DJ-V159
- Product Name
- DJ-V159
- CAS No.
- 2253744-53-3
- Chemical Name
- DJ-V159
- Synonyms
- DJ-V159;DJ-V159;DJ-V 159;DJ-V-159, 10 mM in DMSO;DJV159,Inhibitor,Androgen Receptor,inhibit,DJ V 159;1,3-Benzenedicarboxamide, N1,N3-bis[4-cyano-3-(trifluoromethyl)phenyl]-
- CBNumber
- CB04804691
- Molecular Formula
- C24H12F6N4O2
- Formula Weight
- 502.37
- MOL File
- 2253744-53-3.mol
DJ-V159 Property
- storage temp.
- RT
- solubility
- Soluble in DMSO (up to 60 mg/ml).
- form
- solid
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase? as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 6645
- Product name
- DJ-V159
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $109
- Updated
- 2021/12/16
- Product number
- orb573178
- Product name
- DJ-V-159
- Purity
- >98%
- Packaging
- 100mg
- Price
- $838.1
- Updated
- 2021/12/16
- Product number
- orb573178
- Product name
- DJ-V-159
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1431.4
- Updated
- 2021/12/16
- Product number
- orb573178
- Product name
- DJ-V-159
- Purity
- >98%
- Packaging
- 1g
- Price
- $2691.1
- Updated
- 2021/12/16
- Product number
- DC12040
- Product name
- DJ-V-159
- Purity
- >98%
- Packaging
- 1g
- Price
- $1800
- Updated
- 2021/12/16
DJ-V159 Chemical Properties,Usage,Production
Description
GPRC6A? is the receptor for osteocalcin as well as structurally unrelated ligands including L-amino acids, cations and anabolic steroids.1?GPRC6A is a potential therapeutic target for treating type 2 diabetes.2 DJ-V 159 (2253744-53-3) is an agonist at GPRC6A which activates ERK and upregulates cAMP levels in HEK-193 cells expressing GPRC6A. It stimulates insulin secretion in mouse β-cells and lowers blood glucose in mouse models.3
Uses
DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).
in vivo
DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five[1].
storage
Store at RT
References
[1] MIN PI L D Q. Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks.[J]. Endocrinology, 2012, 153 5: 2062-2069. DOI:10.1210/en.2011-2117
[2] MIN PI L. D Q Satoru Kenneth Nishimoto. GPRC6A: Jack of all metabolism (or master of none)[J]. Molecular Metabolism, 2017, 6 2: Pages 185-193. DOI:10.1016/j.molmet.2016.12.006
[3] MIN PI. Computationally identified novel agonists for GPRC6A.[J]. PLoS ONE, 2018: e0195980. DOI:10.1371/journal.pone.0195980
DJ-V159 Preparation Products And Raw materials
Raw materials
Preparation Products
DJ-V159 Suppliers
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