ChemicalBook > CAS DataBase List > 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

Product Name
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
CAS No.
1005-24-9
Chemical Name
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
Synonyms
1-METHYLNICOTINAMIDE CHLORIDE;TRIA-662;Trionellamide chloride;TRIGONELLAMIDE CHLORIDE;nicotinamidemethochloride;nipecotamidemethochloride;Nicotinamide Impurity 127;1-Methylnicotine Chloride;nicotinamidemethylchloride;NICOTINAMIDE CHLOROMETHYLATE
CBNumber
CB0431956
Molecular Formula
C7H9ClN2O
Formula Weight
172.61
MOL File
1005-24-9.mol
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3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Property

Melting point:
207-209℃ (water acetone )
storage temp. 
room temp
solubility 
H2O: soluble15mg/mL, clear
form 
crystalline
color 
white
Water Solubility 
almost transparency
Merck 
14,9693
CAS DataBase Reference
1005-24-9(CAS DataBase Reference)
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Safety

WGK Germany 
3
RTECS 
UU1925000
HS Code 
2933.39.9200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0704
Product name
1-Methylnicotinamide chloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$44.1
Updated
2024/03/01
Sigma-Aldrich
Product number
M4627
Product name
1-Methylnicotinamide chloride
Purity
analytical standard
Packaging
1g
Price
$180
Updated
2024/03/01
TCI Chemical
Product number
M0375
Product name
3-Carbamyl-1-methylpyridinium Chloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$239
Updated
2024/03/01
TCI Chemical
Product number
M0375
Product name
3-Carbamyl-1-methylpyridinium Chloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$695
Updated
2024/03/01
Cayman Chemical
Product number
16604
Product name
1-Methylnicotinamide (chloride)
Purity
≥95%
Packaging
100mg
Price
$32
Updated
2024/03/01
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3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Chemical Properties,Usage,Production

Description

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

Uses

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).

Uses

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

General Description

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Biochem/physiol Actions

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

Purification Methods

Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Suppliers

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View Lastest Price from 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000KG
Release date
2024-07-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-11

1005-24-9, 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDERelated Search:

1-Methylpyridinium chloride HS 6 3-(AMINOCARBONYL)-1-BENZYLPYRIDINIUM CHLORIDE 3-(AMINOCARBONYL)-1-(4-METHYLBENZYL)PYRIDINIUM CHLORIDE 3-(AMINOCARBONYL)-1-(4-CHLOROBENZYL)PYRIDINIUM CHLORIDE 2-ISOPROPYL-5-METHYLCYCLOHEXYL 2-(3-[(BENZYLAMINO)CARBONYL]PYRIDINIUM-1-YL)ACETATE CHLORIDE 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 3-CARBAMOYL-1-DODECYLOXYCARBONYLMETHYL-PYRIDINIUM CHLORIDE CORAMINEMETHOCHLORIDE

  • NICOTINAMIDE CHLOROMETHYLATE
  • N-METHYLNICOTINIC ACID AMIDE CHLORIDE SALT
  • N1-METHYLNICOTINAMIDE CHLORIDE
  • TRIGONELLAMIDE CHLORIDE
  • 3-(aminocarbonyl)-1-methyl-pyridiniuchloride
  • 3-carbamoyl-1-methyl-pyridiniuchloride
  • nicotinamidemethochloride
  • nicotinamidemethylchloride
  • 1-METHYLPYRIDINE-3-CARBOXYLIC ACID AMIDE CHLORIDE
  • 1-METHYLNICOTINAMIDE CHLORIDE
  • 1-METHYLNICOTINAMIDE CHLORIDE SALT
  • 3-CARBAMOYL-1-METHYLPYRIDINIUM CHLORIDE
  • 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
  • nipecotamidemethochloride
  • n-methylnicotinamidechloride
  • n-methylnicotinic acid amide chloride
  • 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 98+%
  • 3-Carbamoyl-1-methylpyridinium Chloride 1-Methylnicotinamide Chloride Nicotinamide Chloromethylate
  • 3-Carbamyl-1-methylpyridiniumChloride&gt
  • 1-methylpyridin-1-ium-3-carboxamide hydrochloride
  • Nicotinamide 1-Methyl Chloride
  • Trionellamide chloride
  • 3-Carbamoyl-1-methylpyridin-1-ium chloride
  • 2-ACETYL-5-CHLORO-40-METHYLTHIANAPHTHENE
  • TRIA-662
  • inhibit,1-Methylnicotinamide,N-methylnicotinamide,Inhibitor,Endogenous Metabolite,TRIA 662,anti-inflammatory activity,antithrombotic activity,HMECs,TRIA-662,TRIA662
  • Nicotinamide Impurity 127
  • 1-Methylnicotine Chloride
  • 1005-24-9
  • Urinary excretion product of niacin metabolism
  • Pyridinium Compounds
  • Analytical Chromatography Product Catalog
  • Alphabetic
  • Analytical Standards
  • META - METH
  • Pyridinium Compounds