AZD3229

Product Name: AZD3229
CAS No.: 2248003-60-1
Chemical Name: AZD3229
Synonyms: NB-003;AZD3229;AZD3229 (AZD-3229;AZD3229, 10 mM in DMSO;AZD3229;AZD 3229;AZD-3229;Inhibitor,AZD3229,CD117,AZD 3229,AZD-3229,SCFR,c-Kit,inhibit;1H-1,2,3-Triazole-1-acetamide, N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-
CBNumber: CB04667591
Molecular Formula: C24H26FN7O3
Formula Weight: 479.51
MOL File: 2248003-60-1.mol

More

Less

AZD3229 Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:68.67(Max Conc. mg/mL);143.21(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);20.85(Max Conc. mM)
Ethanol:0.3(Max Conc. mg/mL);0.63(Max Conc. mM)
form: A crystalline solid
pka: 12.75±0.70(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 27908
Product name: AZD 3229
Packaging: 500μg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 27908
Product name: AZD 3229
Packaging: 5mg
Price: $286
Updated: 2024/03/01

Cayman Chemical

Product number: 27908
Product name: AZD 3229
Packaging: 1mg
Price: $130
Updated: 2024/03/01

ChemScene

Product number: CS-0065717
Product name: AZD3229
Purity: 99.55%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573321
Product name: AZD3229
Purity: >98%
Packaging: 250mg
Price: $1949.9
Updated: 2021/12/16

More

Less

AZD3229 Chemical Properties,Usage,Production

Uses

AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 inhibits c-KIT with an IC50 value of 223.3 nM[1][2].

Biological Activity

AZD3229 is a potent pan-Kit (c-Kit) mutant inhibitor with GI50 of 1-50 nM in a Kit (c-Kit) mutant-driven Ba/F3 cell line. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V).

in vivo

AZD3229 has high bioavailability, low clearance and small volume of distribution in preclinical animal models of mice, rats and dogs. In an in vivo model constructed using the Ba/F3 cell line, AZD3229 at 20 mg/kg bid induces regression of tumor volume more effectively than regorafenib and imatinib at 100 mg/kg qd.

target

Target	Value
Kit ()
PDGFRα ()
PDGFRβ ()

References

[1] Ryu H, et.al. Antitumor Activity of a Novel Tyrosine Kinase Inhibitor AIU2001 Due to Abrogation of the DNA Damage Repair in Non-Small Cell Lung Cancer Cells. Int J Mol Sci. 2019 Sep 24;20(19):4728. DOI:10.3390/ijms20194728
[2] Kettle JG, et al. Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy) quinazolin-4-yl]amino} phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors. J Med Chem. 2018 Oct 11;61(19):8797-8810. DOI:10.1021/acs.jmedchem.8b00938

AZD3229 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AZD3229 Suppliers

China 31 United States 6 Global 37

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2495
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29662
Advantage: 68

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Wuxi Donghe Pharmaceutical Technology Co., Ltd.

Tel: 63313187 15358055255
Fax: QQ：63313187
Email: 63313187@qq.com
Country: China
ProdList: 1985
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

2248003-60-1, AZD3229Related Search:

AZD3229

AZD3229 (AZD-3229

AZD3229;AZD 3229;AZD-3229

Inhibitor,AZD3229,CD117,AZD 3229,AZD-3229,SCFR,c-Kit,inhibit

1H-1,2,3-Triazole-1-acetamide, N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-

AZD3229, 10 mM in DMSO

NB-003

2248003-60-1