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CH7057288

Product Name
CH7057288
CAS No.
2095616-82-1
Chemical Name
CH7057288
Synonyms
CH7057288;Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288;4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
CBNumber
CB04797034
Molecular Formula
C32H31N3O5S
Formula Weight
569.67
MOL File
2095616-82-1.mol
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CH7057288 Property

Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:34.0(Max Conc. mg/mL);59.68(Max Conc. mM)
form 
Solid
pka
6.89±0.40(Predicted)
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
25mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
50mg
Price
$1750
Updated
2021/12/16
ChemScene
Product number
CS-0028214
Product name
CH7057288
Purity
98.52%
Packaging
100mg
Price
$2750
Updated
2021/12/16
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CH7057288 Chemical Properties,Usage,Production

Biological Activity

CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.

in vitro

In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> TrkB
(Cell-free assay)
TargetValue
TrkA
(Cell-free assay)		 1.1 nM
TrkC
(Cell-free assay)		 5.1 nM
7.8 nM

CH7057288 Preparation Products And Raw materials

Raw materials

Preparation Products

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CH7057288 Suppliers

CHINA 34 United States 4 Global 38
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7787
Advantage
56
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4574
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2993
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9952
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29764
Advantage
68
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1925
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58

2095616-82-1, CH7057288Related Search:


  • CH7057288
  • 4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
  • Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288
  • 2095616-82-1