Description References
ChemicalBook > CAS DataBase List > Glycyrrhizic acid

Glycyrrhizic acid

Description References
Product Name
Glycyrrhizic acid
CAS No.
1405-86-3
Chemical Name
Glycyrrhizic acid
Synonyms
GLYCYRRHIZIN;GLYCYRRHIZINATE;18β-Glycyrrhizic acid;Deglycyrrhizinated Licorice;liquorice;Glycyrrhizic acid 1405-86-3;Glycyrrhizine;Glycyrrhizic;glycyrrhizic acid A;glycyron
CBNumber
CB0482721
Molecular Formula
C42H62O16
Formula Weight
822.94
MOL File
1405-86-3.mol
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Glycyrrhizic acid Property

Melting point:
220°C (rough estimate)
Boiling point:
681.01°C (rough estimate)
alpha 
D17 +46.2° (c = 1.5 in alc)
Density 
1.1442 (rough estimate)
refractive index 
61 ° (C=1.5, EtOH)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Ethanol (Slightly), Methanol (Sparingly), Pyridine (Slightly)
form 
Solid
pka
2.76±0.70(Predicted)
color 
White to Light Yellow
Odor
at 100.00 %. mild spicy
Odor Type
spicy
Merck 
14,4505
Stability:
Hygroscopic
InChIKey
BXFBITNYMHAJGT-KYXJNIQISA-N
LogP
4.64
CAS DataBase Reference
1405-86-3
EPA Substance Registry System
Glycyrrhizin (1405-86-3)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
MD2025000
HS Code 
29389090
Hazardous Substances Data
1405-86-3(Hazardous Substances Data)
Toxicity
human,TDLo,oral,5571ug/kg/3D- (5.571mg/kg),KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION,Toxicologist. Vol. 54, Pg. 109, 2000.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1516
Product name
Glycyrrhizic acid
Packaging
200mg
Price
$183
Updated
2024/03/01
Sigma-Aldrich
Product number
1295888
Product name
Glycyrrhizic acid
Packaging
25mg
Price
$1110
Updated
2024/03/01
TCI Chemical
Product number
G0150
Product name
Glycyrrhizin
Purity
>93.0%(T)
Packaging
1g
Price
$48
Updated
2024/03/01
TCI Chemical
Product number
G0150
Product name
Glycyrrhizin
Purity
>93.0%(T)
Packaging
25g
Price
$273
Updated
2024/03/01
Usbiological
Product number
300375
Product name
Glycyrrhizic acid
Packaging
20mg
Price
$276
Updated
2021/12/16
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Glycyrrhizic acid Chemical Properties,Usage,Production

Description

Glycyrrhizic acid is a kind of anti-inflammatory triterpene glycoside extracted from the licorice root. Inside the body, it can be metabolized to glycyrrhetinic acid which inhibits the 11-beta-hydroxysteroid dehydrogenase and some other enzymes related to the corticosteroid metabolism. Glycyrrhizic acid has various pharmacological effects including suppressing hepatic apoptosis and necrosis, anti-inflammatory and immune regulatory actions, antiviral effects, antineoplastic and anticancer effects. It is the active ingredient of licorice root which is commonly used in the treatment of acute and chronic liver injury, viral hepatitis, hepatic steatosis, liver fibrosis, hepatoma, viral myocarditis and other diseases such as psoriasis or prostate cancer. Glycyrrhizic acid is also widely used as a sweetening and flavoring agent in food.

References

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052927/
https://pubchem.ncbi.nlm.nih.gov/compound/Glycyrrhizic_acid#section=Top

Chemical Properties

Glycyrrhizin, also known as glycyrrhizic acid, is a glycoside isolated from the roots of licorice, Glycyrrhiza glabra L. For improved water solubility, an ammoniated salt is commonly used. This can be in the form of either ammonium glycyrrhizinate or monoammonium glycyrrhizinate.

Chemical Properties

White to off-white powder

Uses

glycyrrhizic acid is a hydrolyzed glycyrrhizin. It is credited with antiinflammatory and anti-allergenic properties. Studies comparing glycyrrhizin with hydrocortisone found glycyrrhizin to be somewhat milder but longer lasting in effectiveness. once the application of hydrocortisone is suspended, the symptoms return. This does not appear to be the case with glycyrrhizin. It does not have side effects and is chemically stable so it can be safely used on a continuing basis.

Uses

11beta-hydroxysteroid dehydrogenase inhibitor, antiinflammatory, expectorant, antihaemorrhagic, anti-HIV

Uses

Glycyrrhizic acid is a triterpene saponin used in the traditional Chinese medicinal preparation for its anti-inflammatory , antiulcerous and antiallergic effects.

Uses

Glycyrrhizin is a flavorant and foaming agent derived from the separation of flavonoids found in the whole licorice extract from the licorice root glycyrrhiza glabra. It is 50–100 times as sweet as sugar, is soluble in water, and has a licorice taste. It has good heat stability but prolonged heating can result in some degradation. It is stable within ph 4–9; below ph 4 there could be precipitation. It has foaming and emulsifying properties in water, being used in cocktail mixes and soft drinks. It is used as a flavorant in bacon and imitation whipped products. It is synergistic with sugar, the sweetness being amplified to 100 times that of cane sugar alone. It is used as a sweetener in sugar-free chewing gum and low-fat sugar-free frozen desserts. It is also termed ammoniated glycyrrhizin. Monoammonium glycyrrhizinate is obtained by additional refinement.

Definition

ChEBI: A triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence and changes in the metabolism of phosphorus, When heated to decomposition it emits acrid smoke and irritating fumes.

Glycyrrhizic acid Preparation Products And Raw materials

Raw materials

VEGETABLEPROTEIN DGL IRISH MOSS

Preparation Products

Glycyrrhizic acid ammonium salt DISODIUM GLYCYRRHIZATE monopotassium and tripotassium glycyrrhi-mate LICORICE EXTRACT licorice root antioxidant Glucosyl licorice Monoglucuronyl glycyrrehetic acid 18β-Glycyrrhetinic Acid
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View Lastest Price from Glycyrrhizic acid manufacturers

Sinoway Industrial co., ltd.
Product
Glycyrrhizic Acid 1405-86-3
Price
US $0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
0.99
Supply Ability
20 tons
Release date
2022-12-16
Hebei Kingfiner Technology Development Co.Ltd
Product
Glycyrrhizic acid 1405-86-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500000kg
Release date
2024-06-11
Hebei Guanlang Biotechnology Co., Ltd.
Product
Glycyrrhizic acid 1405-86-3
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-02-20

1405-86-3, Glycyrrhizic acidRelated Search:

Ethyl 2-(Chlorosulfonyl)acetate Citric acid Diethylstilbestrol Stearic acid Folic acid α-Lipoic Acid Hyaluronic acid Ascoric Acid Diammonium glycyrrhizinate Glycyrrhizic acid 2NH4 GLYCYRRHIZIC ACID TRISODIUM SALT HYDRATE,GLYCYRRHIZIC ACID TRISODIUM SALT Monopatassium glycyrrhizinate Ammonium citrate dibasic Ammonium Glycyrrhizinate 18β-Glycyrrhizic acid dipotassium salt,GLYCYRRHIZIC ACID DIPOTASSIUM SALT HYDRATE,GLYCYRRHIZIC ACID DIPOTASSIUM SALT 4,4'-Diamino-2,2'-stilbenedisulfonic acid GLYCYRRHIZIC ACID, NH4+,GLYCYRRHIZIC ACID, NH4,GLYCYRRHIZIC ACID AMMONIUM,GLYCYRRHIZIC ACID AMMONIUM SALT,GLYCYRRHIZIC ACID MONOAMMONIUM SALT Stearyl glycyrrhetinate

  • Glycyrrhizic acid 1405-86-3
  • Glycyrrhizic acid,from licorice
  • GLYCYRRHIZIN
  • GLYCYRRHIZINATE
  • GLYCYRRHYCIC ACID
  • GLYCYRRHIZIC ACID
  • GLYCYRRHETINIC ACID GLYCOSIDE
  • 3-o-(2-o-beta-d-glucopyranuronosyl-alpha-d-glucopyranuronosyl)-18beta-g lycyrrhetinic acid
  • Glycyrrhisinic acid power 21% W/W
  • Glycyrrhizinate acid 15-18% (R-19)
  • Glycyrrhizin std.
  • Glycyrrhizic
  • .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-
  • Potassium Glycyrrhetate
  • 18β-Glycyrrhizic acid
  • Glycyrrhizic acid (8CI)
  • NSC 167409
  • NSC 234419
  • Potenlini
  • α-D-Glucopyranosiduronic acid, (3β,20β)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-
  • glucopyranuronosyl-.alpha.-D-Glucopyranosiduronic acid
  • DerMacrin
  • Glycyrrhitin
  • Of glycyrrhizin
  • Radix Glycyrrhizae
  • Glycyrrhizin (Glycyrrhizic Acid)
  • Glycyrrhizic acid 3-O-(2-O-beta-D-Glucopyranuronosyl-alpha-D-glucopyranuronosyl)-18beta-g lycyrrhetinic acid
  • 3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid
  • glycyrrhizic acid A
  • Glycyrrhizic acid, >=98%
  • (3β,18α)-30-hydroxy-11,30-dioxoolean-12-en-3-yl 2-O-β-D-glucopyranuronosyl-β-D-glucopyranosiduronic acid
  • Glycyrrhizic Acid 〔Glycyrrhizin〕
  • Glycyrrhizic acid, 98%, from Glycyrrhiza uralensis Fisch.
  • Gross Glycyrrhizic Acid
  • Glycyrrhizinic
  • 18-beta-glycyrrhizicacid
  • 20beta-carboxy-11-oxo-30-norolean-12-en-3beta-yl-2-o-beta-d-glucopyranuronosyl
  • -alpha-d-glucopyranosiduronicacid
  • alpha-d-glucopyranosiduronicacid,(3beta,20beta)-20-carboxy-11-oxo-30-norol
  • alpha-d-glucopyranosiduronicacid,(3beta,20beta)-20-carboxy-11-oxo-30-norolean
  • beta-glycyrrhizin
  • ean-12-en-3-yl2-o-beta-d-glucopyranuronosyl-
  • glycyron
  • Glycyrrhizine
  • glycyrrhizinicacid
  • liquorice
  • carboxy-11-oxo-30- norolean-12-en-3-yl 2-O-β-D-
  • glucopyranuronosyl-
  • β-D-Glucopyranosiduronic acid, (3β,20β)-20-
  • (3beta,20beta)-20-Carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-1- 7-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid
  • 30-Noroleanane, a-D-glucopyranosiduronic acid deriv.
  • a-D-Glucopyranosiduronic acid, (3b,20b)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-b-D-glucopyranuronosyl-
  • (20S)-3β-[(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)oxy]-11-oxoolean-12-en-30-oic acid
  • GLYCYRRHIZIC ACID(P)(CALL)
  • Glycyrrhizic Acid (25 mg)
  • GLYCYRRHIZIC ACID(P)
  • 5-[(6-carboxy-3,4,5-trihydroxyoxan-2-yl)oxy]-6-[(11-carboxy-4,4,6a,6b,8a,11,14b-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicen-3-yl)oxy]-3,4-dihydroxyoxane-2-carboxylic acid
  • (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl2-O-.beta.-D-glucopyranuronosyl-.alpha.-D-Glucopyranosiduronicacid