ChemicalBook > CAS DataBase List > SM16
SM16
- Product Name
- SM16
- CAS No.
- 614749-78-9
- Chemical Name
- SM16
- Synonyms
- SM16;CS-2835;SM-16,TGF-β Receptor,Inhibitor,inhibit,SM 16,Transforming growth factor beta receptors,SM16;4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide;Bicyclo[2.2.2]octane-1-carboxamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]-
- CBNumber
- CB04656566
- Molecular Formula
- C25H26N4O3
- Formula Weight
- 430.5
- MOL File
- 614749-78-9.mol
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SM16 Property
- Boiling point:
- 691.3±55.0 °C(Predicted)
- Density
- 1.354±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:65.0(Max Conc. mg/mL);150.99(Max Conc. mM)
- form
- A solid
- pka
- 11.23±0.10(Predicted)
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N-Bromosuccinimide Price
Tocris
- Product number
- 6245
- Product name
- SM16
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $300
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0042167
- Product name
- SM16
- Purity
- 99.96%
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0042167
- Product name
- SM16
- Purity
- 99.96%
- Packaging
- 10mg
- Price
- $190
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0042167
- Product name
- SM16
- Purity
- 99.96%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0042167
- Product name
- SM16
- Purity
- 99.96%
- Packaging
- 100mg
- Price
- $950
- Updated
- 2021/12/16
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SM16 Chemical Properties,Usage,Production
Biological Activity
SM 16 is an ALK5/ALK4 kinase inhibitor with Ki values of 10 and 1.5 nM, respectively.
in vivo
SM 16 penetrates tumor cells in vivo , suppressing tumor phosphorylated Smad2/3 levels for at least 3 h following treatment of tumor-bearing mice with a single ip bolus of 20 mg/kg SM 16. The growth of established AB12 tumors is significantly inhibited by 5 mg/kg/d SM 16 (P<0.001) delivered via sc miniosmotic pumps over 28 days.
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target
Ki: ALK5 (10 nM), ALK4 (1.5 nM)
storage
Store at -20°C
SM16 Preparation Products And Raw materials
Raw materials
Preparation Products
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