CD38 inhibitor 78c

Product Name: CD38 inhibitor 78c
CAS No.: 1700637-55-3
Chemical Name: CD38 inhibitor 78c
Synonyms: 78c;cd38-1;MDK7553;MDK 7553;MDK-7553;CD38i_78c;CD38IN-78c;CD38 IN-78c;CD38-IN-78c;Compound-78c
CBNumber: CB04667733
Molecular Formula: C22H27N3O3S
Formula Weight: 413.53
MOL File: 1700637-55-3.mol

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CD38 inhibitor 78c Property

Boiling point:: 589.8±50.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (60.46 mM; ultrasonic and warming and heat to 60°C)
form: A solid
pka: 3.17±0.20(Predicted)
color: Light yellow to brown
InChI: InChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-
InChIKey: VJQALSOBHVEJQM-QAQDUYKDSA-N
SMILES: N1(C)C2=C(C=C(C3SC=NC=3)C=C2)C(N[C@@H]2CC[C@@H](OCCOC)CC2)=CC1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M349560
Product name: 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone
Packaging: 1mg
Price: $370
Updated: 2021/12/16

DC Chemicals

Product number: DC20332
Product name: CD38inhibitor78c
Purity: >98%
Packaging: 100mg
Price: $800
Updated: 2021/12/16

DC Chemicals

Product number: DC20332
Product name: CD38inhibitor78c
Purity: >98%
Packaging: 250mg
Price: $1400
Updated: 2021/12/16

DC Chemicals

Product number: DC20332
Product name: CD38inhibitor78c
Purity: >98%
Packaging: 1g
Price: $2800
Updated: 2021/12/16

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CD38 inhibitor 78c Chemical Properties,Usage,Production

Description

Thiazoloquin(az)olin(on)es, such as the small molecule 78c, have been identified as potent CD38 inhibitors (CD38i). CD38 inhibitor 78c is a potent, reversible, and uncompetitive inhibitor of CD38. 78c reverses age-related NAD+ decline and ameliorates several metabolic, structural, and molecular ageing features in chronologically aged and progeroid mice. The CD38 inhibitor 78c increases naturally aged mice's lifespan and health span. In addition to a 10% increase in median survival, 78c improved exercise performance, endurance, and metabolic function in mice. The effects of 78c were different between the sexes[1-2].

Uses

4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone is a useful compound and has been evaluated for use as CD38 inhibitors.

storage

Store at -20°C

References

[1] Thais R. Peclat. “CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging.” Aging Cell 21 4 (2022).
[2] Mariana G Tarragó. “A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.” Cell metabolism 27 5 (2018): 1081-1095.e10.

CD38 inhibitor 78c Preparation Products And Raw materials

Raw materials

Preparation Products

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CD38 inhibitor 78c Suppliers

China 55 United States 6 Global 61

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View Lastest Price from CD38 inhibitor 78c manufacturers

Hubei Chuchang Biotech Co., Ltd.

Product: CD38 1700637-55-3
Price: US $0.00-0.00/mg
Min. Order: 1mg
Purity: 98
Supply Ability: 100G
Release date: 2024-04-17

1700637-55-3, CD38 inhibitor 78cRelated Search:

CD38 inhibitor 78c

CD38 inhibitor 1

2(1H)-Quinolinone, 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-

CD38 inhibitor 1 (compound 78c)

4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone

4-((trans-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one

cd38-1

CD38 inhibitor 1,Inhibitor,inhibit,CD-38 inhibitor 1

4-[[trans-4-(2-Methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)quinolin-2(1H)-one

4- (trans 4- (2-methoxyethoxy) cyclohexyl) amino) -1-methyl-6- (thiazol-5-yl) quinoline-2 (1H) - one

CD38 IN-78c

CD38-IN-78c

CD38IN-78c

Cluster of Differentiation 38 Inhibitor

Compound-78c

MDK 7553

MDK7553

MDK-7553

78c

CD38i_78c

CD38IN-78c: CD38 inhibitor 78c

1700637-55-3