ChemicalBook > CAS DataBase List > SM16

SM16

Product Name: SM16
CAS No.: 614749-78-9
Chemical Name: SM16
Synonyms: SM16;CS-2835;SM 16, 10 mM in DMSO;SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16;4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;4-[5-(2H-1,3-benzodioxol-5-yl)-4-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-
CBNumber: CB04656566
Molecular Formula: C25H26N4O3
Formula Weight: 430.5
MOL File: 614749-78-9.mol

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SM16 Property

Boiling point:: 691.3±55.0 °C(Predicted)
Density: 1.354±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:65.0(Max Conc. mg/mL);150.99(Max Conc. mM)
form: A solid
pka: 11.23±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6245
Product name: SM16
Purity: ≥98%(HPLC)
Packaging: 10
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0042167
Product name: SM16
Purity: 99.96%
Packaging: 50mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0042167
Product name: SM16
Purity: 99.96%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0042167
Product name: SM16
Purity: 99.96%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

ChemScene

Product number: CS-0042167
Product name: SM16
Purity: 99.96%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

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SM16 Chemical Properties,Usage,Production

Uses

SM 16 is a ALK5/ALK4 kinase inhibitor with Kis of 10 and 1.5 nM, respectively.

Biological Activity

SM 16 is an ALK5/ALK4 kinase inhibitor with Ki values of 10 and 1.5 nM, respectively.

in vivo

SM 16 penetrates tumor cells in vivo , suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single ip bolus of 20 mg/kg SM 16. The growth of established AB12 tumors is significantly inhibited by 5 mg/kg/d SM 16 (P<0.001) delivered via sc miniosmotic pumps over 28 days.

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target

Ki: ALK5 (10 nM), ALK4 (1.5 nM)

storage

Store at -20°C

References

[1] Suzuki E, et al. A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res. 2007 Mar 1;67(5):2351-9. DOI:10.1158/0008-5472.CAN-06-2389
[2] Fu K, et al. SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):665-71. DOI:10.1161/ATVBAHA.107.158030
[3] Engebretsen KV, et al. Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5. J Mol Cell Cardiol. 2014 Nov;76:148-57. DOI:10.1016/j.yjmcc.2014.08.008

SM16 Preparation Products And Raw materials

Raw materials

Preparation Products

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SM16 Suppliers

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614749-78-9, SM16Related Search:

4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide

CS-2835

Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-

SM16

SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16

4-[5-(2H-1,3-benzodioxol-5-yl)-4-(6-methylpyridin-2-yl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide

SM 16, 10 mM in DMSO

614749-78-9