(R)-1-N-BOC-2-CYANO-PIPERIDINE

Product Name: (R)-1-N-BOC-2-CYANO-PIPERIDINE
CAS No.: 940000-26-0
Chemical Name: (R)-1-N-BOC-2-CYANO-PIPERIDINE
Synonyms: (R)-N-Boc-2-cyanopiperidine;(R)-1-Boc-2-cyanopiperidine;(R)-1-N-BOC-2-CYANO-PIPERIDINE;1-N-BOC-2-(R)-CYANO-PIPERIDINE;tert-butyl (R)-2-cyanopiperidine-1-carboxylate;(R)-TERT-BUTYL 2-CYANOPIPERIDINE-1-CARBOXYLATE;tert-butyl (2R)-2-cyanopiperidine-1-carboxylate;(2R)-2-Cyano-1-piperidinecarboxylic acid tert-butyl ester;(R)-2-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-piperidinecarboxylic acid, 2-cyano-, 1,1-dimethylethyl ester, (2r)-
CBNumber: CB0456609
Molecular Formula: C11H18N2O2
Formula Weight: 210.27
MOL File: 940000-26-0.mol

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(R)-1-N-BOC-2-CYANO-PIPERIDINE Property

Density: 1.07
storage temp.: 2-8°C
Appearance: White to off-white Solid
optical activity: Consistent with structure
CAS DataBase Reference: 940000-26-0

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: 3439

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0052943
Product name: (R)-1-Boc-2-Cyanopiperidine
Purity: >97.0%
Packaging: 1g
Price: $73
Updated: 2021/12/16

Activate Scientific

Product number: AS3822
Product name: (R)-1-Boc-2-cyanopiperidine
Purity: 97+% ee
Packaging: 1g
Price: $155
Updated: 2021/12/16

ChemScene

Product number: CS-0052943
Product name: (R)-1-Boc-2-Cyanopiperidine
Purity: >97.0%
Packaging: 5g
Price: $220
Updated: 2021/12/16

Activate Scientific

Product number: AS3822
Product name: (R)-1-Boc-2-cyanopiperidine
Purity: 97+% ee
Packaging: 5G
Price: $520
Updated: 2021/12/16

ChemScene

Product number: CS-0052943
Product name: (R)-1-Boc-2-Cyanopiperidine
Purity: >97.0%
Packaging: 25g
Price: $554
Updated: 2021/12/16

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(R)-1-N-BOC-2-CYANO-PIPERIDINE Chemical Properties,Usage,Production

Synthesis

848488-91-5

940000-26-0

General procedure for the synthesis of (R)-1-BOC-2-cyanopiperidine from R-N-Boc-prolinamide: b) Synthesis of 1,1-dimethylethyl (2R)-2-(aminocarbonyl)-1-pyrrolidine carboxylate. To a solution of 1,1-dimethylethyl (2R)-2-(aminocarbonyl)-1-piperidine carboxylate (269 mg, 1.17 mmol) in tetrahydrofuran (THF, 10 mL) was added sequentially triethylamine (0.33 mL, 2.34 mmol) and trifluoroacetic anhydride (0.17 mL, 1.17 mmol) at 0 °C. The reaction mixture was stirred at 0 °C for 1 h and then concentrated under vacuum. The concentrated residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated sodium bicarbonate solution, 0.5 N hydrochloric acid and brine. The organic phase was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to afford 1,1-dimethylethyl (2R)-2-cyano-1-piperidine carboxylate (255 mg, 99% yield) as a crystalline solid. The 1H NMR (CDCl3) data of the product were as follows: δ 5.23 (br, 1H), 4.05 (br, 1H), 2.93 (br, 1H), 1.93-1.39 (m, 6H), 1.46 (s, 9H).

References

[1] Patent: WO2006/116764, 2006, A1. Location in patent: Page/Page column 121; 151

(R)-1-N-BOC-2-CYANO-PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-N-BOC-2-CYANO-PIPERIDINE Suppliers

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940000-26-0, (R)-1-N-BOC-2-CYANO-PIPERIDINERelated Search:

(R)-1-BOC-2-BENZYLPIPERAZINE tert-butyl (R)-3-(2-bromophenyl)piperidine-1-carboxylate (R)-1-N-Boc-2-methylpiperazine tert-butyl (R)-3-(4-bromophenyl)piperidine-1-carboxylate (R)-tert-butyl 3-(2-aMinoethyl)pyrrolidine-1-carboxylate (R)-1-Boc-2-propylpiperazine tert-butyl (R)-3-(3-bromophenyl)-1,4-diazepane-1-carboxylate tert-butyl (R)-3-(4-formylphenyl)piperidine-1-carboxylate N-1-Boc-2-Phenylpiperazine (R)-2-THIOCARBAMOYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl (R)-3-(4-bromophenyl)-1,4-diazepane-1-carboxylate tert-butyl (R)-3-(3-bromophenyl)piperazine-1-carboxylate tert-butyl (R)-3-(4-bromophenyl)piperazine-1-carboxylate (R)-1-Boc-2-ethylPiperazine 1-Piperidinecarboxylicacid,2-ethyl-,1,1-dimethylethylester,(2R)-(9CI) tert-Butyl (R)-2-benzylpiperidine-1-carboxylate (R)-tert-butyl 3-((methylamino)methyl)piperidine-1-carboxylate tert-butyl (R)-3-(3-ethynylphenyl)piperazine-1-carboxylate

(R)-2-CYANO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(R)-1-N-BOC-2-CYANO-PIPERIDINE

(R)-TERT-BUTYL 2-CYANOPIPERIDINE-1-CARBOXYLATE

1-N-BOC-2-(R)-CYANO-PIPERIDINE

(R)-1-Boc-2-cyanopiperidine

(R)-N-Boc-2-cyanopiperidine

tert-butyl (2R)-2-cyanopiperidine-1-carboxylate

(2R)-2-Cyano-1-piperidinecarboxylic acid tert-butyl ester

1-piperidinecarboxylic acid, 2-cyano-, 1,1-dimethylethyl ester, (2r)-

tert-butyl (R)-2-cyanopiperidine-1-carboxylate

940000-26-0