ChemicalBook > CAS DataBase List > 3,4',5-TRIMETHOXY-TRANS-STILBENE

3,4',5-TRIMETHOXY-TRANS-STILBENE

Product Name
3,4',5-TRIMETHOXY-TRANS-STILBENE
CAS No.
22255-22-7
Chemical Name
3,4',5-TRIMETHOXY-TRANS-STILBENE
Synonyms
RP201772;RP 201772;RP-201772;TriMethoxystibene;Trimethoxystilbene;TRISMETHOXY RESVERATROL;Tri-O-methylresveratrol;Resveratrol three ether;Trimethoxy-trans-stilbene;3,4',5-Trimethoxystilbene
CBNumber
CB0446671
Molecular Formula
C17H18O3
Formula Weight
270.32
MOL File
22255-22-7.mol
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3,4',5-TRIMETHOXY-TRANS-STILBENE Property

Melting point:
57°C
Boiling point:
423.8±35.0 °C(Predicted)
Density 
1.104±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: ≥34mg/mL
form 
powder to crystal
color 
white to tan
InChI
InChI=1S/C17H18O3/c1-18-15-8-6-13(7-9-15)4-5-14-10-16(19-2)12-17(11-14)20-3/h4-12H,1-3H3/b5-4+
InChIKey
GDHNBPHYVRHYCC-SNAWJCMRSA-N
SMILES
C1(OC)=CC(/C=C/C2=CC=C(OC)C=C2)=CC(OC)=C1
CAS DataBase Reference
22255-22-7
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Safety

Hazard Codes 
Xi,N
Risk Statements 
36/37/38-50/53-41-37/38
Safety Statements 
26-36/37/39-61-60-39
RIDADR 
UN 3077 9 / PGIII
HS Code 
2909.30.6000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T1829
Product name
3,4',5-Trimethoxy-trans-stilbene
Purity
>98.0%(GC)
Packaging
5g
Price
$374
Updated
2025/07/31
Cayman Chemical
Product number
10188
Product name
trans-trismethoxy Resveratrol
Purity
≥98%
Packaging
50mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
10188
Product name
trans-trismethoxy Resveratrol
Purity
≥98%
Packaging
100mg
Price
$65
Updated
2024/03/01
Cayman Chemical
Product number
10188
Product name
trans-trismethoxy Resveratrol
Purity
≥98%
Packaging
250mg
Price
$134
Updated
2024/03/01
Cayman Chemical
Product number
10188
Product name
trans-trismethoxy Resveratrol
Purity
≥98%
Packaging
500mg
Price
$249
Updated
2024/03/01
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3,4',5-TRIMETHOXY-TRANS-STILBENE Chemical Properties,Usage,Production

Description

trans-trismethoxy Resveratrol is a polyketide synthase-derived stilbene originally isolated from Virola cuspidata that has diverse biological activities. It is cytotoxic to several cancer cell lines, including PC3, KB, HT-29, SW480, and HL-60 cells (IC50s =3.6, 10.2, 16.1, 54, and 2.5 μM, respectively). trans-trismethoxy Resveratrol (15 μM) inhibits TNF-α-induced activation of NF-κB in HEK293T cells in a reporter assay. It inhibits angiogenesis in zebrafish embryos when used at a concentration of 0.1 μM.

Chemical Properties

Pale Yellow Oil

Uses

A resveratrol analog with a variety of pharmacology action, including anti-cancer properties, anti-allergic activity, estrogenic activity, antiangiogenic activity, and vascular-targeting activity against microtubule-destabilization

Uses

A resveratrol analog with a variety of pharmacology action, including inst microtubule-destabilization

Uses

Phenolic compounds, particularly flavonoids, from plant sources have long been observed to have antioxidant activity with potential benefits for human health. Resveratrol is a potent phenolic antioxidant found in grapes and red wine that also has antiproliferative and anti-inflammatory activity. When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth and pro-apoptotic activities of resveratrol are enhanced.

References

[1] MICHAEL B. AUSTIN  Joseph P N. The Chalcone Synthase Superfamily of Type III Polyketide Synthases[J]. ChemInform, 2003, 34 17. DOI: 10.1002/chin.200317284
[2] FAHAD S ALDAWSARI  Carlos A V M. 3,4’,5-trans-Trimethoxystilbene; a natural analogue of resveratrol with enhanced anticancer potency.[J]. Investigational New Drugs, 2015, 33 3: 775-786. DOI: 10.1007/s10637-015-0222-x
[3] JUSTIN J. HEYNEKAMP. Substituted trans-Stilbenes, Including Analogues of the Natural Product Resveratrol, Inhibit the Human Tumor Necrosis Factor Alpha-Induced Activation of Transcription Factor Nuclear Factor KappaB[J]. Journal of Medicinal Chemistry, 2006, 49 24: 7182-7189. DOI: 10.1021/jm060630x
[4] MIRELLA BELLERI. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4’-trimethoxystilbene.[J]. Molecular Pharmacology, 2005, 67 5: 1451-1459. DOI: 10.1124/mol.104.009043

3,4',5-TRIMETHOXY-TRANS-STILBENE Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4',5-TRIMETHOXY-TRANS-STILBENE Suppliers

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View Lastest Price from 3,4',5-TRIMETHOXY-TRANS-STILBENE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
3,4',5-TRIMETHOXY-TRANS-STILBENE 22255-22-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-28
Shanghai Standard Technology Co., Ltd.
Product
3,4',5-Trimethoxy-trans-stilbene 22255-22-7
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-26
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
3,4',5-Trimethoxy-Trans-Stilbene 22255-22-7 22255-22-7
Price
US $24.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
1000.00 kgs
Release date
2019-07-19

22255-22-7, 3,4',5-TRIMETHOXY-TRANS-STILBENERelated Search:

Resveratrol trans Resveratrol 3-O-β-D-Glucuronide Resveratrol-3-4'-Disulfate Paclitaxel ISOLIQUIRITIN Chlorogenic acid 3-deoxysappanchalcone Costunolide Saikosaponin a alpha-(3,4-dihydroxyphenyl)lactic acid Dihydroresveratrol CIS-TRIMETHOXY STILBENE Oxyresveratrol trans/cis Resveratrol-D4 Azo-Resveratrol cis Resveratrol trans Resveratrol 4O-b-D-Glucuronide trans Resveratrol-3,5-disulfate

  • 3,4',5-TRIMETHOXY-TRANS-STILBENE
  • (E)-1,3-Dimethoxy-5-(4-methoxystyryl)benzene
  • (E)-3,4',5-Trimethoxystilbene
  • 3,5,4'-Trimethoxy-trans-stilbene
  • Trimethoxystilbene
  • 3,4,5-TRIMETHOXY-TRANS-STILBENE 95+%
  • TRANS-1-(3,5-DIMETHOXYPHENYL)-2-(4-METHOXYPHENYL)ETHYLENE
  • TRISMETHOXY RESVERATROL
  • 1,3-DIMETHOXY-5-[(E)-2-(4-METHOXY-PHENYL)-VINYL]-BENZENE
  • 1,3-DIMETHOXY-5-[(1E)-2-(4-METHOXYPHENYL)ETHENYL]-BENZENE
  • 1 (E)-5-[2-(4-HYDROXYPHENYL)ETHENYL]-1,3-BENZENE DIOL
  • trans-Trimethoxyresveratrol (trans-trismethoxy Resveratrol
  • Tri-O-methylresveratrol
  • trans-trismethoxy Resveratrol
  • E-Resveratrol TriMethyl Ether
  • TriMethoxystibene
  • trans-3,4',5-TriMethoxy-stilbene
  • B-0022 TrisMethoxyresveratrol
  • (E)-3,5,4'-Trimethoxystilbene
  • Benzene,1,3-diMethoxy-5-[(1E)-2-(4-Methoxyphenyl)ethenyl]-
  • 3,5,4'-TriMethoxy Stilbene
  • Resveratrol three ether
  • Trimethoxy-trans-stilbene
  • trans-Trimethoxyresveratrol
  • 3,4',5-Trimethoxy-Trans-Stilbene 22255-22-7
  • 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene
  • 5-TRIMETHOXY-TRANS-STILBENE
  • Resveratrol Trimethyl Ether Impurity
  • Resveratrol Impurity 28 (Resveratrol Trimethyl Ether ）
  • 22255-22-7 3,4',5-TRIMETHOXY-TRANS-STILBENE
  • RP 201772
  • RP201772
  • RP-201772
  • TRIMETHOXYSTILBENE, 3,5,4'-(TMS)
  • 3,4',5-Trimethoxy-trans-stilbene, ≥ 96.0%
  • trans-trismethoxy Resveratrol|||E-Resveratrol Trimethyl Ether|||MR-3|||Tri-O-methylresveratrol|||3,4',5-Trimethoxy-trans-stilbene|||Trimethoxystilbene
  • 3,4',5-Trimethoxystilbene
  • trans-Trimethoxyresveratrol, 10 mM in DMSO
  • 22255-22-7
  • Stilbenes
  • Resveratrol
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Stilbenes