L-Epicatechin

Product Name: L-Epicatechin
CAS No.: 490-46-0
Chemical Name: L-Epicatechin
Synonyms: EPICATECHIN;(-)-EPICATECHIN;Epicatechine;EPICATECHIN, (-)-;(2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL;Kakaol;(-)-EC;(+)-EC;Colatein;NSC 81161
CBNumber: CB0454852
Molecular Formula: C15H14O6
Formula Weight: 290.27
MOL File: 490-46-0.mol

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L-Epicatechin Property

Melting point:: 240 °C (dec.)(lit.)
alpha: -55～-65゜(D/20℃)(c=1,CH3OH)
Boiling point:: 629.2 °C
Density: 1.593±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥14.5 mg/mL in DMSO
form: Solid
pka: 9.54±0.10(Predicted)
color: White to Light yellow to Light orange
Water Solubility: Soluble in water or alcohol
Merck: 13,1912
BRN: 92760
Stability:: Hygroscopic
InChIKey: PFTAWBLQPZVEMU-UKRRQHHQSA-N
LogP: 0.490 (est)
CAS DataBase Reference: 490-46-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: KB3745000
F: 10-23
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 68097
Product name: (?)-Epicatechin
Purity: analytical standard
Packaging: 10mg
Price: $467
Updated: 2024/03/01

Sigma-Aldrich

Product number: 03940590
Product name: Epicatechin
Purity: primary reference standard
Packaging: 10mg
Price: $466
Updated: 2024/03/01

TCI Chemical

Product number: E1226
Product name: (-)-Epicatechin
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $136
Updated: 2024/03/01

TCI Chemical

Product number: E1226
Product name: (-)-Epicatechin
Purity: >97.0%(HPLC)
Packaging: 5g
Price: $406
Updated: 2024/03/01

Alfa Aesar

Product number: J61218
Product name: (-)-Epicatechin
Packaging: 20mg
Price: $404.65
Updated: 2024/03/01

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L-Epicatechin Chemical Properties,Usage,Production

Description

(−)-Epicatechin is a polyketide synthase-derived polyphenol flavonoid that has been found in T. cacao and has diverse biological activities. It scavenges DPPH radicals in a cell-free assay when used at a concentration of 5 μM. (−)-Epicatechin inhibits COX-1 (IC₅₀ = 3.2 μM). It acts synergistically with epigallocatechin gallate to induce apoptosis in, and reduce the proliferation of, PC-9 lung cancer cells when used at a concentration of 200 μM. (−)-Epicatechin (80 mg/kg) reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation.

Chemical Properties

white to light yellow crystal powde

Uses

Potent antioxidant and antineoplastic agent.

Uses

Catechin is a polyphenolic flavonoid that has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro lipid peroxidation assays. (?)-Epicatechin is a 2R,3R stereoisomer of catechin. Like catechin, (?)-epicatechin is a powerful antioxidant. It inhibits cyclooxygenase 1 (IC50 = 3.2 μM). Also, at 100 μM, (?)-epicatechin induces apoptosis in human adenocarcinoma PC-9 cells and stimulates the inhibition of tumor necrosis factor-α release from BALB-c/3T3 cells treated with epigallocatechin gallate.

Uses

An antioxidant and natural product from green tea

Definition

ChEBI: A catechin with (2R,3R)-configuration.

General Description

(?)-Epicatechin (EC) belongs to the group of flavanols and is abundantly present in cacao and cacao products. The chemical structure of EC includes an oxygenated heterocycle with a 4-hydroxyl group linked with two aromatic rings.

Biochem/physiol Actions

This antioxidant is found in chocolate. (-)-Epicatechin is linked with cardiovascular effects. It is considered as a dependable standard due to its availability in cacao seeds and cocoa products. The halogenating activity of myeloperoxidase can be restored by (-)-epicatechin.

References

[1]. chakravarthy bk, gupta s, gambhir ss, et al. pancreatic beta-cell regeneration in rats by (-)-epicatechin. lancet, 1981, 2(8249): 759-760.
[2]. wippel r, rehn m, gorren ac, et al. interference of the polyphenol epicatechin with the biological chemistry of nitric oxide- and peroxynitrite-mediated reactions. biochem pharmacol, 2004, 67(7): 1285-1295.
[3]. brossette t, hundsdörfer c, kröncke kd, et al. direct evidence that (-)-epicatechin increases nitric oxide levels in human endothelial cells. eur j nutr, 2011, 50(7): 595-599.
[4]. okushio k, suzuki m, matsumoto n, et al. identification of (-)-epicatechin metabolites and their metabolic fate in the rat. drug metab dispos, 1999, 27(2): 309-316.

L-Epicatechin Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Epicatechin Suppliers

Americas 1 Canada 2 China 416 Czech Republic 1 Europe 4 France 2 Germany 6 India 8 Japan 3 Poland 1 Switzerland 2 United Kingdom 7 United States 43 Global 496

Nanjing Duolong Bio-tech Co.,Ltd.

Tel: 18905173768
Fax: 025-83263139
Email: sales@dolonchem.com
Country: China
ProdList: 2331
Advantage: 50

Nanjing Digger Medical Technology Co. Ltd.

Tel: 025-025-51191215 18013836722
Fax: 025-51191215
Email: 2399235533@qq.com
Country: China
ProdList: 4933
Advantage: 58

Shaanxi Pioneer Biotech Co., Ltd.

Tel: 029-029-86629612 18202932191
Email: sales3@pioneerbiotech.com
Country: China
ProdList: 336
Advantage: 55

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Tel: 025-84430028 13815430202
Email: sale02@cqherb.com
Country: China
ProdList: 281
Advantage: 59

Chengdu Wuyuan Bioengineering Co., Ltd.

Tel: 17358513851
Email: henry851@163.com
Country: China
ProdList: 955
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
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View Lastest Price from L-Epicatechin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: L-Epicatechin 490-46-0
Price: US $62.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-05-24

Changsha Staherb Natural Ingredients Co., Ltd.

Product: L-Epicatechin; Green tea extract 490-46-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 1000KG
Release date: 2022-09-27

Wuhan Haorong Biotechnology Co.,Ltd

Product: L-Epicatechin 490-46-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000
Release date: 2023-08-11

490-46-0, L-Epicatechin Related Search:

Centchroman (-)-Epicatechin gallate Triphenylphosphine Dihydromyrcenol Cianidanol Hydroxy silicone oil Tetrahydro-4H-pyran-4-one 2-Phenylphenol Procyanidin B1 Phenylacetone (-)-EPICATECHIN PROCYANIDIN B2 (-)-Epicatechin-pentaacetate,(-)-Epicatechin-pentaacetate,(-)-Epicatechin-pentaacetate L-Epicatechin Gallocatechin-（4α→8）epicatechin,Gallocatechin-（4α→8）epicatechin,Gallocatechin-（4α→8）epicatechin Epigallocatechin-(4β→8)-epicatechin-3-O-gallate ester (-)-Epicatechin-3-O-gallate Galloylepicatechin,(-)-Epicatechin-3-O-gallate Galloylepicatechin,(-)-Epicatechin-3-O-gallate Galloylepicatechin (-)-EPICATECHIN 3-(4''-O-METHYL)GALLATE,(-)-EPICATECHIN 3-(4''-O-METHYL)GALLATE,(-)-EPICATECHIN 3-(4''-O-METHYL)GALLATE

3,3',4',5,7-PENTAHYDROXY-FLAVANE

3,3',4',5,7-PENTAHYROXYFLAVONE

3,3',4',5,7-PENTAHYDROXYFLAVAN

(2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL

(-)-epicatecho

(-)-epicatechol

(-)-EPICATECHIN

(+)-EPICATECHIN

EPICATECHIN

EPICATECHIN, (-)-

EPICATECHIN, (+)-

CIS-2-[3,4-DIHYDROXYPHENYL]-3,4-DIHYDRO-2H-1-BENZOPYRAN-3,5,7-TRIOL

(-)-CIS-3,3',4',5,7-PENTAHYDROXYFLAVANE

CIS-3,3',4',5,7-PENTAHYDROXYFLAVANE

L-(-)-EPICATECHIN

L-EPICATECHIN

(-)-3,5,7,3',4'-PENTAHYDROXYFLAVAN

3,5,7,3',4'-PENTAHYDROXYFLAVAN

(-)-Epicatechin (EC)

1-EPICATECHIN

GREENTEAEPICATECHIN

EpicatechinEpicatechol

2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol

(-)-EPICATECHIN CRYSTALLINE,98%

(-)EPICATECHIN WITH HPLC

(3,4-dihydroxyphenyl)-3,4-dihydro-,(2R-cis)-

2H-1-Benzopyran-3,5,7-triol, 2-

(-)-cis-3,3μ,4μ,5,7-Pentahydroxyflavane, (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol

L-Epicatechin，EC

2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R-cis)-

(2R)-2α-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3α,5,7-triol

[2R,(-)]-2α-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3α,5,7-triol

L(-)-Epicatechin,99+%

L(-)-Epicatechin, mixt. of ca. 60% L(-)-Epicatechin and ca. 40% Catechin

()-Epicatechin,()-cis-3,3′,4′,5,7-Pentahydroxyflavane, (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol

(-)-EPICATECHIN(2-8℃)

(-)-EPICATECIN

(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol

Acacatechin

Colatein

Kakaol

Teacatechin I

NSC 81161

L-Epicatechin 490-46-0

Epicatechine

(-)-EPICATECHIN GREEN TEA

(-)-EPICATECHIN CRYSTALLINE

2-(3,4-dihydroxyphenyl)-2,3,4-trihydro-3,5,7-trihydroxychromene

(2R,3R)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol

2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-cis)-2h-1-benzopyran-7-triol

epicatechol

epi-catechol

l-acacatechin

l-epicatechol

L-Epicatechin 2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol

Table son tea

EC, L-Epicatechin

(-)-Epicatechin, >=98%