ChemicalBook > CAS DataBase List > N-(4-iodophenyl)-5-nitrofuran-2-carboxamide

N-(4-iodophenyl)-5-nitrofuran-2-carboxamide

Product Name
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
CAS No.
314054-00-7
Chemical Name
N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
Synonyms
C-176;STING inhibitor 1;C-176 STING inhibitor;N-(4-iodophenyl)-5-nitro-2-furamide;N-(4-iodophenyl)-5-nitrofuran-2-carboxamide;2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-;STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
CBNumber
CB04522191
Molecular Formula
C11H7IN2O4
Formula Weight
358.09
MOL File
314054-00-7.mol
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N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Property

Boiling point:
361.2±37.0 °C(Predicted)
Density 
1.935±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in DMSO (up to 25 mg/ml)
pka
11.14±0.70(Predicted)
form 
solid
color 
Brown or yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2559
Product name
C-176
Purity
≥98% (HPLC)
Packaging
10mg
Price
$97.7
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2559
Product name
C-176
Purity
≥98% (HPLC)
Packaging
50mg
Price
$237
Updated
2024/03/01
Cayman Chemical
Product number
25859
Product name
C-176
Packaging
10mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
25859
Product name
C-176
Packaging
50mg
Price
$170
Updated
2024/03/01
Cayman Chemical
Product number
25859
Product name
C-176
Packaging
25mg
Price
$90
Updated
2024/03/01
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N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Chemical Properties,Usage,Production

Description

C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation?via?blockade of palmitoylation at Cys91. Treatment of Trex-/-?mice with C-176 resulted in a significant reduction in serum levels of Type I Interferons and amelioration of systemic inflammation.

storage

Store at -20°C

References

1)Haag?et al.?(2018),?Targeting STING with covalent small-molecule inhibitors; Nature?559?269

N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-iodophenyl)-5-nitrofuran-2-carboxamide Suppliers

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314054-00-7, N-(4-iodophenyl)-5-nitrofuran-2-carboxamideRelated Search:

TYRPHOSTIN AG 1296 Imatinib mesylate AG 490 Troglitazone

  • N-(4-iodophenyl)-5-nitrofuran-2-carboxamide
  • C-176
  • C-176 STING inhibitor
  • STING inhibitor 1
  • 2-Furancarboxamide, N-(4-iodophenyl)-5-nitro-
  • N-(4-iodophenyl)-5-nitro-2-furamide
  • STING,Stimulator of Interferon Genes,inhibit,MPYS,C-176,ERIS,C 176,TMEM173,Inhibitor,MITA
  • 314054-00-7