4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE

Product Name: 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE
CAS No.: 30235-28-0
Chemical Name: 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE
Synonyms: BUTTPARK 37\12-54;IFLAB-BB F0537-0969;4-(4-pyridyl)thiazol-2-amine;4-(4-pyridyl)-2-thiazolamine;2-AMINO-4-(4-PYRIDYL)THIAZOLE;4-pyridin-4-yl-2-thiazolamine;4-(4-PYRIDINYL)-2-THIAZOLAMINE;[4-(4-pyridyl)thiazol-2-yl]amine;4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE;2-Thiazolamine, 4-(4-pyridinyl)-
CBNumber: CB0480505
Molecular Formula: C8H7N3S
Formula Weight: 177.23
MOL File: 30235-28-0.mol

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4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE Property

Melting point:: 270-272 °C
Boiling point:: 378.9±17.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMF: 5 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: 0.14 mg/ml
form: A crystalline solid
pka: 2.89±0.10(Predicted)
Sensitive: Air Sensitive
CAS DataBase Reference: 30235-28-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11058
Product name: 2-amino-4-(4-pyridyl)-Thiazole
Purity: ≥97%
Packaging: 1g
Price: $126
Updated: 2024/03/01

Cayman Chemical

Product number: 11058
Product name: 2-amino-4-(4-pyridyl)-Thiazole
Purity: ≥97%
Packaging: 5g
Price: $516
Updated: 2024/03/01

Cayman Chemical

Product number: 11058
Product name: 2-amino-4-(4-pyridyl)-Thiazole
Purity: ≥97%
Packaging: 500mg
Price: $66
Updated: 2024/03/01

TRC

Product number: B525603
Product name: 4-Pyridin-4-yl-1,3-thiazol-2-amine
Packaging: 5g
Price: $440
Updated: 2021/12/16

AK Scientific

Product number: 9519AD
Product name: 4-Pyridin-4-yl-thiazol-2-ylamine
Packaging: 5g
Price: $291
Updated: 2021/12/16

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4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE Chemical Properties,Usage,Production

Uses

4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE is a synthetic intermediate useful for pharmaceutical synthesis.

Synthesis

5349-17-7

17356-08-0

30235-28-0

General procedure for the synthesis of 4-(pyridin-4-yl)thiazol-2-amines from 4-(bromoacetyl)pyridine hydrobromide and thiourea: Synthesis of batch 1: A mixture of 4-(bromoacetyl)pyridine hydrobromide (2.21 g, 7.90 mmol) and thiourea (0.60 g, 7.90 mmol) in anhydrous ethanol (10 mL) was subjected to stirring in a Biotage microwave reactor at 100°C for 30 min. After completion of the reaction, it was cooled to room temperature, the solid precipitate was collected by filtration and dried under vacuum. Synthesis of batch 2: A mixture of 4-(bromoacetyl)pyridine hydrobromide (2.54 g, 9.06 mmol) and thiourea (0.69 g, 9.06 mmol) in anhydrous ethanol (10 mL) was placed in a Biotage microwave reactor and the reaction was stirred for 30 minutes at 100°C. The reaction was cooled to room temperature and the solid precipitate was collected by filtration. After completion of the reaction, it was cooled to room temperature, the solid precipitate was collected by filtration and dried under vacuum. Synthesis of batch 3: A mixture of 4-(bromoacetyl)pyridine hydrobromide (2.16 g, 7.73 mmol) and thiourea (0.58 g, 7.73 mmol) in anhydrous ethanol (10 mL) was placed in a Biotage microwave reactor and the reaction was stirred for 30 minutes at 100°C. The reaction was cooled to room temperature and the solid precipitate was collected by filtration. After completion of the reaction, it was cooled to room temperature, the solid precipitate was collected by filtration and dried under vacuum. The products of batches 1, 2 and 3 were combined and suspended in saturated aqueous sodium bicarbonate solution. Filtered, washed with sodium bicarbonate solution and dried under vacuum to afford the title compound 4-(pyridin-4-yl)thiazol-2-amine as a pale pink solid (5.53 g, 31.27 mmol, 95% yield).1H NMR (400 MHz, CD3OD) δ 8.49 (d, J = 6.3 Hz, 2H), 7.79 (d, J = 6.3 Hz, 2H) , 7.25 (s, 1H).

References

[1] MedChemComm, 2012, vol. 3, # 6, p. 699 - 709
[2] Patent: WO2011/130740, 2011, A2. Location in patent: Page/Page column 42
[3] Patent: WO2012/125981, 2012, A2. Location in patent: Page/Page column 131
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 2, p. 787 - 797
[5] Patent: WO2009/114552, 2009, A1. Location in patent: Page/Page column 133

4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE Suppliers

Canada 1 China 91 Germany 2 India 3 Russia 4 Ukraine 1 United Kingdom 7 United States 17 Global 126

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View Lastest Price from 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE 30235-28-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE 30235-28-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

30235-28-0, 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINERelated Search:

4-(4-pyridyl)-2-thiazolamine

4-(4-pyridyl)thiazol-2-amine

4-(4-Pyridinyl)-1,3-thiazol-2-amine

[4-(4-pyridyl)thiazol-2-yl]amine

4-Pyridin-4-Yl-Thiazol-2-Ylamine(WX609272)

2-AMINO-4-(4-PYRIDYL)THIAZOLE

4-PYRIDIN-4-YL-1,3-THIAZOL-2-AMINE

4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE

4-(4-PYRIDINYL)-1,3-THIAZOL-2-YLAMINE

4-(Pyridin-4-yl)thiazol-2-amine ,98%

IFLAB-BB F0537-0969

BUTTPARK 37\12-54

2-Amino-4-pyridin-4-yl-1,3-thiazole

4-(4-PYRIDINYL)-2-THIAZOLAMINE

4-pyridin-4-yl-2-thiazolamine

2-Thiazolamine, 4-(4-pyridinyl)-

30235-28-0

Amines

Thiazoles, Isothiazoles & Benzothiazoles