A-395
- Product Name
- A-395
- CAS No.
- 2089148-72-9
- Chemical Name
- A-395
- Synonyms
- A-395;A-395, 10 mM in DMSO;A-395,Histone Methyltransferase,A395,A 395,Inhibitor,inhibit;(3R,4S)-1-(7-Fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine;3-Pyrrolidinamine, 1-(7-fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-[4-[4-(methylsulfonyl)-1-piperazinyl]phenyl]-, (3R,4S)-
- CBNumber
- CB04667470
- Molecular Formula
- C26H35FN4O2S
- Formula Weight
- 486.65
- MOL File
- 2089148-72-9.mol
A-395 Property
- Boiling point:
- 612.2±65.0 °C(Predicted)
- Density
- 1.30±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 100 mg/mL (205.49 mM)
- form
- Solid
- pka
- 8.49±0.40(Predicted)
- color
- White to yellow
- Water Solubility
- H2O: 10mg/mL, clear
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0021615
- Product name
- A-395
- Purity
- 99.31%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-0021615
- Product name
- A-395
- Purity
- 99.31%
- Packaging
- 10mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- CS-0021615
- Product name
- A-395
- Purity
- 99.31%
- Packaging
- 25mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- DC10129
- Product name
- A395
- Purity
- >98%
- Packaging
- 100mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- DC10129
- Product name
- A395
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1750
- Updated
- 2021/12/16
A-395 Chemical Properties,Usage,Production
Biological Activity
A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development), an essential component of Polycomb repressive complex 2 (PRC2), involved in transcriptional repression through methylation of histone H3K27. A-395 has been found to bind to EED in vitro with a Ki value of 0.4 nM, inhibit the PRC2 complex with an IC50 value 34 nM for methylation of H3K27, and have >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In RD rhabdoid tumor cell line A-395 inhibited the PRC2 complex with an IC50 value of 90 nM, inhibiting the formation of H3K27me3. For characterization details of A-395, please visit the A-395 probe summary on the Structural Genomics Consortium (SGC) website.
A-395N is the negative control for the active enantiomer, A-395. A-395N is available from Sigma. To learn more about and purchase A-395N, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
A-395 Preparation Products And Raw materials
Raw materials
Preparation Products
A-395 Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
- 58