ChemicalBook > CAS DataBase List > 2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL

2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL

Product Name
2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL
CAS No.
21168-72-9
Chemical Name
2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL
Synonyms
1-Piperidineethanol, 4-(aminomethyl)-;2-[4-(Aminomethyl)-1-piperidinyl]ethanol;2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL;2-[4-(aminomethyl)piperidin-1-yl]ethan-1-ol;2-[4-(aminomethyl)piperidin-1-yl]ethanol(SALTDATA: FREE)
CBNumber
CB0467816
Molecular Formula
C8H18N2O
Formula Weight
158.24
MOL File
21168-72-9.mol
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2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL Property

storage temp. 
2-8°C(protect from light)
form 
solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CBR01881
Product name
2-[4-(Aminomethyl)piperidin-1-yl]ethanol
Purity
Aldrich<SUP>CPR</SUP>
Packaging
1 g
Price
$179
Updated
2025/07/31
AK Scientific
Product number
8341CQ
Product name
2-(4-(Aminomethyl)piperidin-1-yl)ethanol
Packaging
1g
Price
$196
Updated
2021/12/16
Oakwood
Product number
024711
Product name
2-(4-Aminomethylpiperidin-1-yl)ethanol
Purity
tech
Packaging
1g
Price
$225
Updated
2021/12/16
AK Scientific
Product number
8341CQ
Product name
2-(4-(Aminomethyl)piperidin-1-yl)ethanol
Packaging
10g
Price
$861
Updated
2021/12/16
Ambeed
Product number
A191390
Product name
2-(4-(Aminomethyl)piperidin-1-yl)ethanol
Purity
97%
Packaging
250mg
Price
$42
Updated
2021/12/16
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2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL Chemical Properties,Usage,Production

Synthesis

21168-73-0

21168-72-9

GENERAL STEPS: Bornyl dimethyl sulfide ether (BH3-SMe2, 220 mg, 2.4 mmol) was added slowly and dropwise to an anhydrous solution of 1-(2-hydroxyethyl)piperidine-4-carbonitrile (300 mg, 2 mmol) in anhydrous tetrahydrofuran (THF, 5 mL) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 2 hours. Subsequently, the reaction was quenched by slow addition of water and then neutralized by addition of potassium carbonate (K2CO3). The reaction mixture was filtered and the filtrate was concentrated under reduced pressure to afford the target compound 2-(4-(aminomethyl)piperidin-1-yl)ethanol (150 mg, 47% yield). The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H-NMR, CDCl3, 400 MHz): δ 3.61-3.70 (m, 1H), 3.59 (t, J = 5.6 Hz, 2H), 2.91 (d, J = 11.6 Hz, 2H), 2.57 (d, J = 6.4 Hz, 2H), 2.50 (t, J = 5.6 Hz, 2H), 2.50 (t, J = 5.6 Hz, 2H) 1.97-2.10 (m, 2H), 1.63-1.70 (m, 2H), 1.15-1.35 (m, 2H).

References

[1] Patent: WO2013/13188, 2013, A1. Location in patent: Paragraph 00349; 00350
[2] Patent: US9416132, 2016, B2. Location in patent: Page/Page column 143; 144

2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-AMINOMETHYL-PIPERIDIN-1-YL)-ETHANOL Suppliers

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