FRACTALKINE, HUMAN
Description Source Background- Product Name
- FRACTALKINE, HUMAN
- Chemical Name
- FRACTALKINE, HUMAN
- Synonyms
- CX3CL-1;CX36, HUMAN;NEUROTACTIN;HUMAN CX3CL1;CX3C (HUMAN);FRACTALKALINE;NEUROTACTIN HUMAN;HUMAN NEUROTACTIN;HUMAN FRACTALKINE;FRACTALKINE, HUMAN
- CBNumber
- CB0430050
- Formula Weight
- 0
- MOL File
- Mol file
FRACTALKINE, HUMAN Property
- storage temp.
- −20°C
- form
- lyophilized powder
- biological source
- mouse
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 23/24/25-36/37/38-36/38
- Safety Statements
- 26-36/37/39-45-24/25-22
- WGK Germany
- -
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Dam. 1
Skin Irrit. 2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F2302
- Product name
- Fractalkine, Chemokine Domain from mouse
- Purity
- >97% (SDS-PAGE), recombinant, expressed in <I>E. coli</I>, lyophilized powder
- Packaging
- 25 μg
- Price
- $666
- Updated
- 2025/07/31
- Product number
- 382575
- Product name
- CX3CL1
- Packaging
- 96Tests
- Price
- $729
- Updated
- 2021/12/16
- Product number
- 382573
- Product name
- CX3CL1
- Packaging
- 96Tests
- Price
- $729
- Updated
- 2021/12/16
- Product number
- 382574
- Product name
- CX3CL1
- Packaging
- 96Tests
- Price
- $729
- Updated
- 2021/12/16
- Product number
- 139699
- Product name
- CX3CL1
- Packaging
- 200ul
- Price
- $426
- Updated
- 2021/12/16
FRACTALKINE, HUMAN Chemical Properties,Usage,Production
Uses
CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is a membrane protein, which is the only member of CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. It acts as a ligand for the G-protein coupled receptor CX3CR1, which is found on smooth muscle cells, T-cells, natural killer (NK) cells and monocytes. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and neurons.
Biological Activity
CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine, along with CX3CR1 is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)-dependent manner. It plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it is thought to be involved in atherogenesis, and thus, might have potential as a target in treatment of cardiovascular disease. In patients with sickle cell disease (SCD), the serum levels of this chemokine is increased, thus implicating it in the pathogenesis of inflammation associated with SCD.', 'Leukocyte chemoattractant protein and member of the chemokine superfamily possessing a CX3C motif. Mouse fractalkine is chemotactic for neutrophils and T-lymphocytes but not monocytes.
Description
Fractalkine Human Recombinant- produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 76 amino acids and having a molecular mass of 8638 Dalton.
The Fractalkine is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
Fractalkine soluble form is chemotactic for t-cells and monocytes, but not for neutrophils. Fractalkine membrane-bound form promotes adhesion of those leukocytes to endothelial cells. Fractalkine regulates leukocyte adhesion and migration processes at the endothelium and binds to CX3CR1. Natural Human Fractalkine is produced as a long protein (373-amino acid) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the cell surface. Fractalkine gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22.
FRACTALKINE, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
FRACTALKINE, HUMAN Suppliers
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