ChemicalBook > CAS DataBase List > CH7057288
CH7057288
- Product Name
- CH7057288
- CAS No.
- 2095616-82-1
- Chemical Name
- CH7057288
- Synonyms
- CH7057288;CH7057288, 10 mM in DMSO;Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288;4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
- CBNumber
- CB04797034
- Molecular Formula
- C32H31N3O5S
- Formula Weight
- 569.67
- MOL File
- 2095616-82-1.mol
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CH7057288 Property
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:34.0(Max Conc. mg/mL);59.68(Max Conc. mM)
- form
- Solid
- pka
- 6.89±0.40(Predicted)
- color
- Off-white to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 25mg
- Price
- $1100
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 50mg
- Price
- $1750
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 100mg
- Price
- $2750
- Updated
- 2021/12/16
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CH7057288 Chemical Properties,Usage,Production
Uses
CH7057288 is a potent and selective TRK inhibitor. CH7057288 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Biological Activity
CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
in vitro
In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways.
target
| Target | Value |
| TrkA (Cell-free assay) | 1.1 nM |
| TrkC (Cell-free assay) | 5.1 nM |
| 7.8 nM |
IC 50
TRK
References
[1] Hiroshi Tanaka, et al. Abstract 4179: Potent and selective TRK inhibitor CH7057288. AACR Annual Meeting 2017; April 1-5, 2017.
CH7057288 Preparation Products And Raw materials
Raw materials
Preparation Products
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