ChemicalBook > CAS DataBase List > FMOC-D-ASP-OH

FMOC-D-ASP-OH

Product Name: FMOC-D-ASP-OH
CAS No.: 136083-57-3
Chemical Name: FMOC-D-ASP-OH
Synonyms: Fmoc-D-Asp;FMOC-D-ASP-OH;FMOC-D-ASPARTIC ACID;N-FMOC-D-ASPARTIC ACID;FMOC-D-ASP-OH USP/EP/BP;Fmoc-D-aspartic acid≥ 97% (HPLC);N-Fmoc-D-aspartic Acid Fmoc-D-Asp-OH;(9H-Fluoren-9-yl)MethOxy]Carbonyl D-Asp-OH;N-(9-FLUORENYLMETHOXYCARBONYL)-D-ASPARTIC ACID;N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-D-ASPARTIC ACID
CBNumber: CB0476054
Molecular Formula: C19H17NO6
Formula Weight: 355.34
MOL File: 136083-57-3.mol

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FMOC-D-ASP-OH Property

Boiling point:: 587.2±45.0 °C(Predicted)
Density: 1.399±0.06 g/cm3(Predicted)
refractive index: 29 ° (C=1, DMF)
storage temp.: Sealed in dry,2-8°C
pka: 3.66±0.23(Predicted)
form: powder to crystal
color: White to Almost white
CAS DataBase Reference: 136083-57-3(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29225090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0592
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-aspartic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: F0592
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-aspartic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $79
Updated: 2025/07/31

TRC

Product number: F621000
Product name: N-Fmoc-D-asparticAcid
Packaging: 10g
Price: $165
Updated: 2021/12/16

Activate Scientific

Product number: AS102685
Product name: Fmoc-D-aspartic acid
Purity: 95% ee
Packaging: 25g
Price: $206
Updated: 2021/12/16

AK Scientific

Product number: G024
Product name: Fmoc-D-Asp-OH
Packaging: 25g
Price: $217
Updated: 2021/12/16

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FMOC-D-ASP-OH Chemical Properties,Usage,Production

Chemical Properties

White to light yellow solid

Uses

N-Fmoc-D-aspartic acid is an N-Fmoc-protected form of D-Aspartic acid (A790020). D-Aspartic acid is the unnatural isomer of L-Aspartic acid (A790024). D-Aspartic acid naturally occurs in human ovarian follicular fluid, and is thought to be linked to oocyte quality. It is also found in the white matter of human brains, more specifically in myelin proteins.

Synthesis

56-84-8

102774-86-7

136083-57-3

1. 3.03 g (22.8 mmol, 1.2 equiv) L-aspartic acid was dissolved in 54 mL (68.8 mmol, 3.6 equiv) of 13.5% (m/v) aqueous sodium carbonate in a 250 mL dry round bottom flask. 2. The reaction medium was cooled in an ice bath at 0°C, followed by the addition of 6.41 g (19.0 mmol, 1 equiv) of N-(9-fluorenylmethoxycarbonyloxy)succinimide (N-Fmoc) solution dissolved in 44 mL of DMF. 3. The reaction mixture was stirred vigorously (precipitate formed in the reaction medium) and stirring was continued for 1 hour at ambient temperature. 4. The reaction mixture was diluted with 665 mL of water and extracted sequentially with ether (1 x 80 mL) and ethyl acetate (2 x 60 mL). 5. The aqueous phase was cooled in an ice bath and acidified with concentrated hydrochloric acid (6 N) to pH 2, at which point the product precipitated as an oil. 6. The aqueous phase containing the precipitated product was extracted with ethyl acetate (6 x 60 mL). 7. The organic phases were combined and washed sequentially with saturated aqueous sodium chloride solution (3 x 35 mL) and water (2 x 35 mL), followed by drying with sodium sulfate. 8. Concentrate the organic phase to a small volume in a rotary evaporator (35°C). 9. recrystallize Fmoc-D-aspartic acid by addition of about 10 times the volume of petroleum ether (stirring vigorously). 10. The mixture was allowed to stand at 4°C for 2 hours to facilitate separation, after which the precipitate was collected by filtration and dried in a vacuum oven for 24 hours. 11. 6.22 g (17.5 mmol) of Fmoc-D-aspartic acid was obtained as a fine white powder in 92% yield. 12. 12. Product characterization: empirical formula C19H17NO6, molecular weight 355.35 g/mol, melting point 181°C. TLC analysis (Rf = 0.8, eluent: 60% AcOH/BuOH 4/6 v/v). ESI-MS+: m/z 378.1 [M + Na]+ (calculated value C17H17NO6Na: 378.1). 1H-NMR and 13C NMR. NMR and 13C NMR data are consistent with the structure.

References

[1] Patent: US2007/142324, 2007, A1. Location in patent: Page/Page column 8

FMOC-D-ASP-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from FMOC-D-ASP-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-D-Asp-OH 136083-57-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-10-07

Zhuozhou Wenxi import and Export Co., Ltd

Product: FMOC-D-ASP-OH 136083-57-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: FMOC-D-ASP-OH 136083-57-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: g/kg/T
Release date: 2019-12-18

136083-57-3, FMOC-D-ASP-OHRelated Search:

Fmoc-L-4-Iodophenylalanine FMOC-D-NLE-OH Fmoc-L-beta-homoproline Fmoc-O-trityl-L-threonine FMOC-L-2-(5-BROMOTHIENYL)ALANINE FMOC-ASP-OME Fmoc-L-beta-homoisoleucine FMOC-L-STYRYLALANINE FMOC-D-alanine FMOC-PIPERAZINE HYDROCHLORIDE Fmoc-L-citrulline Nalpha-Fmoc-L-tyrosine FMOC-4-CARBOXYMETHYL-PIPERIDINE Fmoc-L-beta-homovaline FMOC-D-ASP-OTBU FMOC-L-ASP(OH)-OAL FMOC-L-ASP-OH,Fmoc-DL-Asp-OH FMOC-D-ASP-OH

FMOC-D-ASP-OH

Fmoc-D-Asp

D-Aspartic acid,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-

(R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)succinic acid

N-Fmoc-D-aspartic Acid Fmoc-D-Asp-OH

(2R)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}butanedioic acid

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-<small>D</small>-aspartic Acid

Fmoc-D-aspartic acid≥ 97% (HPLC)

(9H-Fluoren-9-yl)MethOxy]Carbonyl D-Asp-OH

FMOC-D-ASPARTIC ACID

N-FMOC-D-ASPARTIC ACID

N-(9-FLUORENYLMETHOXYCARBONYL)-D-ASPARTIC ACID

N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-D-ASPARTIC ACID

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-ASPARATIC ACID

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparticAcid&gt

(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanedioicaci

FMOC-D-ASP-OH USP/EP/BP

136083-57-3

Aspartic acid [Asp, D]

Amino Acids

Amino Acids (N-Protected)

Biochemistry

Fmoc-Amino Acids