ChemicalBook > CAS DataBase List > 4-Iodopyrazole

4-Iodopyrazole

Product Name
4-Iodopyrazole
CAS No.
3469-69-0
Chemical Name
4-Iodopyrazole
Synonyms
4-IODO-1H-PYRAZOLE;4-IODOPYRAZOLE;4-Lodophrazole;4-LODO PYRAZOLE;4-iodopyrazole 4-;4-Iodopyrazole>4-IODOPYRAZOLE 99%;4-Iodopyrazole ,98%;4 - iodine pyrazole;4-Iodopyrazole, 97+%
CBNumber
CB0456472
Molecular Formula
C3H3IN2
Formula Weight
193.97
MOL File
3469-69-0.mol
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4-Iodopyrazole Property

Melting point:
108-110 °C (lit.)
Boiling point:
291.9±13.0 °C(Predicted)
Density 
2.335±0.06 g/cm3(Predicted)
RTECS 
UQ7145000
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
12.99±0.50(Predicted)
form 
Crystalline Powder
color 
White to off-white
Water Solubility 
Soluble in water.
Sensitive 
Light Sensitive
InChI
InChI=1S/C3H3IN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6)
InChIKey
LLNQWPTUJJYTTE-UHFFFAOYSA-N
SMILES
N1C=C(I)C=N1
CAS DataBase Reference
3469-69-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29331990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
213993
Product name
4-Iodopyrazole
Purity
99%
Packaging
10g
Price
$91.3
Updated
2025/07/31
TCI Chemical
Product number
I0692
Product name
4-Iodopyrazole
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$41
Updated
2025/07/31
TCI Chemical
Product number
I0692
Product name
4-Iodopyrazole
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$186
Updated
2025/07/31
TRC
Product number
I719470
Product name
4-Iodopyrazole
Packaging
100g
Price
$745
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
Y15229
Product name
4-Iodopyrazole
Purity
98%
Packaging
5g
Price
$5
Updated
2021/12/16
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4-Iodopyrazole Chemical Properties,Usage,Production

Chemical Properties

White or off-white solid

Uses

4-Iodopyrazole is used in the synthesis of (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met.

Uses

4-Iodopyrazole was used in an indium-mediated synthesis of heterobiaryls.

Definition

ChEBI: 4-iodopyrazole is a member of pyrazoles and an organoiodine compound.

General Description

4-Iodopyrazole is a valuable intermediate for the synthesis of biologically active compounds. It undergoes iodination in the presence of iodine and ammonium hydroxide to yield 3,4-di-iodo- and 3,4,5-tri-iodo-pyrazole.

Synthesis

288-13-1

3469-69-0

The general procedure for the synthesis of 4-iodopyrazole from pyrazole is as follows: Example 1: Preparation of 2-amino-3-methyl-5-(1-methyl-1H-pyrazol-4-yl)-5-(3-pyrimidin-5-ylphenyl)-3,5-dihydro-4H-imidazol-4-one Step a): Preparation of compound 2 A mixture of pyrazole (3.00 g, 44.0 mmol), iodine (6.71 g, 26.4 mmol) and ceric ammonium nitrate (14.5 g, 26.4 mmol) in acetonitrile (400 mL) was stirred at room temperature for 2.5 hours. Upon completion of the reaction, the mixture was concentrated and partitioned between ethyl acetate (250 mL) and 5% aqueous sodium bisulfite (250 mL). After addition of water (150 mL), the organic layer was separated, washed with brine (250 mL), dried over anhydrous magnesium sulfate, filtered and concentrated to afford compound 2 (7.80 g, 91% yield) as a white solid with a melting point of 105-108 °C. 1H NMR (300 MHz, CDCl3) δ 7.63 (s, 2H).

References

[1] Tetrahedron Letters, 2001, vol. 42, # 5, p. 863 - 865
[2] Heterocycles, 2003, vol. 60, # 4, p. 879 - 886
[3] Journal of Organic Chemistry, 2003, vol. 68, # 21, p. 8075 - 8079
[4] Tetrahedron Letters, 2001, vol. 42, # 11, p. 2089 - 2092
[5] Russian Chemical Bulletin, 2014, vol. 63, # 2, p. 360 - 367

4-Iodopyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Iodopyrazole Suppliers

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View Lastest Price from 4-Iodopyrazole manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Iodopyrazole 3469-69-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-28
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Iodopyrazole 3469-69-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Henan Aochuang Chemical Co.,Ltd.
Product
4-Iodopyrazole 3469-69-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

3469-69-0, 4-IodopyrazoleRelated Search:

Pyrazole Pyraclostrobin Zolpidem tartrate 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one Zolpidem 4-IODO-1,3,5-TRIMETHYL-1H-PYRAZOLE 3,5-DIMETHYL-4-IODO-1H-PYRAZOLE,3,5-DIMETHYL-4-IODOPYRAZOLE 1-(BENZYLOXY)-4-IODOPYRAZOLE 1-ACETYL-4-IODO-1H-PYRAZOLE,acetyl-4-iodo-1H-pyrazole 3,4-Diiodopyrazole 1-Phenyl-4-iodopyrazole 2-Phenyl-1,5-dimethyl-4-iodo-1H-pyrazole-3(2H)-one 3-Methyl-4-iodopyrazole benzyl-4-iodo-1H-pyrazole,1-BENZYL-4-IODO-1H-PYRAZOLE,1H-(N-BENZYL)-4-IODOPYRAZOLE 5-IODO-1H-PYRAZOLE TERT-BUTYL 4-IODOPYRAZOLE-1-CARBOXYLATE,1-BOC-4-IODOPYRAZOLE,T-BUTYL 4-IODO-1H-PYRAZOLE-1-CARBOXYLATE 1-METHYL-4-IODO-1H-PYRAZOLE (4-IODO-3-NITRO-1H-PYRAZOL-1-YL)ACETIC ACID

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