3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

Product Name: 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
CAS No.: 1005-24-9
Chemical Name: 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
Synonyms: 1-METHYLNICOTINAMIDE CHLORIDE;TRIA-662;Trionellamide chloride;TRIGONELLAMIDE CHLORIDE;nicotinamidemethochloride;nipecotamidemethochloride;Nicotinamide Impurity 127;1-Methylnicotine Chloride;nicotinamidemethylchloride;NICOTINAMIDE CHLOROMETHYLATE
CBNumber: CB0431956
Molecular Formula: C7H9ClN2O
Formula Weight: 172.61
MOL File: 1005-24-9.mol

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3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Property

Melting point:: 207-209℃ (water acetone )
storage temp.: room temp
solubility: H2O: soluble15mg/mL, clear
form: crystalline
color: white
Water Solubility: almost transparency
Merck: 14,9693
CAS DataBase Reference: 1005-24-9(CAS DataBase Reference)

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Safety

WGK Germany: 3
RTECS: UU1925000
HS Code: 2933.39.9200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0704
Product name: 1-Methylnicotinamide chloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $44.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: M4627
Product name: 1-Methylnicotinamide chloride
Purity: analytical standard
Packaging: 1g
Price: $180
Updated: 2024/03/01

TCI Chemical

Product number: M0375
Product name: 3-Carbamyl-1-methylpyridinium Chloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $239
Updated: 2024/03/01

TCI Chemical

Product number: M0375
Product name: 3-Carbamyl-1-methylpyridinium Chloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $695
Updated: 2024/03/01

Cayman Chemical

Product number: 16604
Product name: 1-Methylnicotinamide (chloride)
Purity: ≥95%
Packaging: 100mg
Price: $32
Updated: 2024/03/01

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3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Chemical Properties,Usage,Production

Description

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

Uses

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).

Uses

Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.

General Description

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Biochem/physiol Actions

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT.

Purification Methods

Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE Suppliers

Americas 1 China 71 Europe 1 Germany 2 India 4 Japan 1 Switzerland 1 United Kingdom 4 United States 15 Global 100

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
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Energy Chemical

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Spectrum Chemical Manufacturing Corp.

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Shanghai Shenyue Chemical Co., Ltd.

Tel: 021-021-52212593 18049974220
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
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Country: China
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TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
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Email: Sales-JP@TCIchemicals.com
Country: Japan
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TCI Europe

Tel: 320-37350700
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Email: sales@tcieurope.eu
Country: Europe
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TCI AMERICA

Tel: 800-4238616
Fax: +1-888-520-1075 / +1-503-283-1987
Email: sales@tciamerica.com
Country: Americas
ProdList: 23653
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View Lastest Price from 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000KG
Release date: 2024-07-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 1005-24-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-11

1005-24-9, 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDERelated Search:

1-Methylpyridinium chloride HS 6 3-(AMINOCARBONYL)-1-BENZYLPYRIDINIUM CHLORIDE 3-(AMINOCARBONYL)-1-(4-METHYLBENZYL)PYRIDINIUM CHLORIDE 3-(AMINOCARBONYL)-1-(4-CHLOROBENZYL)PYRIDINIUM CHLORIDE 2-ISOPROPYL-5-METHYLCYCLOHEXYL 2-(3-[(BENZYLAMINO)CARBONYL]PYRIDINIUM-1-YL)ACETATE CHLORIDE 3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 3-CARBAMOYL-1-DODECYLOXYCARBONYLMETHYL-PYRIDINIUM CHLORIDE CORAMINEMETHOCHLORIDE

NICOTINAMIDE CHLOROMETHYLATE

N-METHYLNICOTINIC ACID AMIDE CHLORIDE SALT

N1-METHYLNICOTINAMIDE CHLORIDE

TRIGONELLAMIDE CHLORIDE

3-(aminocarbonyl)-1-methyl-pyridiniuchloride

3-carbamoyl-1-methyl-pyridiniuchloride

nicotinamidemethochloride

nicotinamidemethylchloride

1-METHYLPYRIDINE-3-CARBOXYLIC ACID AMIDE CHLORIDE

1-METHYLNICOTINAMIDE CHLORIDE

1-METHYLNICOTINAMIDE CHLORIDE SALT

3-CARBAMOYL-1-METHYLPYRIDINIUM CHLORIDE

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE

nipecotamidemethochloride

n-methylnicotinamidechloride

n-methylnicotinic acid amide chloride

3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE 98+%

3-Carbamoyl-1-methylpyridinium Chloride 1-Methylnicotinamide Chloride Nicotinamide Chloromethylate

3-Carbamyl-1-methylpyridiniumChloride&gt

1-methylpyridin-1-ium-3-carboxamide hydrochloride

Nicotinamide 1-Methyl Chloride

Trionellamide chloride

3-Carbamoyl-1-methylpyridin-1-ium chloride

2-ACETYL-5-CHLORO-40-METHYLTHIANAPHTHENE

TRIA-662

inhibit,1-Methylnicotinamide,N-methylnicotinamide,Inhibitor,Endogenous Metabolite,TRIA 662,anti-inflammatory activity,antithrombotic activity,HMECs,TRIA-662,TRIA662

Nicotinamide Impurity 127

1-Methylnicotine Chloride

1005-24-9

Urinary excretion product of niacin metabolism

Pyridinium Compounds

Analytical Chromatography Product Catalog

Alphabetic

Analytical Standards

META - METH

Pyridinium Compounds