Description
ChemicalBook > CAS DataBase List > BAPTA-AM

BAPTA-AM

Description
Product Name
BAPTA-AM
CAS No.
126150-97-8
Chemical Name
BAPTA-AM
Synonyms
CS-968;BAPTA-AM;DAPTA-AM;BAPTA AM, >=98%;BAPTA/AM(BAPTA-AM);BAPTA-AM, Ca2+ chelator;BAPTA-AM, 10 mM in DMSO;BAPTA, AM *CAS 126150-97-8*;BAPTA/AM;BAPTAAM;BAPTA AM;BAPTA-AM;BAPTA, AM *UltraPure Grade* *CAS 126150-97-8*
CBNumber
CB0461324
Molecular Formula
C34H40N2O18
Formula Weight
764.68
MOL File
126150-97-8.mol
More
Less

BAPTA-AM Property

Melting point:
86-90°C
Boiling point:
796.1±60.0 °C(Predicted)
Density 
1.350±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in chloroform, dimethyl sulfoxide
form 
powder
pka
1.69±0.50(Predicted)
color 
White
Appearance
white to beige solid
λmax
287 nm
BRN 
7458534
Stability:
Light Sensitive
Biological Applications
Calcium indicators; treating cancer,chronic bacterial infection,glaucoma,ocular hypertension,HIV-associated conditions,infectious diseases,neurodegenerative disorders,neurological conditions,psychiatric conditions
InChIKey
YJIYWYAMZFVECX-UHFFFAOYSA-N
SMILES
C(OC1=CC=CC=C1N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O)COC1=CC=CC=C1N(CC(OCOC(C)=O)=O)CC(OCOC(C)=O)=O
CAS DataBase Reference
126150-97-8(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
8-10-21
HS Code 
2921490090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A1076
Product name
BAPTA-AM
Purity
≥95% (HPLC)
Packaging
25mg
Price
$289
Updated
2025/07/31
Sigma-Aldrich
Product number
196419
Product name
BAPTA/AM - CAS 126150-97-8 - Calbiochem
Purity
Membrane-permeable form of BAPTA.
Packaging
25MG
Price
$274
Updated
2025/07/31
Sigma-Aldrich
Product number
196419
Product name
BAPTA/AM - CAS 126150-97-8 - Calbiochem
Purity
Membrane-permeable form of BAPTA.
Packaging
100mg
Price
$619
Updated
2022/05/15
TCI Chemical
Product number
T2845
Product name
Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate
Packaging
20MG
Price
$117
Updated
2025/07/31
TCI Chemical
Product number
T2845
Product name
Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate
Packaging
200MG
Price
$693
Updated
2025/07/31
More
Less

BAPTA-AM Chemical Properties,Usage,Production

Description

BAPTA-AM is a selective, membrane-permeable calcium chelator.

Description

BAPTA-AM (126150-97-8) is a selective cell permeable Ca2+ chelator. It is a widely used intracellular calcium sponge.1,2 Rapidly taken up by cells where it is irreversibly hydrolyzed to BAPTA by intracellular esterases. Pretreatment of cells with BAPTA-AM inhibits thapsigargin-induced responses.3

Chemical Properties

Off-White to Light Yellow Solid

Uses

A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores.

Uses

BAPTA is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons. BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases. It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling. It can also be used in animals. BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).

Uses

A cell permeable derivative of BAPTA which is widely used as an intracellular calcium sponge. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9

Uses

BAPTA-AM is a lipophilic diester of BAPTA used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9

Definition

ChEBI: 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetic acid acetyloxymethyl ester is an alpha-amino acid ester.

General Description

BAPTA-AM inhibits free radical-mediated toxicity, enhances apoptosis in non-neuronal cells and protects neurons from ischemic damage. It regulates ion channels and blocks neuronal Ca2+-activated K+?channel currents. BAPTA-AM maintains intracellular Ca2+ homeostasis.

reaction suitability

reagent type: chelator

Biological Activity

Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat No. 2786 ). Blocks hK v 1.5, hERG and hK v 1.3 channels (K i values are 1.23, 1.30 and 1.45 μ M respectively). Displays antithrombotic activity in vitro .

Biochem/physiol Actions

Selective chelator of intracellular Ca2+ stores.

storage

-20°C

References

[1] J B SMITH. Cytosolic calcium as a second messenger for collagen-induced platelet responses.[J]. Biochemical Journal, 1992, 288 ( Pt 3): 925-929. DOI:10.1042/bj2880925
[2] YOSHIDA A. Role of Calcium Ion in Induction of Apoptosis by Etoposide in Human Leukemia HL-60 Cells[J]. Biochemical and biophysical research communications, 1993, 196 2: Pages 927-934. DOI:10.1006/bbrc.1993.2338
[3] S. JIANG. Intracellular Ca2+ Signals Activate Apoptosis in Thymocytes: Studies Using the Ca2+-ATPase Inhibitor Thapsigargin[J]. Experimental cell research, 1994, 212 1: Pages 84-92. DOI:10.1006/excr.1994.1121

Abs/Em Maxima

274 (complex)/372 nm

BAPTA-AM Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BAPTA-AM Suppliers

Canada 1 China 175 Europe 2 Germany 2 India 3 Japan 4 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 7 United States 31 Global 229
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Selleck Chemicals LLC
Tel
--
Fax
--
Email
info@selleckchem.com
Country
United States
ProdList
824
Advantage
60
AAT Bioquest, Inc.
Tel
--
Fax
--
Email
jack@aatbio.com
Country
United States
ProdList
169
Advantage
50
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
TimTec Corporation
Tel
--
Fax
--
Country
United States
ProdList
1945
Advantage
58
www.vwrsp.com
Tel
--
Fax
--
Email
B2B@VWR.com
Country
United States
ProdList
622
Advantage
86
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Invitrogen Corporation
Tel
--
Fax
--
Email
supplycenters@invitrogen.com
Country
United States
ProdList
86
Advantage
86
AnaSpec, Inc.
Tel
--
Fax
--
Email
service@anaspec.com
Country
United States
ProdList
4871
Advantage
77
A.G. Scientific, Inc.
Tel
--
Fax
--
Email
support@agscientific.com
Country
United States
ProdList
1066
Advantage
71
BIOMOL INTERNATIONAL, LP
Tel
--
Fax
--
Email
info@biomol.com
Country
United States
ProdList
1499
Advantage
77
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Zymed Laboratories Inc.
Tel
--
Fax
--
Country
United States
ProdList
3068
Advantage
86
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
More
Less

View Lastest Price from BAPTA-AM manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
BAPTA-AM 126150-97-8
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%min
Supply Ability
100kg
Release date
2025-08-29
Watson Biotechnology Co.,Ltd
Product
BAPTA-AM 126150-97-8
Price
US $0.00-0.00/G
Min. Order
1G
Purity
99%
Supply Ability
100G
Release date
2024-12-20
Zhuozhou Wenxi import and Export Co., Ltd
Product
BAPTA-AM 126150-97-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

126150-97-8, BAPTA-AMRelated Search:

Fluo 3-AM BAPTA Fura 2-AM BAPTA-AM RHOD-2, AM 5,5'-DIFLUORO BAPTA, AM NITR 5/AM 5,5'-DIBROMO BAPTA AM INDO 1-AM BAPTA-AM 5 5'-DIFLUOR-BAPTA-AM 1,2.BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID, TETRAACETOXYMETHYL ESTER; BAPTA-AM 4,4'-Difluoro-BAPTA-AM 5,5I DIFLUORO BAPTA(AM) BAPTA, AM *UltraPure Grade* 5,5'-Dimethl-BAPTA-AM 5,5'-DIMETHYL BAPTA, AM 5,5'-DINITRO BAPTA, AM

  • 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER
  • BAPTA-AM
  • BAPTA/AM;BAPTAAM;BAPTA AM;BAPTA-AM
  • CS-968
  • BAPTA/AM(BAPTA-AM)
  • acetyloxymethyl 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetate
  • 1,2-bis(2-aminophenoxy)ethane-n,n,n0, n0-tetraacetic Acid Tetrakis(acetoxymethyl Ester)
  • Glycine, n,n0-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[n-[2- [(acetyloxy)methoxy]-2-oxoethyl]-, Bis[(acetyloxy)methyl] ester
  • BAPTA, AM *CAS 126150-97-8*
  • BAPTA, AM *UltraPure Grade* *CAS 126150-97-8*
  • DAPTA-AM
  • 1,2-BIS (2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID, TETRAACETOXYMETHYL ESTER
  • 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID TETRAKIS(ACETOXY-METHYL) ESTER
  • 1,2-BIS(O-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID TETRA(ACETOXYMETHYL) ESTER
  • O,O'-Bis(2-aminophenyl)ethyleneglycol-N,N,N',N'-tetraaceticacid,tetraacetoxymethylester
  • 1,2-Bis(2-aminophenoxy)ethane-N,N,N'',N''-tetraacetic acid<br>tetrakis(acetoxymethyl ester)
  • N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)Methoxy]-2-oxoethyl]glycine 1,1'-Bis[(acetyloxy)Methyl] Ester
  • 1,2-Bis(2-aMinophenoxy)ethane-N,N,N`,N`-tetraacetic acid tetrakis(acetoxyMethyl ester), (BAPTA AM)
  • Tetrakis(acetoxyMethyl) 1,2-Bis(2-aMinophenoxy)ethane-N,N,N',N'-tetraacetate
  • Tetrakis(acetoxyMethyl) 2,2',2'',2'''-(((ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(azanetriyl))tetraacetate
  • 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER(BAPTA-AM)
  • BAPTA-AM 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)
  • BAPTA AM, >=98%
  • BAPTA, AM ester [1,2- Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester]
  • O,O'-Bis(2-aminophenyl)ethyleneglycol-N,N,N',N'-tetraacetic Acid, Tetraacetoxymethyl Ester 50mM/l
  • Glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-, 1,1'-bis[(acetyloxy)methyl] ester
  • BAPTA-AM, Ca2+ chelator
  • BAPTA-AM, 10 mM in DMSO
  • BAPTA/AM - CAS 126150-97-8 - Calbiochem[196419]
  • 126150-97-8
  • C34H40N2O18
  • Intracellular Calcium Signaling
  • BioChemical
  • Cell Signaling and Neuroscience
  • Calcium Signaling Research Tools
  • Calcium Chelators
  • Cell Biology
  • Aromatic
  • Inhibitors
  • Chelating Agents & Ligands
  • Fluorescent Labels & Indicators
  • Amines
  • Aromatics