ChemicalBook > CAS DataBase List > IITZ-01

IITZ-01

Product Name: IITZ-01
CAS No.: 1807988-47-1
Chemical Name: IITZ-01
Synonyms: IITZ-01;CS-2857;IITZ-01 ，S8764;IITZ-01, 10 mM in DMSO;Autophagy inhibitor IITZ-01;AUTOPHAGY INHIBITOR;IITZ 01;IITZ01;AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01;Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K;N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine;N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine
CBNumber: CB04668033
Molecular Formula: C26H23FN8O
Formula Weight: 482.51
MOL File: 1807988-47-1.mol

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IITZ-01 Property

Boiling point:: 747.0±70.0 °C(Predicted)
Density: 1.420±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO:100.0(Max Conc. mg/mL);207.24(Max Conc. mM)
pka: 11.55±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0067546
Product name: IITZ-01
Purity: 99.80%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: 8048EL
Product name: 4-N-[4-(1H-Benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine
Packaging: 5mg
Price: $162
Updated: 2021/12/16

ChemScene

Product number: CS-0067546
Product name: IITZ-01
Purity: 99.80%
Packaging: 10mg
Price: $210
Updated: 2021/12/16

ChemScene

Product number: CS-0067546
Product name: IITZ-01
Purity: 99.80%
Packaging: 25mg
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-0067546
Product name: IITZ-01
Purity: 99.80%
Packaging: 50mg
Price: $680
Updated: 2021/12/16

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IITZ-01 Chemical Properties,Usage,Production

Uses

IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ.

Biological Activity

IITZ-01 is a potent lysosomal autophagy inhibitor with antitumor activity, with IC50 value of 2.62 μM for PI3Kγ.

in vivo

IITZ-01 (45 mg/kg, ip every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.

Animal Model:	MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr- Foxn ^nu BALB/c female nude mice.
Dosage:	45 mg/kg.
Administration:	Intraperitoneal every alternate day for 4 weeks.
Result:	Inhibited average breast tumor growth when compared with control from third day of treatment.

target

PI3Kγ

2.62 μM (IC ₅₀ )

Autophagy

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IC 50

PI3Kγ: 2.62 μM (IC₅₀); Autophagy

References

[1] Guntuku L, et al. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Oncogene. 2018 Aug 30. DOI:10.1038/s41388-018-0446-2

IITZ-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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IITZ-01 Suppliers

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1807988-47-1, IITZ-01Related Search:

IITZ-01

AUTOPHAGY INHIBITOR;IITZ 01;IITZ01

Autophagy inhibitor IITZ-01

AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01

CS-2857

1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-

N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine

Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K

N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine

IITZ-01, 10 mM in DMSO

IITZ-01 ，S8764

1807988-47-1

C26H23FN8O

API