ChemicalBook > CAS DataBase List > IITZ-01
IITZ-01
- Product Name
- IITZ-01
- CAS No.
- 1807988-47-1
- Chemical Name
- IITZ-01
- Synonyms
- IITZ-01;CS-2857;Autophagy inhibitor IITZ-01;AUTOPHAGY INHIBITOR;IITZ 01;IITZ01;AUTOPHAGY INHIBITOR IITZ-01;IITZ 01;IITZ01;Phosphoinositide 3-kinase,IITZ 01,IITZ01,Apoptosis,IITZ-01,Autophagy,inhibit,Inhibitor,PI3K;N-[4-(1H-Benzimidazol-2-yl)phenyl]-N'-(4-fluorophenyl)-6-(4-morpholinyl)-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diamine, N2-[4-(1H-benzimidazol-2-yl)phenyl]-N4-(4-fluorophenyl)-6-(4-morpholinyl)-
- CBNumber
- CB04668033
- Molecular Formula
- C26H23FN8O
- Formula Weight
- 482.51
- MOL File
- 1807988-47-1.mol
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IITZ-01 Property
- Boiling point:
- 747.0±70.0 °C(Predicted)
- Density
- 1.420±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- DMSO:100.0(Max Conc. mg/mL);207.24(Max Conc. mM)
- pka
- 11.55±0.10(Predicted)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0067546
- Product name
- IITZ-01
- Purity
- 99.80%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
AK Scientific
- Product number
- 8048EL
- Product name
- 4-N-[4-(1H-Benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine
- Packaging
- 5mg
- Price
- $162
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0067546
- Product name
- IITZ-01
- Purity
- 99.80%
- Packaging
- 10mg
- Price
- $210
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0067546
- Product name
- IITZ-01
- Purity
- 99.80%
- Packaging
- 25mg
- Price
- $420
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0067546
- Product name
- IITZ-01
- Purity
- 99.80%
- Packaging
- 50mg
- Price
- $680
- Updated
- 2021/12/16
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IITZ-01 Chemical Properties,Usage,Production
Biological Activity
IITZ-01 is a potent lysosomal autophagy inhibitor with antitumor activity, with IC50 value of 2.62 μM for PI3Kγ.
in vivo
IITZ-01 (45 mg/kg, ip every alternate day for 4 weeks) inhibits average breast tumor growth when compared with control from third day of treatment in triple-negative breast tumor models in mice.
| Animal Model: | MDA-MB-231 (TNBC)/green fluorescent protein (GFP) orthotropic breast cancer xenografts were developed in CrTac:NCr- Foxn nu BALB/c female nude mice. |
| Dosage: | 45 mg/kg. |
| Administration: | Intraperitoneal every alternate day for 4 weeks. |
| Result: | Inhibited average breast tumor growth when compared with control from third day of treatment. |
target
| PI3Kγ 2.62 μM (IC 50 ) | Autophagy < /span> |
IITZ-01 Preparation Products And Raw materials
Raw materials
Preparation Products
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