ChemicalBook > CAS DataBase List > 4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER

4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER

Product Name
4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER
CAS No.
211738-66-8
Chemical Name
4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER
Synonyms
AKOS B001423;ART-CHEM-BB B001423;RARECHEM AL BF 1005;methyl 4-bromo-1-methylpyrazole-3-carboxylate;methyl 4-bromo-1-methyl-pyrazole-3-carboxylate;Methyl 4-bromo-1-methyl-1H-pyrazol-3-carboxylate;methyl 4-bromo-1-methyl-1H-pyrazole-3-carboxylate;4-bromo-1-methyl-1H-pyrazole-3-methyl carboxylate;4-bromo-1-methyl-3-pyrazolecarboxylic acid methyl ester;4-bromo-1-methyl-pyrazole-3-carboxylic acid methyl ester
CBNumber
CB0453077
Molecular Formula
C6H7BrN2O2
Formula Weight
219.04
MOL File
211738-66-8.mol
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4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER Property

Boiling point:
276.5±20.0 °C(Predicted)
Density 
1.67±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-2.22±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M293813
Product name
Methyl4-Bromo-1-methyl-1H-pyrazole-3-carboxylate
Packaging
500mg
Price
$220
Updated
2021/12/16
TRC
Product number
M293813
Product name
Methyl4-Bromo-1-methyl-1H-pyrazole-3-carboxylate
Packaging
1g
Price
$330
Updated
2021/12/16
Matrix Scientific
Product number
062490
Product name
Methyl 4-bromo-1-methyl-1H-pyrazole-3-carboxylate
Packaging
500mg
Price
$315
Updated
2021/12/16
AK Scientific
Product number
Y8227
Product name
Methyl4-bromo-1-methyl-1H-pyrazole-3-carboxylate
Packaging
1g
Price
$191
Updated
2021/12/16
Apolloscientific
Product number
OR918037
Product name
Methyl4-bromo-1-methyl-1H-pyrazole-3-carboxylate
Purity
98%
Packaging
250mg
Price
$72
Updated
2021/12/16
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4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

81190-89-8

74-88-4

514816-42-3

211738-66-8

To a mixture of methyl 4-bromo-1H-pyrazole-3-carboxylate (15.0 g, 73.2 mmol) and Cs2CO3 (59.6 g, 182.9 mmol) in DMF (150 mL) was added slowly and dropwise at 0 °C under nitrogen protection iodomethane (14.7 mL, 236.0 mmol). The reaction mixture was stirred at 25 °C for 16 hours. After completion of the reaction, the mixture was filtered and the filter cake was washed with ethyl acetate (200 mL x 2). The combined filtrates were washed with water (70 mL x 4) and the aqueous phase was then back-extracted with ethyl acetate (150 mL). All organic phases were combined, dried with Na2SO4, filtered and concentrated to dryness under reduced pressure. The crude product was purified by fast column chromatography (gradient elution: petroleum ether/ethyl acetate from 100/0 to 50/50) to afford methyl 4-bromo-1-methyl-1H-pyrazole-3-carboxylate (240a, 8.3 g, 51.8% yield) and methyl 4-bromo-1-methyl-1H-pyrazole-5-carboxylate (240b, 7.0 g, 43.7% yield), both as white solid . 1H NMR (400 MHz, CDCl3) data for compound 240a: δ 7.48 (s, 1H), 4.15 (s, 3H), 3.93 (s, 3H). m/z (M + H) + 219.0 in MS (ESI).

References

[1] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 1197

4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER Suppliers

China 77 Germany 3 India 1 Russia 1 Switzerland 1 United Kingdom 2 United States 9 Global 94
Fluorochem Ltd
Tel
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Fax
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Email
vernam@fluorochem.co.uk
Country
United Kingdom
ProdList
6375
Advantage
65
Fluorochem Ltd.
Tel
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Fax
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Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
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View Lastest Price from 4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER manufacturers

Career Henan Chemical Co
Product
4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER 211738-66-8
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-08-07

211738-66-8, 4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTERRelated Search:

Methyl 4-broMo-1-Methyl-1H-iMidazole-2-carboxylate methyl 4-bromo-1-methyl-1H-pyrazole-5-carboxylate ethyl 4-broMo-1-Methyl-1H-pyrazole-3-carboxylate methyl 1-methyl-1H-pyrazole-5-carboxylate Ethyl 4-Chloro-1-Methyl-1H-Pyrazole-3-Carboxylate methyl 1-methyl-1H-pyrazole-3-carboxylate 1H-Pyrazole-3-carboxylicacid,1-methyl-,ethylester(9CI) 4-BROMO-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID 1-Methyl-1H-pyrazole-3-carboxylic acid

  • RARECHEM AL BF 1005
  • ART-CHEM-BB B001423
  • 4-BROMO-1-METHYL-1 H-PYRAZOLE-3-CARBOXYLIC ACID M ETHYL ESTER
  • AKOS B001423
  • methyl 4-bromo-1-methyl-1H-pyrazole-3-carboxylate
  • 1H-pyrazole-3-carboxylic acid, 4-bromo-1-methyl-, methyl e
  • methyl 4-bromo-1-methyl-1H-pyrazole-3-carboxylate(SALTDATA: FREE)
  • 4-bromo-1-methyl-3-pyrazolecarboxylic acid methyl ester
  • 4-bromo-1-methyl-pyrazole-3-carboxylic acid methyl ester
  • methyl 4-bromo-1-methyl-pyrazole-3-carboxylate
  • methyl 4-bromo-1-methylpyrazole-3-carboxylate
  • Pyrazole-3-carboxylic acid, 4-bromo-1-methyl-, methyl ester
  • 4-BROMO-1-METHYLXYLIC ACID M ETHYL ESTER-1 H-PYRAZOLE-3-CARBO
  • 1H-Pyrazole-3-carboxylic acid, 4-bromo-1-methyl-, methyl ester
  • 1H-Pyrazole-3-carboxylic acid, 4-bromo-1-methyl-, methyl ester (9CI, ACI)
  • 4-bromo-1-methyl-1H-Pyrazole-3-carboxylic acid methyl ester (9CI ACI)
  • 4-Bromo-1-methyl-1H-pyrazol-3-carboxylic acid methyl ester
  • 4-bromo-1-methyl-1H-pyrazole-3-methyl carboxylate
  • Methyl 4-bromo-1-methyl-1H-pyrazol-3-carboxylate
  • 211738-66-8