DL-THIORPHAN
- Product Name
- DL-THIORPHAN
- CAS No.
- 76721-89-6
- Chemical Name
- DL-THIORPHAN
- Synonyms
- C01619;THIORPHAN;Thiorphan-d5;DL-THIORPHAN;THIORPHAN (DL);DL-THIORPHAN USP/EP/BP;Bisoprolol FuMarate IMpurity-Q;(DL-3-MERCAPTO-2-BENZYLPROPANOYL)-GLY;(2-benzyl-3-mercaptopropanoyl)glycine;DL-3-MERCAPTO-2-BENZYLPROPANOYL-GLYCINE
- CBNumber
- CB0479626
- Molecular Formula
- C12H15NO3S
- Formula Weight
- 253.32
- MOL File
- 76721-89-6.mol
DL-THIORPHAN Property
- Melting point:
- 138-140 °C
- Boiling point:
- 524.0±50.0 °C(Predicted)
- Density
- 1.246±0.06 g/cm3(Predicted)
- RTECS
- MC0596440
- storage temp.
- -15°C
- solubility
- ethanol: 50 mg/mL, clear, colorless
- form
- White solid
- pka
- 3.48±0.10(Predicted)
- color
- White to Off-White
- BRN
- 4872101
- CAS DataBase Reference
- 76721-89-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T6031
- Product name
- DL-Thiorphan
- Purity
- ≥98% (TLC)
- Packaging
- 5mg
- Price
- $219
- Updated
- 2024/03/01
- Product number
- 598510
- Product name
- DL-Thiorphan
- Packaging
- 10mg
- Price
- $378
- Updated
- 2023/01/07
- Product number
- J62557
- Product name
- DL-Thiorphan
- Packaging
- 25mg
- Price
- $459.65
- Updated
- 2024/03/01
- Product number
- 15600
- Product name
- Thiorphan
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 15600
- Product name
- Thiorphan
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
DL-THIORPHAN Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
An Enkephalinase inhibitor
Uses
Thiorphan is a potent inhibitor of neprilysin, a membrane metallo-endopeptidase that cleaves peptide hormones, such as enkephalins, glucagon, and bradykinin (Ki = 4-140 nM). It is much less effective against neprilysin-2 (IC50 = 22.1 μM), angiotensin-converting enzyme, and endothelin-converting enzyme-1. Thiorphan can be produced in vivo via the metabolism of the prodrug acetorphan. Neprilysin is overexpressed in many forms of cancer and may play a role in protecting against Alzheimer’s disease.
Uses
DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.
Uses
The active metabolite
Definition
ChEBI: Thiorphan is a N-acyl-amino acid.
General Description
A thiol-containing amido-acid that selectively binds to the active site zinc of neprilysin (also known as neutral endopeptidase and NEP) and inhibits its activity (IC50 = 2.1 nM). Inhibits the β-amyloid (Aβ) degrading activity of neprilysin in vivo, but does not affect the secretion of either Aβ peptide or amyloid precursor protein (APP). Also shown to inhibit other neprilysin-related family members, such as mouse NL1 (IC50 = 47 nM) and the neprilysin homolog from Ascaris suum (IC50 = 22 μM). Inhibits the activity of angiotensin-converting enzyme (ACE) (IC50 = 140 nM), but has no effect on the activity of endothelin-converting enzyme (ECE).
Biochem/physiol Actions
Primary TargetNEP activity
DL-THIORPHAN Preparation Products And Raw materials
Raw materials
Preparation Products
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