CA-5f
- Product Name
- CA-5f
- CAS No.
- 1370032-19-1
- Chemical Name
- CA-5f
- Synonyms
- CA-5f;CA-5f, 10 mM in DMSO;CA-5F;CA 5F;CA5F;1370032-19-1;-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-;CA-5f,Apoptosis,inhibit,Autophagy,Inhibitor,CA 5f,CA5f;(3E,5E)-3-(3,4-dimethoxybenzylidene)-5-[(1H-indol-3-yl)methylene]-1-methylpiperidin-4-one;(E)-3-((1H-Indol-3-yl)methylene)-5-((E)-3,4-dimethoxybenzylidene)-1-methylpiperidin-4-one;4-Piperidinone, 3-[(3,4-dimethoxyphenyl)methylene]-5-(1H-indol-3-ylmethylene)-1-methyl-, (3E,5E)-
- CBNumber
- CB04808619
- Molecular Formula
- C24H24N2O3
- Formula Weight
- 388.46
- MOL File
- 1370032-19-1.mol
CA-5f Property
- Boiling point:
- 639.7±55.0 °C(Predicted)
- Density
- 1.253±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 77.5 mg/mL (199.51 mM);Water : < 0.1 mg/mL (insoluble)
- pka
- 16.06±0.30(Predicted)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- orb573239
- Product name
- CA-5f
- Purity
- >98%
- Packaging
- 100mg
- Price
- $838.1
- Updated
- 2021/12/16
- Product number
- orb573182
- Product name
- CA-5f
- Purity
- >98%
- Packaging
- 100mg
- Price
- $986
- Updated
- 2021/12/16
- Product number
- orb573239
- Product name
- CA-5f
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1431.4
- Updated
- 2021/12/16
- Product number
- orb573182
- Product name
- CA-5f
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1802
- Updated
- 2021/12/16
- Product number
- orb573239
- Product name
- CA-5f
- Purity
- >98%
- Packaging
- 1g
- Price
- $2839
- Updated
- 2021/12/16
CA-5f Chemical Properties,Usage,Production
Biological Activity
CA-5f is a potent late macroautophagy/autophagy inhibitor, acting by inhibiting autophagosome-lysosome fusion. It increases LC3B-II (a marker that monitors autophagy) and SQSTM1 protein levels and promotes ROS production. Has antitumor activity.
in vivo
CA-5f (40 mg/kg, ip, every 2 days for up to 30 days) is well tolerated, and potently inhibits the growth of tumor in nude mice bearing A549 lung cancer cells.
CA-5f (40 mg/kg, ip) suppresses autophagic flux and induces apoptosis in nude mice bearing A549 lung cancer cells.
| Animal Model: | < td class="col2"> Nude mice bearing A549 lung cancer cells|
| Dosage: | 40 mg /kg |
| Administration: | Injected via caudal vein, every 2 days for up to 30 days < /td> |
| Result: | Significantly suppressed tumor volume and weight in mice, increased the number of apoptotic cells in mice . |
target
Macroautophagy/autophagy
CA-5f Preparation Products And Raw materials
Raw materials
Preparation Products
CA-5f Suppliers
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- United States
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