N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide

ChemicalBook > CAS DataBase List > N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide

N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide

Product Name: N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide
CAS No.: 1011244-68-0
Chemical Name: N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide
Synonyms: TFAP;CS-2896;COX-1 Inhibitor IV;COX-1 Inhibitor IV(TFAP);N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide;N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide;Benzamide, N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)-;Cyclooxygenase,COX,inhibit,Endogenous Metabolite,TFAP,Inhibitor
CBNumber: CB04663492
Molecular Formula: C13H10F3N3O
Formula Weight: 281.23
MOL File: 1011244-68-0.mol

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N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide Property

Boiling point:: 360.8±42.0 °C(Predicted)
Density: 1.425±0.06 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: DMF: 5mg/mL; DMSO: 10mg/mL; Ethanol: 10mg/mL; Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL
form: Off-white solid
pka: 11.02±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26745
Product name: TFAP
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 26745
Product name: TFAP
Packaging: 25mg
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 26745
Product name: TFAP
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 26745
Product name: TFAP
Packaging: 10mg
Price: $199
Updated: 2024/03/01

ChemScene

Product number: CS-0063093
Product name: TFAP
Purity: 99.97%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

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N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide Chemical Properties,Usage,Production

Biological Activity

TFAP (N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide) is a cell-permeable and selective cyclooxygenase-1 (COX-1) inhibitor with IC50 of 0.8 μM.

in vitro

TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC ₅₀ of 0.8 μM, while that against COX-2 is over 200 μM.

target

Target	Value
COX-1 (Cell-free assay)	0.8 μM

N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1011244-68-0, N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamideRelated Search:

N-(5-Amino-2-pyridinyl)-4-trifluoromethylbenzamide

TFAP

CS-2896

COX-1 Inhibitor IV(TFAP)

COX-1 Inhibitor IV

N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide

Benzamide, N-(5-amino-2-pyridinyl)-4-(trifluoromethyl)-

Cyclooxygenase,COX,inhibit,Endogenous Metabolite,TFAP,Inhibitor

1011244-68-0