ChemicalBook > CAS DataBase List > 4-(DIFLUOROMETHOXY)BENZALDEHYDE

4-(DIFLUOROMETHOXY)BENZALDEHYDE

Product Name: 4-(DIFLUOROMETHOXY)BENZALDEHYDE
CAS No.: 73960-07-3
Chemical Name: 4-(DIFLUOROMETHOXY)BENZALDEHYDE
Synonyms: AKOS B006820;AKOS BBS-00000693;VITAS-BB TBB000651;TIMTEC-BB SBB003837;4-(DIFLUOROMETHOXY)BENZALDEHYDE;p-(difluoromethoxy)benzaldehyde;BENZALDEHYDE,4-(DIFLUOROMETHOXY);4-(Difluoromethoxy)benzaldehyde>4-(Difluoromethoxy)benzaldehyde98%;4-(Difluoromethoxy)benzaldehyde 98%
CBNumber: CB0480530
Molecular Formula: C8H6F2O2
Formula Weight: 172.13
MOL File: 73960-07-3.mol

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4-(DIFLUOROMETHOXY)BENZALDEHYDE Property

Boiling point:: 222 °C (lit.)
Density: 1.302 g/mL at 25 °C (lit.)
refractive index: n20/D 1.503(lit.)
Flash point:: 228 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: clear liquid
color: Colorless to Light yellow
λmax: 256nm(EtOH)(lit.)
Sensitive: Air Sensitive
BRN: 3049286
CAS DataBase Reference: 73960-07-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39-24/25
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29130000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 470112
Product name: 4-(Difluoromethoxy)benzaldehyde
Purity: 95%
Packaging: 5g
Price: $50.5
Updated: 2025/07/31

TCI Chemical

Product number: D4334
Product name: 4-(Difluoromethoxy)benzaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: D4334
Product name: 4-(Difluoromethoxy)benzaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $122
Updated: 2025/07/31

TRC

Product number: D452238
Product name: 4-(Difluoromethoxy)benzaldehyde
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D452238
Product name: 4-(Difluoromethoxy)benzaldehyde
Packaging: 50mg
Price: $60
Updated: 2021/12/16

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4-(DIFLUOROMETHOXY)BENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

light yellow liquid

Uses

4-(Difluoromethoxy)benzaldehyde may be used for the preparation of 4-(4-difluoro-methoxy-phen-yl)-1,2,3,4,5,6,7,8-octa-hydro-quinazoline-2,5-dione, via one-pot three-component reaction with cyclo-hexane-1,3-dione and urea.

General Description

4-(Difluoromethoxy)benzaldehyde is a p-difluoromethoxy substituted benzaldehyde.

Synthesis

75-45-6

123-08-0

73960-07-3

Example 1 Synthesis of 4-(difluoromethoxy)benzaldehyde: In a 1 L four-necked round-bottomed flask equipped with a thermometer, reflux condenser, mechanical stirrer, and gas introduction tube, 50 g (0.41 mol) of p-hydroxybenzaldehyde and 400 mL of isopropanol were added. After stirring the mixture for 20 minutes, 120 mL of a 120 mL aqueous solution containing 5 g of 18-crown-6 ether and 106.3 g (2.665 mol) of sodium hydroxide was slowly added dropwise. After the dropwise addition was completed, stirring was continued for 30 minutes and the mixture was subsequently heated to 65°C. Chlorodifluoromethane was slowly passed through the gas introduction tube over a period of 5-6 hours and the reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to 15 °C and 400 mL of water was added to quench the reaction. The reaction mixture was extracted three times with ether (3 x 300 mL). The organic layers were combined, washed with water to pH=7 and dried over anhydrous magnesium sulfate. The ether was removed by rotary evaporation and the residue was distilled under reduced pressure to collect the 85-87 °C/10 mmHg fraction to give 4-(difluoromethoxy)benzaldehyde in 95% yield.1H-NMR (ppm) δ: 9.87 (1H, s, -CHO); 7.70 (2H, m, 2,6-ArH); 7.36 (1H, t, J2H-F = 68 Hz, - CHF2); 6.96 (2H, m, 3,5-ArH).

References

[1] Patent: US2008/306027, 2008, A1. Location in patent: Page/Page column 7-8
[2] Journal of Organic Chemistry USSR (English Translation), 1992, vol. 28, # 8.1, p. 1317 - 1324
[3] Zhurnal Organicheskoi Khimii, 1992, vol. 28, # 8, p. 1652 - 1660
[4] Journal of Fluorine Chemistry, 1988, vol. 41, p. 247 - 262

4-(DIFLUOROMETHOXY)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(DIFLUOROMETHOXY)BENZALDEHYDE Suppliers

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View Lastest Price from 4-(DIFLUOROMETHOXY)BENZALDEHYDE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(DIFLUOROMETHOXY)BENZALDEHYDE 73960-07-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(DIFLUOROMETHOXY)BENZALDEHYDE 73960-07-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 4-(DIFLUOROMETHOXY)BENZALDEHYDE 73960-07-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-09

73960-07-3, 4-(DIFLUOROMETHOXY)BENZALDEHYDERelated Search:

4-(TRIFLUOROMETHOXY)BENZOYL CHLORIDE 4-(TRIFLUOROMETHOXY)BENZOYL ACETONITRILE 4-(Trifluoromethoxy)benzoic acid 4-(TRIFLUOROMETHOXY)BENZOIC ACID HYDRAZIDE 4-(DIFLUOROMETHOXY)BENZALDEHYDE 4'-(Trifluoromethoxy)acetophenone 4-(DIFLUOROMETHOXY)ACETOPHENONE 4-(TRIFLUOROMETHOXY)BENZAMIDE 4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE 4-(DIFLUOROMETHOXY)PHENACYL BROMIDE METHYL 4-(TRIFLUOROMETHOXY)BENZOATE 4-(Trifluoromethoxy)benzaldehyde 2-(Difluoromethoxy)benzaldehyde, 97+%,2-(Difluoromethoxy)benzaldehyde 97%,2-(DIFLUOROMETHOXY)BENZALDEHYDE 3-(DIFLUOROMETHOXY)BENZALDEHYDE,3-(Difluoromethoxy)benzaldehyde 98%,3-(Difluoromethoxy)benzaldehyde98% (DIFLUOROMETHOXY)BENZENE (4-BROMO-PHENYL)-(4-TRIFLUOROMETHOXY-PHENYL)-METHANONE 4-(1,1,2,2-TETRAFLUOROETHOXY)BENZOIC ACID [3,5-DI(TRIFLUOROMETHYL)PHENYL][4-(TRIFLUOROMETHOXY)PHENYL]METHANONE

TIMTEC-BB SBB003837

VITAS-BB TBB000651

p-(difluoromethoxy)benzaldehyde

BENZALDEHYDE,4-(DIFLUOROMETHOXY)

1-(Difluoromethoxy)-4-formylbenzene

4-(DIFLUOROMETHOXY)BENZALDEHYDE

AKOS B006820

AKOS BBS-00000693

4-(Difluoromethoxy)benzaldehyde 98%

4-(Difluoromethoxy)benzaldehyde98%

4-(Difluoromethoxy)benzaldehyde&gt

4-(Difluoromethoxy)benzaldehyde, 97%,

73960-07-3

Organic Building Blocks

Building Blocks

Carbonyl Compounds

Aldehydes

Fluorine series

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Difluoromethyl

Fluorinated Building Blocks

Organic Building Blocks

Organic Fluorinated Building Blocks

Benzaldehyde

Aldehydes

Carbonyl Compounds