KEA1-97

Product Name: KEA1-97
CAS No.: 2138882-71-8
Chemical Name: KEA1-97
Synonyms: KEA1-97;KEA1-97 >=98% (HPLC);KEA1-97, 10 mM in DMSO;4,6-Dichloro-N-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine;1,3,5-Triazin-2-amine, 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)-;Apoptosis,KEA1 97,Proliferation,Apoptotic,Caspase,inhibit,KEA-1-97,DCTalkyne,KEA1-97,231MFP,Inhibitor,Selective,KEA197
CBNumber: CB04668109
Molecular Formula: C15H9Cl2FN4
Formula Weight: 335.16
MOL File: 2138882-71-8.mol

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KEA1-97 Property

Boiling point:: 530.3±52.0 °C(Predicted)
Density: 1.466±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 100 mg/mL (298.36 mM; Need ultrasonic)
pka: 0.57±0.10(Predicted)
form: Solid
color: White to light yellow
InChI: InChI=1S/C15H9Cl2FN4/c16-13-20-14(17)22-15(21-13)19-12-7-3-10(4-8-12)9-1-5-11(18)6-2-9/h1-8H,(H,19,20,21,22)
InChIKey: DUROVTLUQOYUPH-UHFFFAOYSA-N
SMILES: N1=C(Cl)N=C(Cl)N=C1NC1=CC=C(C2=CC=C(F)C=C2)C=C1

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2180
Product name: KEA1-97
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $95.7
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML2180
Product name: KEA1-97
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $261.8
Updated: 2026/03/19

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KEA1-97 Chemical Properties,Usage,Production

Description

KEA1-97 is a Thioredoxin-Caspase 3 interaction disruptor. It was found to target lysine 72 of thioredoxin, inhibiting its interactions with caspase 3 and inducing apoptosis without affecting other thioredoxin activity. KEA1-97 induced apoptosis in breast cancer cells and treatment of immune-deficient SCID mice at 5 mg/kg ip impaired breast tumor xenograft growth.

Uses

KEA1-97 is a selective Thioredoxin-caspase 3 interaction disruptor (IC50=10 μM). KEA1-97 disrupts the interaction of thioredoxin with caspase 3, activates caspases, and induces apoptosis without affecting thioredoxin activity[1].

in vivo

KEA1-97 (5 mg/kg; i.p.; 50 days) attenuates tumor xenograft growth^[1].

Animal Model:	Immune-deficient SCID mice
Dosage:	5 mg/kg
Administration:	I.p.; 50 days
Result:	Attenuated tumor xenograft growth.

IC 50

Caspase 3: 10 μM (IC₅₀); Thioredoxin: 10 μM (IC₅₀)

References

[1] Anderson KE, et al. Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity. ACS Chem Biol. 2017;12(10):2522-2528. DOI:10.1021/acschembio.7b00711

KEA1-97 Preparation Products And Raw materials

Raw materials

Preparation Products

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KEA1-97 Suppliers

China 38 United States 3 Global 41

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16055
Advantage: 64

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9532
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
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Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1140
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Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
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Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9856
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Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44896
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2138882-71-8, KEA1-97Related Search:

KEA1-97

1,3,5-Triazin-2-amine, 4,6-dichloro-N-(4'-fluoro[1,1'-biphenyl]-4-yl)-

KEA1-97 >=98% (HPLC)

4,6-Dichloro-N-(4'-fluoro-[1,1'-biphenyl]-4-yl)-1,3,5-triazin-2-amine

Apoptosis,KEA1 97,Proliferation,Apoptotic,Caspase,inhibit,KEA-1-97,DCTalkyne,KEA1-97,231MFP,Inhibitor,Selective,KEA197

KEA1-97, 10 mM in DMSO

2138882-71-8

C15H9Cl2FN4