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SM16

Product Name
SM16
CAS No.
614749-78-9
Chemical Name
SM16
Synonyms
SM16;CS-2835;SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16;4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;4-[5-(2H-1,3-benzodioxol-5-yl)-4-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-
CBNumber
CB04656566
Molecular Formula
C25H26N4O3
Formula Weight
430.5
MOL File
614749-78-9.mol
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SM16 Property

Boiling point:
691.3±55.0 °C(Predicted)
Density 
1.354±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:65.0(Max Conc. mg/mL);150.99(Max Conc. mM)
form 
A solid
pka
11.23±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
6245
Product name
SM16
Purity
≥98%(HPLC)
Packaging
10
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0042167
Product name
SM16
Purity
99.96%
Packaging
5mg
Price
$110
Updated
2021/12/16
ChemScene
Product number
CS-0042167
Product name
SM16
Purity
99.96%
Packaging
10mg
Price
$190
Updated
2021/12/16
ChemScene
Product number
CS-0042167
Product name
SM16
Purity
99.96%
Packaging
50mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0042167
Product name
SM16
Purity
99.96%
Packaging
100mg
Price
$950
Updated
2021/12/16
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SM16 Chemical Properties,Usage,Production

Biological Activity

SM 16 is an ALK5/ALK4 kinase inhibitor with Ki values of 10 and 1.5 nM, respectively.

in vivo

SM 16 penetrates tumor cells in vivo , suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single ip bolus of 20 mg/kg SM 16. The growth of established AB12 tumors is significantly inhibited by 5 mg/kg/d SM 16 (P<0.001) delivered via sc miniosmotic pumps over 28 days.

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target

Ki: ALK5 (10 nM), ALK4 (1.5 nM)

storage

Store at -20°C

SM16 Preparation Products And Raw materials

Raw materials

Preparation Products

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SM16 Suppliers

ShangHai Caerulum Pharma Discovery Co., Ltd.
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18149758185 18149758185
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sales-cpd@caerulumpharma.com
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China
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
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+86-21-52996696
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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Shanghai Chaolan Chemical Technology Center
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021-QQ:65489617 15618227136
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Career Henan Chemica Co
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DC Chemicals
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Hubei Kele Fine Chemical Co., Ltd
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InvivoChem
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Chemia Biotechnology(Shanghai) Co., Ltd
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614749-78-9, SM16Related Search:


  • 4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide
  • CS-2835
  • Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-
  • SM16
  • SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16
  • 4-[5-(2H-1,3-benzodioxol-5-yl)-4-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide
  • 614749-78-9