3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

Product Name: 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
CAS No.: 1005-24-9
Chemical Name: 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
Synonyms: 1-METHYLNICOTINAMIDE CHLORIDE;TRIA-662;Trionellamide chloride;TRIGONELLAMIDE CHLORIDE;nicotinamidemethochloride;nipecotamidemethochloride;Nicotinamide Impurity 127;nicotinamidemethylchloride;NICOTINAMIDE CHLOROMETHYLATE;n-methylnicotinamidechloride
CBNumber: CB0431956
Molecular Formula: C7H9ClN2O
Formula Weight: 172.61
MOL File: 1005-24-9.mol

More

Less

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Property

Melting point:: 207-209℃ (water acetone )
storage temp.: room temp
solubility: H2O: soluble15mg/mL, clear
form: crystalline
color: white
Water Solubility: almost transparency
Merck: 14,9693
CAS DataBase Reference: 1005-24-9(CAS DataBase Reference)

More

Less

Safety

WGK Germany: 3
RTECS: UU1925000
HS Code: 2933.39.9200

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0704
Product name: 1-Methylnicotinamide chloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $44.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: M4627
Product name: 1-Methylnicotinamide chloride
Purity: analytical standard
Packaging: 1g
Price: $180
Updated: 2024/03/01

TCI Chemical

Product number: M0375
Product name: 3-Carbamyl-1-methylpyridinium Chloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $239
Updated: 2024/03/01

TCI Chemical

Product number: M0375
Product name: 3-Carbamyl-1-methylpyridinium Chloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $695
Updated: 2024/03/01

Cayman Chemical

Product number: 16604
Product name: 1-Methylnicotinamide (chloride)
Purity: ≥95%
Packaging: 100mg
Price: $32
Updated: 2024/03/01

More

Less

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Chemical Properties,Usage,Production

Description

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

Uses

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).

Uses

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

General Description

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Biochem/physiol Actions

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

Purification Methods

Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Suppliers

Americas 1 China 64 Europe 1 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 4 United States 13 Global 91

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9664
Advantage: 60

Shanghai Nuohey Chemical Co., Ltd.

Tel: 021-52212593 13761626812
Fax: +86 (21) 51062076
Email: sales@nuohey.com
Country: China
ProdList: 7135
Advantage: 60

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19918
Advantage: 55

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28398
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23680
Advantage: 75

TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23662
Advantage: 75

More

Less

View Lastest Price from 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-11

1005-24-9, 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDERelated Search:

1-Methylpyridinium chloride HS 6 3-(AMINOCARBONYL)-1-BENZYLPYRIDINIUM CHLORIDE 3-(AMINOCARBONYL)-1-(4-METHYLBENZYL)PYRIDINIUM CHLORIDE 3-(AMINOCARBONYL)-1-(4-CHLOROBENZYL)PYRIDINIUM CHLORIDE 2-ISOPROPYL-5-METHYLCYCLOHEXYL 2-(3-[(BENZYLAMINO)CARBONYL]PYRIDINIUM-1-YL)ACETATE CHLORIDE 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 3-CARBAMOYL-1-DODECYLOXYCARBONYLMETHYL-PYRIDINIUM CHLORIDE CORAMINEMETHOCHLORIDE

NICOTINAMIDE CHLOROMETHYLATE

N-METHYLNICOTINIC ACID AMIDE CHLORIDE SALT

N1-METHYLNICOTINAMIDE CHLORIDE

TRIGONELLAMIDE CHLORIDE

3-(aminocarbonyl)-1-methyl-pyridiniuchloride

3-carbamoyl-1-methyl-pyridiniuchloride

nicotinamidemethochloride

nicotinamidemethylchloride

1-METHYLPYRIDINE-3-CARBOXYLIC ACID AMIDE CHLORIDE

1-METHYLNICOTINAMIDE CHLORIDE

1-METHYLNICOTINAMIDE CHLORIDE SALT

3-CARBAMOYL-1-METHYLPYRIDINIUM CHLORIDE

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

nipecotamidemethochloride

n-methylnicotinamidechloride

n-methylnicotinic acid amide chloride

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 98+%

3-Carbamoyl-1-methylpyridinium Chloride 1-Methylnicotinamide Chloride Nicotinamide Chloromethylate

3-Carbamyl-1-methylpyridiniumChloride&gt

1-methylpyridin-1-ium-3-carboxamide hydrochloride

Nicotinamide 1-Methyl Chloride

Trionellamide chloride

3-Carbamoyl-1-methylpyridin-1-ium chloride

2-ACETYL-5-CHLORO-40-METHYLTHIANAPHTHENE

TRIA-662

inhibit,1-Methylnicotinamide,N-methylnicotinamide,Inhibitor,Endogenous Metabolite,TRIA 662,anti-inflammatory activity,antithrombotic activity,HMECs,TRIA-662,TRIA662

Nicotinamide Impurity 127

1005-24-9

Urinary excretion product of niacin metabolism

Pyridinium Compounds

Analytical Chromatography Product Catalog

Alphabetic

Analytical Standards

META - METH

Pyridinium Compounds