NOD1 ANTIBODY
Source Reactivity Background References- Product Name
- NOD1 ANTIBODY
- Chemical Name
- NOD1 ANTIBODY
- Synonyms
- NOD1 ANTIBODY
- CBNumber
- CB04730996
- Formula Weight
- 0
- MOL File
- Mol file
NOD1 ANTIBODY Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria. It contains an amino-terminal caspase recruitment domain that is linked to a central nucleotide-binding domain and is followed by carboxy-terminal leucine-rich repeats. Like Apaf-1, Nod1 induces apoptosis by a CARD/NBD-dependent activation of caspase-9. The primary function of Nod1 is thought to be as a sensor for certain pathogenic microbes and triggering inflammatory responses including the activation of NF-κB and JNK pathways. The LRR of Nod1 appears to be involved in recognition of microbial components and the CARD domain induces NF-κB activation in cooperation with the CARD containing kinase, RICK/RIP2/CARDIAK. Mutations in Nod1 have been linked increased susceptibility to asthma and inflammatory bowel disease.
References
[1] Inohara, N. et al. (1999) J. Biol. Chem. 274, 14560-14567.
[2] Inohara, N. and Nuñez, G. (2003) Nat. Rev. Immunol. 3, 371-382.
[3] Fritz, J.H. et al. (2006) Nat .Immunol. 7, 1250-1257.
[4] Girardin, S.E. et al. (2001) EMBO Rep. 2, 736-742.
[5] Inohara, N. et al. (2001) J. Biol. Chem. 276, 2551-2554.
[6] Inohara, N. et al. (2000) J. Biol. Chem. 275, 27823-27831.
[7] Hysi, P. et al. (2005) Hum. Mol. Genet. 14, 935-941.
[8] McGovern, D.P. et al. (2005) Hum. Mol. Genet. 14, 1245-1250.
NOD1 ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
NOD1 ANTIBODY Suppliers
- Tel
- 021-38015121 18438616290
- lanwu@univ-bio.com
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 18007124176 19384116026
- 2706668885@qq.com
- Country
- China
- ProdList
- 4987
- Advantage
- 58
- Tel
- 400821347
- orders@novusbio.com
- Country
- China
- ProdList
- 6433
- Advantage
- 58
- Tel
- 027-19371278702 18008634902
- nuodina88@163.com
- Country
- China
- ProdList
- 3011
- Advantage
- 58
- Tel
- 0755-26755892 1-949-553-1900
- international@genetex.com
- Country
- China
- ProdList
- 6092
- Advantage
- 58
- Tel
- 858.663.9055 8586639055
- NSJBioname@qq.com
- Country
- China
- ProdList
- 6941
- Advantage
- 58
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
- 6174
- Advantage
- 58
- Tel
- 18886812933
- sales@biosynth.com
- Country
- China
- ProdList
- 6218
- Advantage
- 58
- Tel
- 21-80243558 86218024
- info@cellsignal.cn
- Country
- China
- ProdList
- 6725
- Advantage
- 58
- Tel
- 4006-123-828 13162017139
- market@ab-mart.com
- Country
- China
- ProdList
- 6917
- Advantage
- 58