ChemicalBook > CAS DataBase List > 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

Product Name
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
CAS No.
1005-24-9
Chemical Name
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
Synonyms
1-METHYLNICOTINAMIDE CHLORIDE;TRIA-662;Trionellamide chloride;TRIGONELLAMIDE CHLORIDE;nicotinamidemethochloride;nipecotamidemethochloride;Nicotinamide Impurity 127;nicotinamidemethylchloride;NICOTINAMIDE CHLOROMETHYLATE;n-methylnicotinamidechloride
CBNumber
CB0431956
Molecular Formula
C7H9ClN2O
Formula Weight
172.61
MOL File
1005-24-9.mol
More
Less

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Property

Melting point:
207-209℃ (water acetone )
storage temp. 
room temp
solubility 
H2O: soluble15mg/mL, clear
form 
crystalline
color 
white
Water Solubility 
almost transparency
Merck 
14,9693
CAS DataBase Reference
1005-24-9(CAS DataBase Reference)
More
Less

Safety

WGK Germany 
3
RTECS 
UU1925000
HS Code 
2933.39.9200
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0704
Product name
1-Methylnicotinamide chloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$44.1
Updated
2024/03/01
Sigma-Aldrich
Product number
M4627
Product name
1-Methylnicotinamide chloride
Purity
analytical standard
Packaging
1g
Price
$180
Updated
2024/03/01
TCI Chemical
Product number
M0375
Product name
3-Carbamyl-1-methylpyridinium Chloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$239
Updated
2024/03/01
TCI Chemical
Product number
M0375
Product name
3-Carbamyl-1-methylpyridinium Chloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$695
Updated
2024/03/01
Cayman Chemical
Product number
16604
Product name
1-Methylnicotinamide (chloride)
Purity
≥95%
Packaging
100mg
Price
$32
Updated
2024/03/01
More
Less

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Chemical Properties,Usage,Production

Description

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

Uses

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).

Uses

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

General Description

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Biochem/physiol Actions

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

Purification Methods

Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Suppliers

Americas 1 China 65 Europe 1 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 4 United States 13 Global 92
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40240
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
Shanghai Shenyue Chemical Co., Ltd.
Tel
021-021-52212593 15300879511
Fax
+86 (21) 51062076
Email
sales@nuohey.com
Country
China
ProdList
5115
Advantage
60
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19918
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4528
Advantage
56
Huainan Kedi Chemical Factory
Tel
0554-2106669
Fax
0554-2666215
Email
sales1@kedichem.com
Country
China
ProdList
4928
Advantage
55
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13359
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15878
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20810
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9980
Advantage
55
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
9998
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19806
Advantage
60
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
400-400-400-9004166 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52712
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
6912
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3063
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6870
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
0551-65418671
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34572
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
CHINA
ProdList
52867
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6313
Advantage
58
Zhengzhou anmousse chemical products co. LTD
Tel
0371-55289822 18737195735
Fax
QQ:483339295
Email
483339295@qq.com
Country
China
ProdList
7088
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 15093356674;
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29826
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
18501792038; 18501792038
Email
shanpel@anpel.com.cn
Country
China
ProdList
9614
Advantage
58
Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd
Tel
13522808617
Email
omiget@qq.com
Country
China
ProdList
9213
Advantage
58
Changzhou Kechem Bio-Scientific Co., LTD.
Tel
0519-68985668 13685222090
Fax
qq735434464
Email
sales@kechem.cn
Country
China
ProdList
26033
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8141
Advantage
58
Yantai Boyun Biological Technology Co. Ltd
Tel
13793517650; 13793517650
Email
2767277144@qq.com
Country
China
ProdList
2870
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44489
Advantage
58
Hubei Shishun Biotechnology Co. Ltd
Tel
027-59223025 15107168801
Fax
027-59223025
Email
1718480011@qq.com
Country
China
ProdList
9981
Advantage
58
Tianmen Hengchang Chemical Co., Ltd
Tel
027-59322316 15172518801
Fax
027-59322316
Email
1208480077@qq.com
Country
China
ProdList
9941
Advantage
58
Shandong Tianming Biotechnology Development Co. Ltd
Tel
400-9019001
Country
China
ProdList
15070
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
Advantage
58
Yancheng Tongming Biotechnology Co., Ltd.
Tel
15195160625
Email
2863565288@qq.com
Country
China
ProdList
5194
Advantage
58
Hu' nan Yunbang Pharmaceutical Co., Ltd.
Tel
0731-85561020 15386497078
Email
yunbang@yunbangapi.com
Country
China
ProdList
4219
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Email
product02@bidepharm.com
Country
China
ProdList
61720
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18488
Advantage
58
Shanghai Hansi Chemical Industry Co., Ltd.
Tel
17717618050
Email
zllg@gh-reagent.com
Country
China
ProdList
10424
Advantage
58
Yantai Zhengxin New Material Technology Co. LTD
Tel
15065715832; 13854547682
Email
542660804@qq.com
Country
China
ProdList
3466
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24023
Advantage
58
Henan Dobe Chemical Co. , Ltd.
Tel
0370-6999054 17334723986
Email
2794293116@qq.com
Country
China
ProdList
1334
Advantage
58
Shanghai Yiyan Biotechnology Co. , Ltd.
Tel
021-69985186 13611928337
Email
3427709316@qq.com
Country
China
ProdList
7984
Advantage
58
Yantai Sheng Kai Lun Biological Products Co. , Ltd.
Tel
3119594100
Email
mark@sklnchem.cn
Country
China
ProdList
7152
Advantage
58
Beijing Keyi Tongda Technology Development Co., Ltd
Tel
13681252203
Email
kytd20@sina.com
Country
China
ProdList
1178
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
8740
Advantage
58
Liaocheng Lebote Biopharmaceutical Technology Co., Ltd
Tel
0635-893290 18663513896;
Email
28698871@qq.com
Country
China
ProdList
8531
Advantage
58
More
Less

View Lastest Price from 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-11

1005-24-9, 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDERelated Search:

1-Methylpyridinium chloride HS 6 3-(AMINOCARBONYL)-1-BENZYLPYRIDINIUM CHLORIDE 3-(AMINOCARBONYL)-1-(4-METHYLBENZYL)PYRIDINIUM CHLORIDE 3-(AMINOCARBONYL)-1-(4-CHLOROBENZYL)PYRIDINIUM CHLORIDE 2-ISOPROPYL-5-METHYLCYCLOHEXYL 2-(3-[(BENZYLAMINO)CARBONYL]PYRIDINIUM-1-YL)ACETATE CHLORIDE 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 3-CARBAMOYL-1-DODECYLOXYCARBONYLMETHYL-PYRIDINIUM CHLORIDE CORAMINEMETHOCHLORIDE

  • NICOTINAMIDE CHLOROMETHYLATE
  • N-METHYLNICOTINIC ACID AMIDE CHLORIDE SALT
  • N1-METHYLNICOTINAMIDE CHLORIDE
  • TRIGONELLAMIDE CHLORIDE
  • 3-(aminocarbonyl)-1-methyl-pyridiniuchloride
  • 3-carbamoyl-1-methyl-pyridiniuchloride
  • nicotinamidemethochloride
  • nicotinamidemethylchloride
  • 1-METHYLPYRIDINE-3-CARBOXYLIC ACID AMIDE CHLORIDE
  • 1-METHYLNICOTINAMIDE CHLORIDE
  • 1-METHYLNICOTINAMIDE CHLORIDE SALT
  • 3-CARBAMOYL-1-METHYLPYRIDINIUM CHLORIDE
  • 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
  • nipecotamidemethochloride
  • n-methylnicotinamidechloride
  • n-methylnicotinic acid amide chloride
  • 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 98+%
  • 3-Carbamoyl-1-methylpyridinium Chloride 1-Methylnicotinamide Chloride Nicotinamide Chloromethylate
  • 3-Carbamyl-1-methylpyridiniumChloride&gt
  • 1-methylpyridin-1-ium-3-carboxamide hydrochloride
  • Nicotinamide 1-Methyl Chloride
  • Trionellamide chloride
  • 3-Carbamoyl-1-methylpyridin-1-ium chloride
  • 2-ACETYL-5-CHLORO-40-METHYLTHIANAPHTHENE
  • TRIA-662
  • inhibit,1-Methylnicotinamide,N-methylnicotinamide,Inhibitor,Endogenous Metabolite,TRIA 662,anti-inflammatory activity,antithrombotic activity,HMECs,TRIA-662,TRIA662
  • Nicotinamide Impurity 127
  • 1005-24-9
  • Urinary excretion product of niacin metabolism
  • Pyridinium Compounds
  • Analytical Chromatography Product Catalog
  • Alphabetic
  • Analytical Standards
  • META - METH
  • Pyridinium Compounds