ChemicalBook > CAS DataBase List > E-7386
E-7386
- Product Name
- E-7386
- CAS No.
- 1799824-08-0
- Chemical Name
- E-7386
- Synonyms
- E-7386, 10 mM in DMSO;E-7386,Epigenetic Reader Domain,E 7386,inhibit,Inhibitor;(6S,9aS)-2-Allyl-N-benzyl-8-((6-(3-(4-ethylpiperazin-1-yl)azetidin-1-yl)pyridin-2-yl)methyl)-6-(2-fluoro-4-hydroxybenzyl)-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide;2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, 8-[[6-[3-(4-ethyl-1-piperazinyl)-1-azetidinyl]-2-pyridinyl]methyl]-6-[(2-fluoro-4-hydroxyphenyl)methyl]hexahydro-4,7-dioxo-N-(phenylmethyl)-2-(2-propen-1-yl)-, (6S,9aS)-
- CBNumber
- CB04796648
- Molecular Formula
- C39H48FN9O4
- Formula Weight
- 725.85
- MOL File
- 1799824-08-0.mol
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E-7386 Property
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:125.0(Max Conc. mg/mL);172.21(Max Conc. mM)
- form
- Solid
- pka
- 8.92±0.20(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
TRC
- Product number
- E102405
- Product name
- E-7386
- Packaging
- 1mg
- Price
- $125
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0040308
- Product name
- E-7386
- Purity
- 99.95%
- Packaging
- 5mg
- Price
- $330
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0040308
- Product name
- E-7386
- Purity
- 99.95%
- Packaging
- 10mg
- Price
- $500
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0040308
- Product name
- E-7386
- Purity
- 99.95%
- Packaging
- 50mg
- Price
- $1500
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0040308
- Product name
- E-7386
- Purity
- 99.95%
- Packaging
- 1mg
- Price
- $110
- Updated
- 2021/12/16
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E-7386 Chemical Properties,Usage,Production
Uses
E-7386, is an CBP/beta-catenin modulator that is shown to be orally active. E-7386, has shown high antitumor activity in Wnt1 model.
in vivo
E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group[1].
E-7386 Preparation Products And Raw materials
Raw materials
Preparation Products
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E-7386 Suppliers
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58