CA-5f

Product Name: CA-5f
CAS No.: 1370032-19-1
Chemical Name: CA-5f
Synonyms: CA-5f;CA-5f, 10 mM in DMSO;CA-5F;CA 5F;CA5F;1370032-19-1;-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-;CA-5f,Apoptosis,inhibit,Autophagy,Inhibitor,CA 5f,CA5f;(3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one;(E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one;4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
CBNumber: CB04808619
Molecular Formula: C24H24N2O3
Formula Weight: 388.46
MOL File: 1370032-19-1.mol

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CA-5f Property

Boiling point:: 639.7±55.0 °C(Predicted)
Density: 1.253±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 77.5 mg/mL (199.51 mM);Water : < 0.1 mg/mL (insoluble)
pka: 16.06±0.30(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb573239
Product name: CA-5f
Purity: >98%
Packaging: 100mg
Price: $838.1
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573182
Product name: CA-5f
Purity: >98%
Packaging: 100mg
Price: $986
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573239
Product name: CA-5f
Purity: >98%
Packaging: 250mg
Price: $1431.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573182
Product name: CA-5f
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573239
Product name: CA-5f
Purity: >98%
Packaging: 1g
Price: $2839
Updated: 2021/12/16

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CA-5f Chemical Properties,Usage,Production

Uses

CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity[1].

Biological Activity

CA-5f is a potent late macroautophagy/autophagy inhibitor, acting by inhibiting autophagosome-lysosome fusion. It increases LC3B-II (a marker that monitors autophagy) and SQSTM1 protein levels and promotes ROS production. Has antitumor activity.

in vivo

CA-5f (40 mg/kg, ip, every 2 days for up to 30 days) is well tolerated, and potently inhibits the growth of tumor in nude mice bearing A549 lung cancer cells.
CA-5f (40 mg/kg, ip) suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.

< td class="col2"> Nude mice bearing A549 lung cancer cells

Animal Model:
Dosage:	40 mg /kg
Administration:	Injected via caudal vein, every 2 days for up to 30 days < /td>
Result:	Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice .

target

Macroautophagy/autophagy

References

[1] Zhang L, et al. Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer. Autophagy. 2019 Mar;15(3):391-406. DOI:10.1080/15548627.2018.1511503

CA-5f Preparation Products And Raw materials

Raw materials

Preparation Products

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CA-5f Suppliers

China 60 United States 6 Global 66

BOC Sciences

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Fan De(Beijing) Biotechnology Co., Ltd.

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1370032-19-1, CA-5fRelated Search:

CA-5f

CA-5F;CA 5F;CA5F;1370032-19-1

4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-

-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-

(E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one

CA-5f,Apoptosis,inhibit,Autophagy,Inhibitor,CA 5f,CA5f

(3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one

CA-5f, 10 mM in DMSO

1370032-19-1

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