
Product name
Tetrazolyl Glycine
Packaging
100mg
Price
$693
Updated
2021/12/16
Cayman Chemical
Product number
28408
Product name
Tetrazolyl Glycine
Packaging
25mg
Price
$287
Updated
2024/03/01
Cayman Chemical
Product number
28408
Product name
Tetrazolyl Glycine
Packaging
50mg
Price
$543
Updated
2024/03/01
Tocris
Product number
0312
Product name
(RS)-(Tetrazol-5-yl)glycine
Purity
≥98%(HPLC)
Packaging
50
Price
$910
Updated
2021/12/16
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(RS)-(TETRAZOL-5-YL)GLYCINE Chemical Properties,Usage,Production

Description

Tetrazolyl glycine is an NMDA receptor agonist. It binds to rat brain membranes with IC50 values of 98 and 36 nM for [3H]CGS19755 and [3H]glutamate, respectively, in radioligand binding assays. It induces depolarization in rat cortical slices, an effect that is blocked by the NMDA receptor antagonist LY233053. It induces degeneration of GABAergic and cholinergic neurons in the striatum of adult rats and the formation of excitotoxic lesions and seizures in neonatal rats (ED50 = 0.071 mg/kg). Intrastriatal injection of tetrazolyl glycine (5 μM) increases COX-2 expression in striatal neurons and the vasculature near the striatal injection site in a mouse model of excitotoxicity-induced neuronal injury.

Uses

(RS)-(Tetrazol-5-yl)glycine is a highly potent NMDA receptor agonist demonstrating ~ 20X more activity than NMDA.

Definition

ChEBI: Tet-glycine is a non-proteinogenic alpha-amino acid.

storage

Store at RT

(RS)-(TETRAZOL-5-YL)GLYCINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(RS)-(TETRAZOL-5-YL)GLYCINE Suppliers

China 24 Germany 1 Japan 2 South Korea 1 Ukraine 1 United Kingdom 3 United States 7 USA 1 Global 40
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138199-51-6, (RS)-(TETRAZOL-5-YL)GLYCINERelated Search:

5-aminotetrazole Lauroyl glycine SALOR-INT L159409-1EA 2-(2H-TETRAZOL-5-YL)-ETHANOL 1H-TETRAZOLE-5-ACETIC ACID C-(2H-TETRAZOL-5-YL)-METHYLAMINE (RS)-(TETRAZOL-5-YL) GLYCINE, [GLYCINE-1-14C] (RS)-(TETRAZOL-5-YL)GLYCINE CHEMBRDG-BB 4015694

  • (RS)-(TETRAZOL-5-YL)GLYCINE
  • (tetrazol-5-yl)glycine
  • 5-Tetrazolyl-glycine
  • C13738
  • Tet-glycine
  • aMino(2H-tetrazol-5-yl)acetic acid
  • Amino-(1H-tetrazol-5-yl)-acetic acid
  • 2H-Tetrazole-5-acetic acid, a-amino-
  • alpha-Amino-2H-tetrazole-5-acetic acid
  • LY 285265
  • 2H-Tetrazole-5-acetic acid, α-amino-
  • (RS)-(Tetrazol-5-yl)
  • 2-Amino-2-(2H-tetrazol-5-yl)acetic acid
  • Tetrazolyl Glycine
  • (RS)-(Tetrazol-5-yl)glycine/LY285265
  • L-(tetrazol-5-yl)glycine
  • Fos,iGluR,GluN2D,LY-285265,Ionotropic glutamate receptors,inhibit,Inhibitor,(RS)(Tetrazol5yl)glycine,GluN1,(RS) (Tetrazol 5 yl)glycine,GluN2A,LY285265,NMDA,seizure
  • 2H-Tetrazole-5-acetic acid, α-amino-
  • 138199-51-6