ChemicalBook > CAS DataBase List > CH7057288
CH7057288
- Product Name
- CH7057288
- CAS No.
- 2095616-82-1
- Chemical Name
- CH7057288
- Synonyms
- CH7057288;Inhibitor,Trk Receptor,CH7057288,inhibit,Tropomyosin related kinase receptor,CH 7057288,CH-7057288;4-Pyridinecarboxamide, 2-[2-[6,11-dihydro-6,6-dimethyl-8-[(methylsulfonyl)amino]-11-oxobenzo[b]naphtho[2,3-d]furan-3-yl]ethynyl]-N-(1,1-dimethylethyl)-6-methyl-
- CBNumber
- CB04797034
- Molecular Formula
- C32H31N3O5S
- Formula Weight
- 569.67
- MOL File
- 2095616-82-1.mol
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CH7057288 Property
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:34.0(Max Conc. mg/mL);59.68(Max Conc. mM)
- pka
- 6.89±0.40(Predicted)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 25mg
- Price
- $1100
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 50mg
- Price
- $1750
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0028214
- Product name
- CH7057288
- Purity
- 98.52%
- Packaging
- 100mg
- Price
- $2750
- Updated
- 2021/12/16
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CH7057288 Chemical Properties,Usage,Production
Biological Activity
CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
in vitro
In cell-free kinase assays, CH7057288 has selective inhibitory activity against TRKA, TRKB and TRKC, and inhibits the proliferation of cells containing TRK fusions. It inhibits MAPK and E2F signaling pathways.
target
Target | Value |
TrkA (Cell-free assay) | 1.1 nM |
TrkC (Cell-free assay) | 5.1 nM |
7.8 nM |
CH7057288 Preparation Products And Raw materials
Raw materials
Preparation Products
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