3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
- Product Name
- 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
- CAS No.
- 1005-24-9
- Chemical Name
- 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
- Synonyms
- 1-METHYLNICOTINAMIDE CHLORIDE;TRIA-662;Trionellamide chloride;TRIGONELLAMIDE CHLORIDE;TRIA-662, 10 mM in DMSO;Nicotinamide Impurity F;nicotinamidemethochloride;nipecotamidemethochloride;1-Methylnicotine Chloride;Nicotinamide Impurity 127
- CBNumber
- CB0431956
- Molecular Formula
- C7H9ClN2O
- Formula Weight
- 172.61
- MOL File
- 1005-24-9.mol
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Property
- Melting point:
- 207-209℃ (water acetone )
- storage temp.
- room temp
- solubility
- H2O: soluble15mg/mL, clear
- form
- crystalline
- color
- white
- Water Solubility
- almost transparency
- Merck
- 14,9693
- CAS DataBase Reference
- 1005-24-9(CAS DataBase Reference)
Safety
- WGK Germany
- 3
- RTECS
- UU1925000
- HS Code
- 2933.39.9200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- SML0704
- Product name
- 1-Methylnicotinamide chloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $45.3
- Updated
- 2025/07/31
- Product number
- PHR2091
- Product name
- Nicotinamide Impurity F
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 100 mg
- Price
- $511.1
- Updated
- 2025/07/31
- Product number
- M4627
- Product name
- 1-Methylnicotinamide chloride
- Purity
- analytical standard
- Packaging
- 1g
- Price
- $184
- Updated
- 2025/07/31
- Product number
- M0375
- Product name
- 3-Carbamyl-1-methylpyridinium Chloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $208
- Updated
- 2025/07/31
- Product number
- M0375
- Product name
- 3-Carbamyl-1-methylpyridinium Chloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $604
- Updated
- 2025/07/31
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Chemical Properties,Usage,Production
Description
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
Uses
1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Uses
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
General Description
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.
Biochem/physiol Actions
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.
Purification Methods
Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]
References
[1] THEODORE A. ALSTON Robert H A. Substrate specificity of nicotinamide methyltransferase isolated from porcine liver[J]. Archives of biochemistry and biophysics, 1988, 260 2: Pages 601-608. DOI: 10.1016/0003-9861(88)90487-0
[2] TERESA B DOMAGALA. Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels.[J]. Hypertension, 2012, 59 4: 825-832. DOI: 10.1161/hypertensionaha.111.183210
[3] S CHLOPICKI. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway[J]. British Journal of Pharmacology, 2009, 152 2: 230-239. DOI: 10.1038/sj.bjp.0707383
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE manufacturers
- Product
- 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-19
- Product
- 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-07-25
- Product
- 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11