CH7057288

ChemicalBook > CAS DataBase List > CH7057288

Product Name: CH7057288
CAS No.: 2095616-82-1
Chemical Name: CH7057288
Synonyms: CH7057288;CH7057288, 10 mM in DMSO;Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288;4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
CBNumber: CB04797034
Molecular Formula: C32H31N3O5S
Formula Weight: 569.67
MOL File: 2095616-82-1.mol

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CH7057288 Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:34.0(Max Conc. mg/mL);59.68(Max Conc. mM)
form: Solid
pka: 6.89±0.40(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0028214
Product name: CH7057288
Purity: 98.52%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0028214
Product name: CH7057288
Purity: 98.52%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0028214
Product name: CH7057288
Purity: 98.52%
Packaging: 25mg
Price: $1100
Updated: 2021/12/16

ChemScene

Product number: CS-0028214
Product name: CH7057288
Purity: 98.52%
Packaging: 50mg
Price: $1750
Updated: 2021/12/16

ChemScene

Product number: CS-0028214
Product name: CH7057288
Purity: 98.52%
Packaging: 100mg
Price: $2750
Updated: 2021/12/16

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CH7057288 Chemical Properties,Usage,Production

Biological Activity

CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.

in vitro

In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> TrkB
(Cell-free assay)

Target	Value
TrkA (Cell-free assay)	1.1 nM
TrkC (Cell-free assay)	5.1 nM
7.8 nM

CH7057288 Preparation Products And Raw materials

Raw materials

Preparation Products

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2095616-82-1, CH7057288Related Search:

CH7057288

4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-

Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288

CH7057288, 10 mM in DMSO

2095616-82-1