ChemicalBook > CAS DataBase List > 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE

4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE

Product Name
4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE
CAS No.
30235-27-9
Chemical Name
4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE
Synonyms
BUTTPARK 33\12-84;TIMTEC-BB SBB010098;IFLAB-BB F0537-0970;2-AMINO-4-(3-PYRIDYL)THIAZOLE;4-(3-PYRIDINYL)-2-THIAZOLAMINE;4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE;2-Thiazolamine, 4-(3-pyridinyl)-;4-pyridine-3-yl-thiazol-2-ylamine;2-Amino-4-(3-pyridyl)thiazole,97%;4-pyridin-3-yl-1,3-thiazol-2-amine
CBNumber
CB8433390
Molecular Formula
C8H7N3S
Formula Weight
177.23
MOL File
30235-27-9.mol
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4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE Property

Melting point:
213 °C(Solv: ethanol (64-17-5))
Boiling point:
396.3±17.0 °C(Predicted)
Density 
1.333±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Solid
pka
3.33±0.10(Predicted)
color 
Pale brown
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Safety

Hazard Codes 
Xi
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
A576838
Product name
2-Amino-4-(3-pyridyl)thiazole
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
W5264
Product name
4-(Pyridin-3-yl)thiazol-2-amine
Packaging
1g
Price
$150
Updated
2021/12/16
SynQuest Laboratories
Product number
7H30-1-X8
Product name
2-Amino-4-(pyridin-3-yl)-1,3-thiazole
Packaging
1g
Price
$240
Updated
2021/12/16
AK Scientific
Product number
W5264
Product name
4-(Pyridin-3-yl)thiazol-2-amine
Packaging
5g
Price
$424
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0020261
Product name
2-AMINO-4-(3-PYRIDYL)THIAZOLE
Purity
95.00%
Packaging
2.5G
Price
$983.88
Updated
2021/12/16
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4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE Chemical Properties,Usage,Production

Uses

It is used as a pharmaceutical intermediate.

Synthesis

6221-12-1

17356-08-0

30235-27-9

Step 2: Synthesis of 4-(pyridin-3-yl)thiazol-2-amine: 2-bromo-1-(pyridin-3-yl)ethanone (2 g, 1 eq.) was dissolved in ethanol (18.46 mL) followed by addition of thiourea (0.543 g, 0.7 eq.). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was cooled to 4 °C. During this process, the product precipitated as dihydrobromide. The precipitate was collected by filtration and dried. The resulting 4-(pyridin-3-yl)thiazol-2-amine dihydrobromide was dissolved in warm water (11 mL) and stirred for 5 minutes. Subsequently, aqueous ammonium hydroxide solution (17 mL) was added to this solution and stirring was continued. At this point, the target product slowly precipitated as a yellow solid. The solid product was separated by filtration and dried under vacuum conditions to give 2 g of 4-(pyridin-3-yl)thiazol-2-amine in 56% yield. The product was analyzed by LCMS showing m/z of 178.01 (M + H); 1H NMR (400 MHz, CD3OD) data were as follows: δ 8.96 (d, J=0.80 Hz, 1H), 8.44 (dd, J=1.60,4.80 Hz, 1H), 8.19-8.22 (m, 1H), 7.43-7.47 (m, 1H), and 7.05 (s, 1H).

References

[1] Patent: WO2014/74675, 2014, A1. Location in patent: Paragraph 00222
[2] Journal of Heterocyclic Chemistry, 1970, vol. 7, p. 1137 - 1141
[3] Patent: WO2012/82817, 2012, A1. Location in patent: Page/Page column 93-94
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 2, p. 560 - 564

4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE Suppliers

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View Lastest Price from 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE 30235-27-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-07-25
Career Henan Chemical Co
Product
4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE 30235-27-9
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-02-04

30235-27-9, 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINERelated Search:

Masitinib 4-(6-CHLORO-PYRIDIN-3-YL)-THIAZOL-2-YLAMINE 4-(6-BROMO-2-METHYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-THIAZOL-2-YLAMINE 2-PYRIDIN-4-YL-THIAZOL-4-YLAMINE 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE 4-(2,6-DIMETHYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-THIAZOL-2-YLAMINE 4-PYRIDIN-2-YL-THIAZOL-2-YLAMINE 4-(2-METHYL-IMIDAZO[1,2-A ]PYRIDIN-3-YL)-THIAZOL-2-YLAMINE 4-(6-CHLORO-2-METHYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-THIAZOL-2-YLAMINE 5-METHYL-4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE 4-PYRIDIN-4-YL-THIAZOL-2-YLAMINE 4-(2,8-DIMETHYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-THIAZOL-2-YLAMINE 4-(6-BROMO-2-METHYL-8-NITRO-IMIDAZO[1,2-A]PYRIDIN-3-YL)-THIAZOL-2-YLAMINE 4-(2,7-DIMETHYL-6-NITRO-IMIDAZO[1,2-A]PYRIDIN-3-YL)-THIAZOL-2-YLAMINE 4,5-dihydrothiazolo(4,5-f)quinolin-2-amine 4-(6,8-DICHLORO-2-METHYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-THIAZOL-2-YLAMINE ETHYL 1-[4-(3-PYRIDINYL)-1,3-THIAZOL-2-YL]-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE TIMTEC-BB SBB012307

  • 2-AMINO-4-(3-PYRIDYL)THIAZOLE
  • 4-PYRIDIN-3-YL-THIAZOL-2-YLAMINE
  • 4-(3-PYRIDINYL)-1,3-THIAZOL-2-YLAMINE
  • BUTTPARK 33\12-84
  • IFLAB-BB F0537-0970
  • TIMTEC-BB SBB010098
  • 4-(3-PYRIDINYL)-2-THIAZOLAMINE
  • 4-pyridine-3-yl-thiazol-2-ylamine
  • 2-Thiazolamine, 4-(3-pyridinyl)-
  • 4-(Pyridin-3-yl)-1,3-thiazol-2-amine, 3-(2-Amino-1,3-thiazol-4-yl)pyridine
  • 4-pyridin-3-yl-1,3-thiazol-2-amine
  • 2-Amino-4-(3-pyridyl)thiazole,97%
  • 30235-27-9