HUWENTOXIN XVI
- Product Name
- HUWENTOXIN XVI
- CAS No.
- 1600543-88-1
- Chemical Name
- HUWENTOXIN XVI
- Synonyms
- Cys8-Cys21;Cys15-Cys36);HUWENTOXIN XVI;H-Cys-Ile-Gly-Glu-Gly-Val-Pro-Cys-Asp-Glu-Asn-Asp-Pro-Arg-Cys-Cys-Ser-Gly-Leu-Val-Cys-Leu-Lys-Pro-Thr-Leu-His-Gly-Ile-Trp-Tyr-Lys-Ser-Tyr-Tyr-Cys-Tyr-Lys-Lys-OH(Disulfide bridge：Cys1-Cys16
- CBNumber
- CB04733856
- Molecular Formula
- C196H292N50O56S6
- Formula Weight
- 0
- MOL File
- Mol file
HUWENTOXIN XVI Property
- storage temp.
- Store at -20°C
- solubility
- Soluble to 1 mg/ml in H2O
- form
- solid
- color
- White
- Water Solubility
- Soluble to 1 mg/ml in water
N-Bromosuccinimide Price
- Product number
- 255472
- Product name
- Huwentoxin XVI
- Packaging
- 100ug
- Price
- $573
- Updated
- 2021/12/16
HUWENTOXIN XVI Chemical Properties,Usage,Production
Biological Activity
huwentoxin xvi(hwtx-xvi ) is composed of 39 amino acid residues including six cysteines. hwtx-xvi is a novel neurotoxin from the venom of chinese tarantula o. huwena. and specificially block n-type calcium channels. [1]n-type calcium channels are often highly expressed both in dorsal root ganglia cell bodies and in the synaptic terminals projecting to dorsal horn of the spinal cord n-type calcium channels play important roles in the control of neurotransmission release and transmission of pain signals to the central nervous system.[2]electrophysiological assay indicated that hwtx-xvi specifically inhibited n-type calcium channels in rat dorsal root ganglion cells. hwtx-xvi specifically inhibits gvia sensitive, n-type calcium channels in rat drg cells.[1]hwtx-xvi could almost completely block the twitch response of rat vas deferens to low-frequency electrical stimulation. hwtx-xvi ‘s analgesic effects, non-toxic and complete reversibility make it an interesting tool for developing novel drugs for the treatment of n-type calcium channel-related diseases.[1,2]
References
[1] deng m, luo x, xiao y etal. , huwentoxin-xvi, an analgesic, highly reversible mammalian n-type calcium channel antagonist from chinese tarantula ornithoctonus huwena. neuropharmacology. 2014 apr;79:657-67.
[2] liu z, dai j, dai l etal. , function and solution structure of huwentoxin-x, a specific blocker of n-type calcium channels, from the chinese bird spider ornithoctonus huwena. j biol chem. 2006 mar 31;281(13):8628-35.