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SPIROXATRINE

Product Name
SPIROXATRINE
CAS No.
1054-88-2
Chemical Name
SPIROXATRINE
Synonyms
R 5188;SPIROXATRINE;Spiroxatrine (R 5188);SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5;8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE;1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-;8-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;(+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE;R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one
CBNumber
CB4157162
Molecular Formula
C22H25N3O3
Formula Weight
379.45
MOL File
1054-88-2.mol
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SPIROXATRINE Property

Melting point:
215.8-218.0 °C
Boiling point:
602.8±55.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
0.1 M HCl: moderately soluble
form 
powder
pka
15.03±0.20(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
0631
Product name
Spiroxatrine
Packaging
10
Price
$145
Updated
2021/12/16
Tocris
Product number
0631
Product name
Spiroxatrine
Packaging
50
Price
$593
Updated
2021/12/16
TRC
Product number
S683503
Product name
Spiroxatrine(R5188)
Packaging
10mg
Price
$105
Updated
2021/12/16
Usbiological
Product number
466452
Product name
Spiroxatrine
Packaging
10mg
Price
$382
Updated
2021/12/16
Usbiological
Product number
256729
Product name
Spiroxatrine
Packaging
10mg
Price
$389
Updated
2021/12/16
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SPIROXATRINE Chemical Properties,Usage,Production

Uses

Spiroxatrine (R 5188) is a SR-1A antagonist.

Definition

ChEBI: 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one is a member of imidazolidines.

Biological Activity

5-HT 1A antagonist. More active and selective than spiperone. Also a very potent α 2C adrenergic receptor antagonist.

in vivo

Spiroxatrine (1-25 ug for i.p., 5 days) increases hindpaw withdrawal latencies to thermal and mechanical stimulation in the nerve injury rat and Carrageenan (HY-125474)-induced rat inflammation model[3].
Spiroxatrine (4 mg/kg/day for i.p., 5 mins) increases the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats [4].

Animal Model:The nerve injury rat model and Carrageenan (HY-125474)-induced rat inflammation model[3]
Dosage:1, 10, 25 ug, 5 days
Administration:Intraperitoneal injection (i.p.)
Result:Increased hindpaw withdrawal latencies to thermal and mechanical stimulation.
Animal Model:Fluoxetine (HY-B0102) -induced reduction of ethanol Intake by the P Line of rats[4]
Dosage:4 mg/kg/day, 5 mins
Administration:Intraperitoneal injection (i.p.)
Result:Increased the voluntary oral ethanol intake induced by Fluoxetine (HY-B0102) in the selectively bred alcohol-preferring P line of rats.

IC 50

α2-adrenergic receptor; 5-HT1A Receptor: 3.94 nM (Ki); 5-HT1B/D Receptor: 224000 nM (Ki); 5-HT2 Receptor: 118.5 nM (Ki)

SPIROXATRINE Preparation Products And Raw materials

Raw materials

Preparation Products

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SPIROXATRINE Suppliers

China 32 Germany 2 Switzerland 3 United Kingdom 2 United States 9 USA 1 Global 49
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-81148696 +86-17392712697
Email
1022@dideu.com
Country
China
ProdList
3995
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
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View Lastest Price from SPIROXATRINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
SPIROXATRINE 1054-88-2
Price
US $0.10/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10
Release date
2024-07-07

1054-88-2, SPIROXATRINERelated Search:

2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYLAMINE Piperoxan 4-(DIETHYLAMINO)BUTYLAMINE 2-Isopropoxyphenol 3-PIPERIDINO-1,2-PROPANEDIOL N-(1-METHYLPIPERIDIN-4-YL)ANILINE SPIROXATRINE Hexahydroisonicotinamide (1-Methyl-4-piperidinyl)methanamine 2-(2-Methoxyphenoxy)ethylamine 1,3-Propanediamine,N3,N3-dimethyl-1-phenyl- N-(2-Hydroxyethyl)-1,4-butanediamine 1-METHYLPIPERIDINE-4-CARBALDEHYDE 1,4-Benzodioxan 2-methyl-1,4-diaminobutane 1,4-BENZODIOXAN-2-METHYLAMINE, N-METHYL- CHEMBRDG-BB 4009655 1-[1-(2-METHOXYETHYL)PIPERIDIN-4-YL]METHANAMINE

  • SPIROXATRINE
  • R 5188
  • (+/-)-8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZA-SPIRO[4,5]DECAN-4-ONE
  • 8-[(2,3-DIHYDRO-1,4-BENZODIOXIN-2-YL)METHYL]-1-PHENYL-1,3,8-TRIAZASPIRO[4,5]DECAN-4-ONE
  • SPIROXATRINE (R 5188) SELECTIVE SEROTONI N 5
  • R 5188, (±)-8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triaza-spiro[4,5]decan-4-one
  • Spiroxatrine (R 5188)
  • 8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
  • 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-
  • 8-((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
  • 1054-88-2
  • Serotonin receptor