E-7386

Product Name: E-7386
CAS No.: 1799824-08-0
Chemical Name: E-7386
Synonyms: E-7386, 10 mM in DMSO;E-7386,Epigenetic Reader Domain,E 7386,inhibit,Inhibitor;(6S,9aS)-2-Allyl-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide;2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, 8-[[6-[3-(4-ethyl-1-piperazinyl)-1-azetidinyl]-2-pyridinyl]methyl]-6-[(2-fluoro-4-hydroxyphenyl)methyl]hexahydro-4,7-dioxo-N-(phenylmethyl)-2-(2-propen-1-yl)-, (6S,9aS)-
CBNumber: CB04796648
Molecular Formula: C39H48FN9O4
Formula Weight: 725.85
MOL File: 1799824-08-0.mol

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E-7386 Property

Density: 1.39±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:125.0(Max Conc. mg/mL);172.21(Max Conc. mM)
form: Solid
pka: 8.92±0.20(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: E102405
Product name: E-7386
Packaging: 1mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-0040308
Product name: E-7386
Purity: 99.95%
Packaging: 5mg
Price: $330
Updated: 2021/12/16

ChemScene

Product number: CS-0040308
Product name: E-7386
Purity: 99.95%
Packaging: 10mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0040308
Product name: E-7386
Purity: 99.95%
Packaging: 50mg
Price: $1500
Updated: 2021/12/16

ChemScene

Product number: CS-0040308
Product name: E-7386
Purity: 99.95%
Packaging: 1mg
Price: $110
Updated: 2021/12/16

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E-7386 Chemical Properties,Usage,Production

Uses

E-7386, is an CBP/beta-catenin modulator that is shown to be orally active. E-7386, has shown high antitumor activity in Wnt1 model.

in vivo

E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group^[1].

E-7386 Preparation Products And Raw materials

Raw materials

Preparation Products

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E-7386 Suppliers

China 34 United States 3 Global 37

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1136
Advantage: 64

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Email: 2819742715@qq.com
Country: China
ProdList: 3998
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

DKMbiochem.Co. Ltd

Tel: 15901859516
Fax: 15901859516
Email: sales@DKMbiochem.com
Country: China
ProdList: 344
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7777
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4818
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9482
Advantage: 58

Heze Development Zone chuangli Chemical Co., Ltd.

Tel: 0530-+86-530-529 6766，+86-15666160102 15666160102
Fax: 0530-529 6766
Email: info@chuangli-chem.com
Country: China
ProdList: 840
Advantage: 55

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

1799824-08-0, E-7386Related Search:

2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, 8-[[6-[3-(4-ethyl-1-piperazinyl)-1-azetidinyl]-2-pyridinyl]methyl]-6-[(2-fluoro-4-hydroxyphenyl)methyl]hexahydro-4,7-dioxo-N-(phenylmethyl)-2-(2-propen-1-yl)-, (6S,9aS)-

E-7386,Epigenetic Reader Domain,E 7386,inhibit,Inhibitor

(6S,9aS)-2-Allyl-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide

E-7386, 10 mM in DMSO

1799824-08-0

C39H48FN9O4