ChemicalBook > CAS DataBase List > Procyanidin B1

Procyanidin B1

Product Name: Procyanidin B1
CAS No.: 20315-25-7
Chemical Name: Procyanidin B1
Synonyms: Proanthocyanidin B1;Procyanidin B1, 97%, from Vitis vinifera Linn.;OligoMeric Proantho Cyanidins;PROCYANIDIN B1;Procyanidin B1-RM;PROCYANIDIN A2(SH);PROCYANIDIN B1(RG);PROCYANIDINDIMERB1;(4→8)-Procyanidin B1;Procyanidin Impurity 2
CBNumber: CB3753343
Molecular Formula: C30H26O12
Formula Weight: 578.52
MOL File: 20315-25-7.mol

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Procyanidin B1 Property

Melting point:: 231～232℃
Boiling point:: 955.3±65.0 °C(Predicted)
Density: 1.705±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Acetone (Slightly), Ethanol (Slightly), Methanol (Slightly), Water (Slightly)
pka: 9.29±0.60(Predicted)
form: Solid
color: Pale Brown
InChIKey: XFZJEEAOWLFHDH-UKWJTHFESA-N
SMILES: [C@H]1(C2=CC=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2[C@H](C2=C3O[C@H](C4=CC=C(O)C(O)=C4)[C@@H](O)CC3=C(O)C=C2O)[C@H]1O
LogP: 0.300 (est)

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Safety

Safety Statements: 24/25
WGK Germany: 3
F: 10-23
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89764
Product name: Procyanidin B1
Purity: phyproof? Reference Substance
Packaging: 5MG
Price: $414
Updated: 2025/07/31

Sigma-Aldrich

Product number: 19542
Product name: Procyanidin B1
Purity: analytical standard
Packaging: 1mg
Price: $590
Updated: 2025/07/31

Cayman Chemical

Product number: 22411
Product name: Procyanidin B1
Purity: ≥98%
Packaging: 1mg
Price: $59
Updated: 2024/03/01

Cayman Chemical

Product number: 22411
Product name: Procyanidin B1
Purity: ≥98%
Packaging: 5mg
Price: $239
Updated: 2024/03/01

Cayman Chemical

Product number: 22411
Product name: Procyanidin B1
Purity: ≥98%
Packaging: 10mg
Price: $448
Updated: 2024/03/01

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Procyanidin B1 Chemical Properties,Usage,Production

Description

Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin and (−)-epicatechin . It inhibits hepatitis C virus RNA replication (EC₅₀ = 72 μM), while (+)-catechin and (−)-epicatechin do not, up to concentrations of 200 μM. Procyanidin B1 (10 μg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells. It decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels following LPS administration.

Chemical Properties

Pale yellow powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from grape seeds.

Uses

Procyanidins B1 is a B type proanthocyanidins found in ceylon cinnamon and is known to exhibit anti-inflammatory effects.

Definition

ChEBI: Procyanidin B1 is a proanthocyanidin consisting of (-)-epicatechin and (+)-catechin units joined by a bond between positions 4 and 8' respectively in a beta-configuration.. Procyanidin B1 can be found in Cinnamomum verum (Ceylon cinnamon, in the rind, bark or cortex), in Uncaria guianensis (cat's claw, in the root), and in Vitis vinifera (common grape vine, in the leaf) or in peach. It has a role as a metabolite, an EC 3.4.21.5 (thrombin) inhibitor and an anti-inflammatory agent. It is a hydroxyflavan, a proanthocyanidin, a biflavonoid and a polyphenol. It is functionally related to a (-)-epicatechin and a (+)-catechin.

References

[1] SHENWEI LI. Procyanidin B1 purified from Cinnamomi cortex suppresses hepatitis C virus replication.[J]. Antiviral Chemistry and Chemotherapy, 2010, 20 6: 239-248. DOI: 10.3851/imp1597
[2] X TERRA. Procyanidin dimer B1 and trimer C1 impair inflammatory response signalling in human monocytes.[J]. Free Radical Research, 2011, 45 5: 611-619. DOI: 10.3109/10715762.2011.564165
[3] JING XING. Anti-inflammatory effect of procyanidin B1 on LPS-treated THP1 cells via interaction with the TLR4-MD-2 heterodimer and p38 MAPK and NF-κB signaling.[J]. Molecular and Cellular Biochemistry, 2015, 407 1-2: 89-95. DOI: 10.1007/s11010-015-2457-4

Procyanidin B1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Procyanidin B1 manufacturers

Nanjing Deda New Material Technology Ltd.

Product: Procyanidin B1 20315-25-7
Price: US $10.00-30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100ton/ month
Release date: 2024-04-12

Shanghai Standard Technology Co., Ltd.

Product: Procyanidin B1 20315-25-7
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-02-17

Career Henan Chemical Co

Product: PROCYANIDIN B1 20315-25-7
Price: US $1.00/kg
Min. Order: 1 mg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-25

20315-25-7, Procyanidin B1Related Search:

PROCYANIDIN B2,PROCYANIDIN B2(RG),(4→8)-Procyanidin B2 PROCYANIDIN C1 PROCYANIDIN A2 PROCYANIDIN B3,procyanidin B3 from barley 2-(3,4-Dihydroxyphenyl)-2-((2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl)oxy)chroman-3,4,5,7-tetraol Protodioscin Laurus nobilis, ext. Protopanaxatriol Procyanidin VIRGINIAMYCIN M1 Pristinamycin IA (7S)-3,7,10,11-Tetrahydroxy-7,8-dihydro-6H-dibenzo[b,d]oxocin-7-methanol Protocatechuic acid Protocatechualdehyde [(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-4-[(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3,4,5-trihydroxybenzoyl)oxy-chroman-8-yl]-5,7-dihydroxy-chroman-3-yl] 3,4,5-trihydroxybenzoate Prodelphinidin T4 Procyanidin B2 3-gallate (4→6)-Procyanidin B5

Procyanidin B1, 97%, from Vitis vinifera Linn.

Procyanidin B1 [Epicatechin (4β→8) catechin]

PROCYANIDIN B1

CIS,TRANS''-4,8''-BI-(3,3',4',5,7-PENTAHYDROXYFLAVANE)

EPICATECHIN(4B-8)CATECHIN

EPICATECHIN(4BETA->8)CATECHIN

(2R,2'R,3R,3'S,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-4,8'-bichroman-3,3',5,5',7,7'-hexol

(2R,2'R,3R,3'S,4β)-3,3',4,4'-Tetrahydro-2α,2'α-bis(3,4-dihydroxyphenyl)-4,8'-bi[2H-1-benzopyran]-3,3',5,5',7,7'-hexol

(2R,3R,4R,2'R,3'S)-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-4,8'-bi(2H-1-benzopyran)-3,3',5,5',7,7'-hexol

(4→8)-Procyanidin B1

Proanthocyanidin B1

2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-3,4-dihydro-2H-chromene-3,5,7-triol

2-(3,4-dihydroxyphenyl)-4-[2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-chroman-8-yl]chromane-3,5,7-triol

PROCYANIDIN A2(SH)

Procyanidin B1,cis,trans′′-4,8′′-Bi-(3,3′,4′,5,7-Pentahydroxyflavane)

2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-2H,2'H-4,8'-bichromene-3,3',5,5',7,7'-hexol

PROCYANIDIN B1(RG)

PROCYANIDINDIMERB1

OligoMeric Proantho Cyanidins

Procyanidin B1, froM Vitis vinifera Linn.

Procyanidin Impurity 2

[4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'S,4R)-

PROCYANIDIN B1 USP/EP/BP

(2R,2'R,3R,3'S,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-[4,8'-bichromane]-3,3',5,5',7,7'-hexaol

Procyanidin B1-RM

Procyanidin B1, 10 mM in DMSO

20315-25-7

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