methyl 1-methyl-1H-pyrazole-5-carboxylate
- Product Name
- methyl 1-methyl-1H-pyrazole-5-carboxylate
- CAS No.
- 17827-60-0
- Chemical Name
- methyl 1-methyl-1H-pyrazole-5-carboxylate
- Synonyms
- Methyl 1-methylpyrazole-5-carboxylate;Methyl 2-Methylpyrazole-3-carboxylate;Methyl 1-methyl-1H-pyrazol-5-carboxylate;methyl 1-methyl-1H-pyrazole-5-carboxylate;2-methylpyrazole-3-carboxylic acid methyl ester;2-methyl-3-pyrazolecarboxylic acid methyl ester;Pyrazole-5-carboxylic acid, 1-Methyl-, Methyl ester;1H-Pyrazole-5-carboxylic acid, 1-Methyl-, Methyl ester;2-Methyl-2H-Pyrazole-3-Carboxylic Acid Methyl Ester(WX618160)
- CBNumber
- CB32522884
- Molecular Formula
- C6H8N2O2
- Formula Weight
- 140.14
- MOL File
- 17827-60-0.mol
methyl 1-methyl-1H-pyrazole-5-carboxylate Property
- Boiling point:
- 83-84 °C(Press: 12 Torr)
- Density
- 1.18±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 0.47±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C6H8N2O2/c1-8-5(3-4-7-8)6(9)10-2/h3-4H,1-2H3
- InChIKey
- CECCPWAWRYFLOA-UHFFFAOYSA-N
- SMILES
- N1(C)C(C(OC)=O)=CC=N1
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M338415
- Product name
- Methyl1-Methyl-1H-pyrazole-5-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H58-1-VJ
- Product name
- Methyl 1-methyl-1H-pyrazole-5-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0037113
- Product name
- Methyl1-methyl-1H-pyrazole-5-carboxylate
- Purity
- 99.39%
- Packaging
- 10g
- Price
- $92
- Updated
- 2021/12/16
- Product number
- CS-0037113
- Product name
- Methyl1-methyl-1H-pyrazole-5-carboxylate
- Purity
- 99.39%
- Packaging
- 5g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- OR910254
- Product name
- Methyl2-methylpyrazole-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
methyl 1-methyl-1H-pyrazole-5-carboxylate Chemical Properties,Usage,Production
Synthesis
67-56-1
16034-46-1
17827-60-0
Under argon protection, 1-methyl-1H-pyrazole-5-carboxylic acid (5 g, 39.7 mmol) was dissolved in methanol (100 mL) and cooled to 0 °C. Thionyl chloride (103.2 mmol) was slowly added dropwise, keeping the reaction temperature at 0 °C. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirred continuously for 12 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The concentrate was diluted with water (100 mL) and centrifuged with saturated aqueous sodium bicarbonate solution to pH neutral. Subsequently, extraction was performed with ethyl acetate (100 mL x 3). The organic phases were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give methyl 1-methyl-1H-pyrazole-5-carboxylate as a white solid in 90% yield (5 g) with a mass m/z of 240, which did not require further purification.
References
[1] Patent: WO2014/151142, 2014, A1. Location in patent: Paragraph 0092
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1980, vol. 29, # 5, p. 778 - 784
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1980, # 5, p. 1071 - 1077
methyl 1-methyl-1H-pyrazole-5-carboxylate Preparation Products And Raw materials
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View Lastest Price from methyl 1-methyl-1H-pyrazole-5-carboxylate manufacturers
- Product
- methyl 1-methyl-1H-pyrazole-5-carboxylate 17827-60-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-07