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Procyanidin B1

Product Name
Procyanidin B1
CAS No.
20315-25-7
Chemical Name
Procyanidin B1
Synonyms
Proanthocyanidin B1;Procyanidin B1, 97%, from Vitis vinifera Linn.;OligoMeric Proantho Cyanidins;PROCYANIDIN B1;Procyanidin B1-RM;PROCYANIDIN A2(SH);PROCYANIDIN B1(RG);PROCYANIDINDIMERB1;(4→8)-Procyanidin B1;Procyanidin Impurity 2
CBNumber
CB3753343
Molecular Formula
C30H26O12
Formula Weight
578.52
MOL File
20315-25-7.mol
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Procyanidin B1 Property

Melting point:
231～232℃
Boiling point:
955.3±65.0 °C(Predicted)
Density 
1.705±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Acetone (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
pka
9.29±0.60(Predicted)
form 
Solid
color 
Pale Brown
InChIKey
XFZJEEAOWLFHDH-UKWJTHFESA-N
SMILES
[C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2[C@H](C2=C3O[C@H](C4=CC=C(O)C(O)=C4)[C@@H](O)CC3=C(O)C=C2O)[C@H]1O
LogP
0.300 (est)
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Safety

Safety Statements 
24/25
WGK Germany 
3
F 
10-23
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHL89764
Product name
Procyanidin B1
Purity
phyproof? Reference Substance
Packaging
5MG
Price
$414
Updated
2025/07/31
Sigma-Aldrich
Product number
19542
Product name
Procyanidin B1
Purity
analytical standard
Packaging
1mg
Price
$590
Updated
2025/07/31
Cayman Chemical
Product number
22411
Product name
Procyanidin B1
Purity
≥98%
Packaging
1mg
Price
$59
Updated
2024/03/01
Cayman Chemical
Product number
22411
Product name
Procyanidin B1
Purity
≥98%
Packaging
5mg
Price
$239
Updated
2024/03/01
Cayman Chemical
Product number
22411
Product name
Procyanidin B1
Purity
≥98%
Packaging
10mg
Price
$448
Updated
2024/03/01
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Procyanidin B1 Chemical Properties,Usage,Production

Description

Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin and (−)-epicatechin . It inhibits hepatitis C virus RNA replication (EC50 = 72 μM), while (+)-catechin and (−)-epicatechin do not, up to concentrations of 200 μM. Procyanidin B1 (10 μg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells. It decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels following LPS administration.

Chemical Properties

Pale yellow powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from grape seeds.

Uses

Procyanidins B1 is a B type proanthocyanidins found in ceylon cinnamon and is known to exhibit anti-inflammatory effects.

Definition

ChEBI: Procyanidin B1 is a proanthocyanidin consisting of (-)-epicatechin and (+)-catechin units joined by a bond between positions 4 and 8' respectively in a beta-configuration.. Procyanidin B1 can be found in Cinnamomum verum (Ceylon cinnamon, in the rind, bark or cortex), in Uncaria guianensis (cat's claw, in the root), and in Vitis vinifera (common grape vine, in the leaf) or in peach. It has a role as a metabolite, an EC 3.4.21.5 (thrombin) inhibitor and an anti-inflammatory agent. It is a hydroxyflavan, a proanthocyanidin, a biflavonoid and a polyphenol. It is functionally related to a (-)-epicatechin and a (+)-catechin.

References

[1] SHENWEI LI. Procyanidin B1 purified from Cinnamomi cortex suppresses hepatitis C virus replication.[J]. Antiviral Chemistry and Chemotherapy, 2010, 20 6: 239-248. DOI: 10.3851/imp1597
[2] X TERRA. Procyanidin dimer B1 and trimer C1 impair inflammatory response signalling in human monocytes.[J]. Free Radical Research, 2011, 45 5: 611-619. DOI: 10.3109/10715762.2011.564165
[3] JING XING. Anti-inflammatory effect of procyanidin B1 on LPS-treated THP1 cells via interaction with the TLR4-MD-2 heterodimer and p38 MAPK and NF-κB signaling.[J]. Molecular and Cellular Biochemistry, 2015, 407 1-2: 89-95. DOI: 10.1007/s11010-015-2457-4

Procyanidin B1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Procyanidin B1 Suppliers

Canada 1 China 238 France 1 Germany 4 India 1 Japan 1 Switzerland 1 United Kingdom 4 United States 17 USA 1 Global 269
Chengdu Gupte Biotechnology Co., Ltd.
Tel
13881890404
Fax
028-81711798
Email
2851503757@qq.com
Country
China
ProdList
2283
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58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
18108052721
Email
2850505130@qq.com
Country
China
ProdList
5167
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58
Hubei CuiRan Biotechnology Co., Ltd.
Tel
00-1816279-5156 18162795156
Email
3391961471@qq.com
Country
China
ProdList
4332
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
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61
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
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57
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
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58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
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60
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View Lastest Price from Procyanidin B1 manufacturers

Nanjing Deda New Material Technology Ltd.
Product
Procyanidin B1 20315-25-7
Price
US $10.00-30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100ton/ month
Release date
2024-04-12
Shanghai Standard Technology Co., Ltd.
Product
Procyanidin B1 20315-25-7
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-02-17
Career Henan Chemical Co
Product
PROCYANIDIN B1 20315-25-7
Price
US $1.00/kg
Min. Order
1 mg
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

20315-25-7, Procyanidin B1Related Search:

PROCYANIDIN B2,PROCYANIDIN B2(RG),(4→8)-Procyanidin B2 PROCYANIDIN C1 PROCYANIDIN A2 PROCYANIDIN B3,procyanidin B3 from barley 2-(3,4-Dihydroxyphenyl)-2-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl)oxy)chroman-3,4,5,7-tetraol Protodioscin Laurus nobilis, ext. Protopanaxatriol Procyanidin VIRGINIAMYCIN M1 Pristinamycin IA (7S)-3,7,10,11-Tetrahydroxy-7,8-dihydro-6H-dibenzo[b,d]oxocin-7-methanol Protocatechuic acid Protocatechualdehyde [(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-4-[(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyl)oxy-chroman-8-yl]-5,7-dihydroxy-chroman-3-yl] 3,4,5-trihydroxybenzoate Prodelphinidin T4 Procyanidin B2 3-gallate (4→6)-Procyanidin B5

  • Procyanidin B1, 97%, from Vitis vinifera Linn.
  • Procyanidin B1 [Epicatechin (4β→8) catechin]
  • PROCYANIDIN B1
  • CIS,TRANS''-4,8''-BI-(3,3',4',5,7-PENTAHYDROXYFLAVANE)
  • EPICATECHIN(4B-8)CATECHIN
  • EPICATECHIN(4BETA->8)CATECHIN
  • (2R,2'R,3R,3'S,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-4,8'-bichroman-3,3',5,5',7,7'-hexol
  • (2R,2'R,3R,3'S,4β)-3,3',4,4'-Tetrahydro-2α,2'α-bis(3,4-dihydroxyphenyl)-4,8'-bi[2H-1-benzopyran]-3,3',5,5',7,7'-hexol
  • (2R,3R,4R,2'R,3'S)-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-4,8'-bi(2H-1-benzopyran)-3,3',5,5',7,7'-hexol
  • (4→8)-Procyanidin B1
  • Proanthocyanidin B1
  • 2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
  • 2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-8-yl]chromane-3,5,7-triol
  • PROCYANIDIN A2(SH)
  • Procyanidin B1,cis,trans′′-4,8′′-Bi-(3,3′,4′,5,7-Pentahydroxyflavane)
  • 2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol
  • PROCYANIDIN B1(RG)
  • PROCYANIDINDIMERB1
  • OligoMeric Proantho Cyanidins
  • Procyanidin B1, froM Vitis vinifera Linn.
  • Procyanidin Impurity 2
  • [4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'S,4R)-
  • PROCYANIDIN B1 USP/EP/BP
  • (2R,2'R,3R,3'S,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-[4,8'-bichromane]-3,3',5,5',7,7'-hexaol
  • Procyanidin B1-RM
  • Procyanidin B1, 10 mM in DMSO
  • 20315-25-7
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