4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE
- Product Name
- 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE
- CAS No.
- 30235-27-9
- Chemical Name
- 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE
- Synonyms
- BUTTPARK 33\12-84;TIMTEC-BB SBB010098;IFLAB-BB F0537-0970;2-AMINO-4-(3-PYRIDYL)THIAZOLE;4-(3-PYRIDINYL)-2-THIAZOLAMINE;4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE;2-Thiazolamine, 4-(3-pyridinyl)-;4-pyridine-3-yl-thiazol-2-ylamine;2-Amino-4-(3-pyridyl)thiazole,97%;4-pyridin-3-yl-1,3-thiazol-2-amine
- CBNumber
- CB8433390
- Molecular Formula
- C8H7N3S
- Formula Weight
- 177.23
- MOL File
- 30235-27-9.mol
4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE Property
- Melting point:
- 213 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 396.3±17.0 °C(Predicted)
- Density
- 1.333±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- Solid
- pka
- 3.33±0.10(Predicted)
- color
- Pale brown
Safety
- Hazard Codes
- Xi
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A576838
- Product name
- 2-Amino-4-(3-pyridyl)thiazole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- W5264
- Product name
- 4-(Pyridin-3-yl)thiazol-2-amine
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 7H30-1-X8
- Product name
- 2-Amino-4-(pyridin-3-yl)-1,3-thiazole
- Packaging
- 1g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- W5264
- Product name
- 4-(Pyridin-3-yl)thiazol-2-amine
- Packaging
- 5g
- Price
- $424
- Updated
- 2021/12/16
- Product number
- CHM0020261
- Product name
- 2-AMINO-4-(3-PYRIDYL)THIAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE Chemical Properties,Usage,Production
Uses
It is used as a pharmaceutical intermediate.
Synthesis
6221-12-1
17356-08-0
30235-27-9
Step 2: Synthesis of 4-(pyridin-3-yl)thiazol-2-amine: 2-bromo-1-(pyridin-3-yl)ethanone (2 g, 1 eq.) was dissolved in ethanol (18.46 mL) followed by addition of thiourea (0.543 g, 0.7 eq.). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was cooled to 4 °C. During this process, the product precipitated as dihydrobromide. The precipitate was collected by filtration and dried. The resulting 4-(pyridin-3-yl)thiazol-2-amine dihydrobromide was dissolved in warm water (11 mL) and stirred for 5 minutes. Subsequently, aqueous ammonium hydroxide solution (17 mL) was added to this solution and stirring was continued. At this point, the target product slowly precipitated as a yellow solid. The solid product was separated by filtration and dried under vacuum conditions to give 2 g of 4-(pyridin-3-yl)thiazol-2-amine in 56% yield. The product was analyzed by LCMS showing m/z of 178.01 (M + H); 1H NMR (400 MHz, CD3OD) data were as follows: δ 8.96 (d, J=0.80 Hz, 1H), 8.44 (dd, J=1.60,4.80 Hz, 1H), 8.19-8.22 (m, 1H), 7.43-7.47 (m, 1H), and 7.05 (s, 1H).
References
[1] Patent: WO2014/74675, 2014, A1. Location in patent: Paragraph 00222
[2] Journal of Heterocyclic Chemistry, 1970, vol. 7, p. 1137 - 1141
[3] Patent: WO2012/82817, 2012, A1. Location in patent: Page/Page column 93-94
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 2, p. 560 - 564
4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE manufacturers
- Product
- 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE 30235-27-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-25
- Product
- 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE 30235-27-9
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-02-04